Volume 519 Number 7541

Editorials

エボラ出血熱の流行で疲弊した西アフリカ地域では、妊娠した女性への支援が必要だ。

Fatal fallout p.5

The Ebola epidemic has had a dire effect on the health prospects of pregnant women.

doi: 10.1038/519005b

気候変動懐疑論者であるWillie Soonの資金的背景の調査は、政治的動機によるものであり、学問の自由を脅かす恐れがある。

Gone fishing p.5

An investigation into the funding sources of climate scientists who have testified to the US Congress makes demands that have the potential to infringe on academic freedom.

doi: 10.1038/519005a

ドレスの色が「青かどうか」をめぐるネット上での論争で、視覚認識の科学が注目を浴びている。

Hues and cry p.6

A blue dress divided the Internet — and put the science of visual perception in the spotlight.

doi: 10.1038/519006a

News

アフリカで、エボラ出血熱流行が人々の心の健康に大きな傷を。

Ebola’s mental-health wounds linger in Africa p.13

Health-care workers struggle to help people who have been traumatized by the epidemic.

doi: 10.1038/519013a

米国防高等研究計画局(DARPA)の緊急救援作業ロボットコンペで、25台が決勝に。

Robo-rescuers battle it out in disaster challenge p.14

Nimble bots to go head-to-head for $2-million DARPA prize.

doi: 10.1038/519014a

IPCC(気候変動に関する政府間パネル)が、新議長選出を前に、その評価プロセスなどについて細部の変更を。

UN climate panel charts next steps p.15

IPCC prepares for new leadership and plans another assessment of climate science.

doi: 10.1038/519015a

国連が、噴火記録や周辺人口などから世界の火山の災害リスクを評価し、公表を。

World's deadliest volcanoes identified p.16

Indonesia's population most at risk from eruptions.

doi: 10.1038/519016a

がん治療ワクチンとして米国で初めて認可されたProvengeが、開発会社の破綻を乗り切り、存続へ。

Therapeutic cancer vaccine survives biotech bust p.17

Pharmaceutical company rescues landmark prostate-cancer treatment, Provenge.

doi: 10.1038/519017a

干ばつに悩まされる米南西部に、貯水池からの蒸発を薄層で防ぐアイデアが。

Slick idea proposed to stretch water supplies p.18

In drought-ridden US, water managers consider using a coating one molecule thick to reduce evaporation from reservoirs.

doi: 10.1038/519018a

News Features

発展途上国:少数派の少数派

Developing world: The minority minority p.20

女性研究者自体が少数派である途上国の科学界で、世界的に見ても女性の少ない物理科学分野で活躍している3人の研究者を紹介する。

doi: 10.1038/519020a

公衆衛生:エボラの消えない傷痕

Maternal health: Ebola’s lasting legacy p.24

エボラ出血熱の大流行がもたらした最も深刻な被害の1つは、母体の健康への悪影響かもしれない。

doi: 10.1038/519024a

News & Views

HIV:自身の受容体にくぎ付けにされる

HIV: Tied down by its own receptor p.36

HIVウイルスのエンベロープに結合する人工タンパク質が、サルやヒトでエイズを引き起こすウイルスへの感染からサルを守ることが分かった。遺伝子治療のこのような手法は、作製が困難なHIVワクチンの代わりとなるかもしれない。

doi: 10.1038/nature14205

材料科学:燃料の要らないナノスケール運動

Materials science: Nanoscale locomotion without fuel p.37

グラフェンからなるナノ構造体をその下にある基板の固さを調節して一方向に動かすことができる仕組みが、コンピューターシミュレーションにより明らかにされた。

doi: 10.1038/519037a

神経科学:「腹ぺこ!」の細胞基盤

Neuroscience: A cellular basis for the munchies p.38

マリファナが、「munchies」と言われる、我慢しにくい空腹感を引き起こす仕組みはどのようなものなのだろうか。逆説的な答えだが、これには、食欲を抑制することでよく知られている脳回路の異例な形の活性化が関わっているらしい。

doi: 10.1038/nature14206

分子生物学:生物のドメインを超えて存在するシグナル

Molecular biology: Signals across domains of life p.40

メッセンジャーRNAに含まれ、タンパク質合成を開始させるシグナル配列は生物のドメイン間で互換性があるとは考えられていなかった。節足動物に感染するウイルスから送られるシグナルが細菌で機能することが分かり、こうした考え方に疑問が投げ掛けられた。

