Premature burial, show business and the Nobel prize p.5

Awards week shows the value of a strong brand identity.

doi: 10.1038/538005b


Oppose the UK Higher Education and Research Bill p.5

The proposed law would demolish agreements that protect British universities from political interference.

doi: 10.1038/538005a


The limits to human lifespan must be respected p.6

Lengthening our lives will come at a cost.

doi: 10.1038/538006a



Mission accomplished: Rosetta crashes into comet p.13

Craft sends back wealth of images in 19-kilometre descent.

doi: 10.1038/nature.2016.20705


US left with just one working fusion reactor — for now p.14

Design flaw may have doomed machine at Princeton Plasma Physics Lab.

doi: 10.1038/nature.2016.20710


Syrian seed bank gets new home away from war p.16

Ancient genes will soon be available to researchers again, but the move poses its own challenges.

doi: 10.1038/538016a


UK bioethicists eye designer babies and CRISPR cows p.17

Panel will focus on the implications of gene editing in human reproduction and livestock.

doi: 10.1038/nature.2016.20713


Medicine Nobel for research on how cells 'eat themselves' p.18

Japanese biologist Yoshinori Ohsumi recognized for work on autophagy.

doi: 10.1038/nature.2016.20721


Physics of 2D exotic matter wins Nobel p.18

British-born theorists recognized for work on topological phases.

doi: 10.1038/nature.2016.20722

News Features


Can we open the black box of AI? p.20


doi: 10.1038/538020a


Warning to forest destroyers: this scientist will catch you p.24

米国メリーランド大学の地理学者Matthew Hansenの研究チームは、衛星データを基に、森林破壊が進んでいる場所をリアルタイムで検出できるマップを作製している。

doi: 10.1038/538024a

News & Views


Catalysis: Cobalt gets in shape p.44


doi: 10.1038/538044a


Cancer: Acidic shield puts a chink in p53's armour p.45


doi: 10.1038/nature19469


Biogeochemistry: Rebalancing the global methane budget p.46


doi: 10.1038/538046a


Particle physics: Search for neutrinoless double-β decay p.48


doi: 10.1038/nature19473


Human migration: Climate and the peopling of the world p.49


doi: 10.1038/nature19471



Circuit-based interrogation of sleep control p.51

Weber and Dan review our understanding of the neural circuits controlling sleep, focusing on the advances in measurement and manipulation of neuronal activity and circuit tracing from genetically defined cell types.

doi: 10.1038/nature19773



Structural insight into the role of the Ton complex in energy transduction p.60

Structural studies shed light on the function and stoichiometry of the Ton complex, which harnesses the proton motive force across the bacterial inner membrane to transduce energy to the outer membrane.

doi: 10.1038/nature19757


X-ray structures define human P2X3 receptor gating cycle and antagonist action p.66

Structures of the human P2X3 receptor in its open, closed, desensitized and antagonist-bound states show the receptor’s gating mechanism and the basis of antagonist binding.

doi: 10.1038/nature19367



High-molecular-weight organic matter in the particles of comet 67P/Churyumov–Gerasimenko p.72

The COSIMA mass spectrometer on the Rosetta spacecraft has analysed the solid organic matter found in dust particles emitted by comet 67P/Churyumov–Gerasimenko; this matter is similar to the insoluble organic matter extracted from carbonaceous chondrites such as the Murchison meteorite, but is perhaps more primitive.

doi: 10.1038/nature19320


Nodal-chain metals p.75

A hitherto unrecognized type of fermionic excitation in metals is described, which forms a chain of connected loops in momentum space (a nodal chain) along which conduction and valence bands touch.

doi: 10.1038/nature19099


Surface patterning of nanoparticles with polymer patches p.79

Surface patterning of nanoparticles with polymer patches is achieved in a poor solvent for the polymer by controlling the ratio between the sizes of polymer molecules and nanoparticles.

doi: 10.1038/nature19089


Cobalt carbide nanoprisms for direct production of lower olefins from syngas p.84

Lower olefins are hydrocarbons that are widely used in the chemical industry, and can be generated from syngas by the ‘Fischer–Tropsch to olefins’ process; here, a new catalyst is described that can generate lower olefins from syngas with high selectivity, with little formation of undesirable methane.

doi: 10.1038/nature19786


Upward revision of global fossil fuel methane emissions based on isotope database p.88

Revisions in isotopic source signatures reveal that global total fossil fuel methane emissions from industry plus natural geological seepage are much larger than thought.

doi: 10.1038/nature19797


Late Pleistocene climate drivers of early human migration p.92

The dispersal of Homo sapiens across the Arabian Peninsula and the Levant during the last glacial period was not a single event, but occurred in four astronomically-paced migration waves.

doi: 10.1038/nature19365


A cross-modal genetic framework for the development and plasticity of sensory pathways p.96

In the neocortex, sensory information flows into areas specific for a particular modality through parallel thalamocortical circuits, consisting of first order and higher order nuclei connecting to primary and secondary cortical areas, respectively; here, the authors identify common developmental genetic programs that organize these conserved features in parallel sensory pathways.

doi: 10.1038/nature19770


Autocrine BDNF–TrkB signalling within a single dendritic spine p.99

Live fluorescent imaging of murine hippocampal slices shows that NMDAR-dependent glutamate signalling leads to postsynaptic BDNF release, with associated signalling of its receptor, TrkB, on the same dendritic spine, suggesting autocrine BDNF signalling.

doi: 10.1038/nature19766

神経科学:Rho GTPアーゼによる補完はホモシナプスおよびヘテロシナプスのBDNF依存的な可塑性の基礎である

Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity p.104

The three small GTPases Rac1, RhoA and Cdc42 are differentially involved in structural long-term potentiation of rodent dendritic spines, simultaneously ensuring signal specificity and also priming the system for plasticity.

doi: 10.1038/nature19784


The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila p.109

Attenuating the lipolysis pathway in Drosophila melanogaster by modulation of the COP1–Arf1 signalling complex induced necrosis in stem cells and led to their engulfment by differentiated cells.

doi: 10.1038/nature19788


XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer p.114

A multi-genomic approach identifies the addiction of KRAS-mutant lung cancer cells to XPO1-dependent nuclear export, offering a new therapeutic opportunity.

doi: 10.1038/nature19771


Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode p.118

The acidic domain of SET binds and represses unacetylated p53, but this interaction is prevented by cellular-stress-induced p53 CTD acetylation.

doi: 10.1038/nature19759


Accessory subunits are integral for assembly and function of human mitochondrial complex I p.123

Gene-editing technology and large-scale proteomics are used to provide insights into the modular assembly of the human mitochondrial respiratory chain complex I, as well as identifying new assembly factors.

doi: 10.1038/nature19754

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