doi: 10.1038/nature14202

材料科学:圧力を使うゲーティング機構

Materials science: Gating mechanism under pressure p.41

膜にあって液体で満たされている小孔を可逆的に開閉できるように設計しておくと、決まった圧力をかければ特定の液体だけが通過できるようになる。これを使うと、混ざり合わない液体の混合物を、ゲート開閉によって調節しながら分離できるようになる。

doi: 10.1038/519041a

触媒:スイッチ1つで2通りの機能が切り替えられる触媒

Catalysis: Dual catalysis at the flick of a switch p.42

光活性化触媒ともう1種類の触媒の2つを組み合わせて使うことで、新しい化学反応が容易に行えるようになり、複雑な構造を持つ有機分子の合成に新しい道が開けた。

doi: 10.1038/519042a

Articles

神経科学:視床下部POMCニューロンがカンナビノイド誘導性摂食を促進する

Hypothalamic POMC neurons promote cannabinoid-induced feeding p.45

Cannabinoid-induced feeding signals are shown to enhance pro-opiomelanocortin (POMC) neuronal activity in mice, causing an enhancement of β-endorphin release, which is crucial in causing this cannabinoid-induced response; these results uncover an overlooked role of hypothalamic POMC neurons in the promotion of feeding by cannabinoids.

doi: 10.1038/nature14260

神経科学:運動の計画と運動に関わる運動皮質回路

A motor cortex circuit for motor planning and movement p.51

During movement preparation, motor cortical neuronal subpopulations that project to downstream motor areas are more selective for the direction of upcoming movement than those that project to other cortical targets, especially immediately before movement, emphasizing the need to interpret complex neuronal responses measured during behaviour in the context of hierarchically organized cortical circuits.

doi: 10.1038/nature14178

医学:gp130–Src–YAPモジュールは炎症と上皮再生を結び付ける

A gp130–Src–YAP module links inflammation to epithelial regeneration p.57

This study demonstrates the activation of a STAT3-independent healing pathway in response to mucosal injury which involves the co-receptor for IL-6 cytokines gp130 and downstream effectors Src, Yes, YAP and Notch.

doi: 10.1038/nature14228

Letters

宇宙物理学:惑星状星雲Henize 2-428の、双縮退しスーパー・チャンドラセカール状態を示すコア

The double-degenerate, super-Chandrasekhar nucleus of the planetary nebula Henize 2-428 p.63

The probable evolution of the planetary nebula Henize 2-428 is examined, from a close binary system in which both stars ejected their envelopes to the white dwarf stage with a short orbital period and combined mass above the Chandrasekhar limit, suggesting that the system should merge in about 700 million years and trigger a type Ia supernova.

doi: 10.1038/nature14124

量子物理学:超伝導量子回路における繰り返しエラー検出による状態保存

State preservation by repetitive error detection in a superconducting quantum circuit p.66

A quantum error correction scheme is demonstrated in a system of superconducting qubits, and repeated quantum non-demolition measurements are used to track errors and reduce the failure rate; increasing the system size from five to nine qubits improves the failure rate further.

doi: 10.1038/nature14270

材料科学:調節可能な多相選択性と防汚挙動を示す液体ベースのゲーティング機構

Liquid-based gating mechanism with tunable multiphase selectivity and antifouling behaviour p.70

A rapid, reversible, non-fouling gating mechanism is created by infusing a porous membrane with a capillary-stabilized liquid that reconfigures under pressure to form a liquid-lined pathway, enabling selective multiphase transport with rationally tunable differential response profiles for a variety of liquids and gases.

doi: 10.1038/nature14253

有機化学:有機触媒反応および光酸化還元触媒反応によるアリルsp3 C–H結合の直接アリール化

The direct arylation of allylic sp3 C–H bonds via organic and photoredox catalysis p.74

Photoredox and organic catalysis are combined to achieve broadly effective direct arylation of allylic carbon–hydrogen bonds under mild conditions; this carbon–carbon bond forming reaction readily accommodates a wide range of alkene and electron-deficient arene coupling partners.

doi: 10.1038/nature14255

生態学:干ばつがアマゾン川流域の森林の炭素動態と炭素フラックスに与える影響

Drought impact on forest carbon dynamics and fluxes in Amazonia p.78

Severe drought in a tropical forest ecosystem suppresses photosynthetic carbon uptake and plant maintenance respiration, but growth is maintained, suggesting that, overall, less carbon is available for tree tissue maintenance and defence, which may cause the subsequent observed increase in tree mortality.

doi: 10.1038/nature14213

古生物学:復元されたホモ・ハビリスのタイプ標本OH 7は初期ヒト属でかなり早い段階に種多様性が生じたことを示唆する

Reconstructed Homo habilis type OH 7 suggests deep-rooted species diversity in early Homo p.83

Virtually reconstructing the jaw of OH 7 reveals a remarkably primitive shape, suggesting that the Homo habilis lineage originated before 2.3 million years ago; marking deep-rooted species diversity in the genus Homo.

doi: 10.1038/nature14224

免疫学:AAVを使って発現させたeCD4-Igは複数回のSHIV攻撃投与に対して持続性のある防御を示す

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges p.87

The new entry inhibitor eCD4-Ig, consisting of the immunoadhesin form of CD4 (CD4-Ig) fused to a small CCR5-mimetic sulfopeptide, avidly binds two highly conserved sites of the HIV-1 Env protein; the inhibitor has high potency and breadth and can neutralize 100% of a diverse panel of neutralization-resistant HIV-1 viruses, and when delivered to macaques using an adeno-associated virus vector, it can provide effective long-term protection from multiple challenges with simian/human immunodeficiency virus.

doi: 10.1038/nature14264

炎症:食物中の乳化剤がマウスの腸内微生物相に影響を与え、大腸炎とメタボリックシンドロームを助長する

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome p.92

Emulsifying agents, which are common food additives in the human diet, induce low-grade inflammation and obesity/metabolic syndrome in mice, suggesting that further investigation into the potential impact of dietary emulsifiers on the gut microbiota and human heath are warranted.

doi: 10.1038/nature14232

老化:耐性幼虫形成とは独立のインスリン/IGF-1シグナル伝達がコラーゲンリモデリングを長寿に関連付ける

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity p.97

In Caenorhabditis elegant, reduced insulin/IGF-1 signalling can promote longevity through a program that is genetically distinct from the dauer developmental pathway, and requires SKN-1-dependent collagen remodelling that is a broadly essential feature of longevity assurance pathways.

doi: 10.1038/nature14021

がん:アキシチニブは固有の結合コンホメーションによりBCR–ABL1(T315I)を効果的に抑制する

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation p.102

A large ex vivo screen of approved and investigational anti-cancer drugs in primary cells derived from CML and ALL patients identifies axitinib, a VEGFR inhibitor approved for the treatment of kidney cancer, as a potent inhibitor of BCR–ABL1(T315I) with unique binding interactions that overcome the gatekeeper resistance mutation, highlighting the potential of repurposing existing drugs for additional cancer types.

doi: 10.1038/nature14119

生化学:天然変性タンパク質の1つはリン酸化によって折りたたまれて調節スイッチとなる

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch p.106

The structural polymorphism of intrinsically disordered protein 4E-BP2 allows it to regulate translation initiation through post-translational modification-mediated folding, exemplifying a new and potentially general mechanism of biological regulation mediated by intrinsically disordered proteins.

doi: 10.1038/nature13999

分子生物学:構造化された真核生物のIRES RNAによる細菌での翻訳開始

Initiation of translation in bacteria by a structured eukaryotic IRES RNA p.110

A eukaryotic viral internal ribosome entry site (IRES) element is described that binds both bacterial and eukaryotic ribosomes and initiates translation in both, demonstrating that RNA structure-based initiation can occur in both these domains of life, although in bacteria the element uses a mechanism that differs from that in eukaryotes.

doi: 10.1038/nature14219

構造生物学:Fアクチン–トロポミオシン複合体の構造

Structure of the F-actin––tropomyosin complex p.114

Electron cryomicroscopy reveals the three-dimensional structure of F-actin at a resolution of 3.7 Å in complex with tropomyosin at a resolution of 6.5 Å; the stabilizing interactions and the effects of disease-causing mutants are also investigated.

doi: 10.1038/nature14033

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