Ocean circulation is changing, and we need to know why p.149

Long-term monitoring is essential for working out how alterations in the Atlantic Ocean current system will affect the planet.

doi: 10.1038/d41586-018-04322-x


How gravitational waves might help fundamental cosmology p.149

New observations could help us understand discrepancies in measurements of the expansion of the Universe.

doi: 10.1038/d41586-018-04321-y

ネイチャー・リサーチとザ エスティ ローダー カンパニーズは、女性の科学分野における活躍の機会を増やし讃えるべく、2つの賞を新設する。

New awards aim to celebrate women in science p.150

Prizes will reward outstanding scientific discovery and exceptional efforts to engage girls and young women in science.

doi: 10.1038/d41586-018-04323-w



Beijing launches pioneering brain-science centre p.157

China’s much-anticipated brain initiative finally starts to take shape.

doi: 10.1038/d41586-018-04122-3


NASA’s next exoplanet hunter will seek worlds close to home p.158

The Transiting Exoplanet Survey Satellite is designed to spot planets orbiting nearby bright stars.

doi: 10.1038/d41586-018-03354-7


Science’s vast gender pay gap revealed in UK wage data p.160

Pay disparities at science employers outpace national average for all firms.

doi: 10.1038/d41586-018-04309-8


Plan to dismantle Puerto Rico’s statistics agency gets green light p.161

The reorganization could jeopardize access to reliable, independent data about the island, critics say.

doi: 10.1038/d41586-018-04120-5


Cutting-edge cancer drug hobbled by diagnostic test confusion p.161

Physicians struggle to identify which patients are likely to respond to a recently approved therapy.

doi: 10.1038/d41586-018-03862-6

News Features


Astrophysics: How gravitational waves could solve some of the Universe’s deepest mysteries p.164


doi: 10.1038/d41586-018-04157-6

News & Views


The certainty of randomness p.176


doi: 10.1038/d41586-018-04105-4


Mirrors made of a single atomic layer p.177


doi: 10.1038/d41586-018-04089-1


Peptide signal alerts plants to drought p.178


doi: 10.1038/d41586-018-03872-4


North Atlantic circulation slows down p.180


doi: 10.1038/d41586-018-04086-4


The telomerase enzyme and liver renewal p.181


doi: 10.1038/d41586-018-02684-w


Backbone of RNA viruses uncovered p.182


doi: 10.1038/d41586-018-03923-w



Reversible Mn2+/Mn4+ double redox in lithium-excess cathode materials p.185

Lithium-rich cathode materials in which manganese undergoes double redox could point the way for lithium-ion batteries to meet the capacity and energy density needs of portable electronics and electric vehicles.

doi: 10.1038/s41586-018-0015-4


Observed fingerprint of a weakening Atlantic Ocean overturning circulation p.191

A characteristic ‘fingerprint’ of sea-surface temperatures suggests that the Atlantic overturning circulation has slowed substantially since the mid-twentieth century, as predicted by climate models in response to increasing carbon dioxide emissions.

doi: 10.1038/s41586-018-0006-5


The evolutionary history of vertebrate RNA viruses p.197

Around 200 new vertebrate-specific viruses are discovered, and every vertebrate-specific viral family known to infect mammals and birds is also present in amphibians, reptiles or fish, suggesting that evolution of vertebrate viruses mirrors that of vertebrate hosts.

doi: 10.1038/s41586-018-0012-7

構造生物学:Blastochloris viridis LH1–RC複合体の分解能2.9 Åでのクライオ電子顕微鏡構造

Cryo-EM structure of the Blastochloris viridis LH1–RC complex at 2.9 Å p.203

A cryo-electron microscopy structure of the light-harvesting–reaction centre (LH1–RC) complex of the photosynthetic bacterium Blastochloris viridis suggests factors that underlie the large redshift in the absorption spectrum of bacteriochlorophyll in the complex and that promote quinone–quinol translocation across the LH1 ring.

doi: 10.1038/s41586-018-0014-5

構造生物学:光合成LH1–RC超複合体の分解能1.9 Åでの構造

Structure of photosynthetic LH1–RC supercomplex at 1.9 Å resolution p.209

The structure of the Thermochromatium tepidum calcium-ion-bound light-harvesting–reaction centre (LH1–RC) supercomplex, which performs the primary reactions of photosynthesis in purple photosynthetic bacteria, is resolved to the atomic level.

doi: 10.1038/s41586-018-0002-9


Crystal structures of the gastric proton pump p.214

Crystal structures of the gastric proton pump in complex with two inhibitory drugs reveal the mechanism that generates the steep acidic gradient across the membranes of parietal cells.

doi: 10.1038/s41586-018-0003-8



Alteration of the magnetosphere of the Vela pulsar during a glitch p.219

Single-pulse radio observations of a glitch in the Vela pulsar show sudden changes in the pulse shape coincident with the glitch, indicating that the glitch could affect the pulsar’s magnetosphere.

doi: 10.1038/s41586-018-0001-x


Experimentally generated randomness certified by the impossibility of superluminal signals p.223

1,024 random bits that are uniformly distributed to within 10−12 and unpredictable assuming the impossibility of superluminal communication are generated and certified using a loophole-free Bell test.

doi: 10.1038/s41586-018-0019-0


Anomalously weak Labrador Sea convection and Atlantic overturning during the past 150 years p.227

Palaeoclimate records show that the Atlantic meridional overturning circulation weakened substantially at the end of the Little Ice Age, probably in response to enhanced freshwater fluxes from the Arctic and Nordic seas.

doi: 10.1038/s41586-018-0007-4


Accelerated increase in plant species richness on mountain summits is linked to warming p.231

Analysis of changes in plant species richness on mountain summits over the past 145 years suggests that increased climatic warming has led to an acceleration in species richness increase.

doi: 10.1038/s41586-018-0005-6


A small peptide modulates stomatal control via abscisic acid in long-distance signalling p.235

In an Arabidopsis model, the CLE25 peptide acts as a root-to-shoot signalling molecule that modulates abscisic acid expression to close stomata and enhance resistance to dehydration.

doi: 10.1038/s41586-018-0009-2


Advanced maturation of human cardiac tissue grown from pluripotent stem cells p.239

A tissue culture system that provides an increasing intensity of electromechanical stimulation over time enables an in vitro model of cardiac tissue derived from human induced pluripotent stem cells to develop many of the characteristics of adult cardiac tissue.

doi: 10.1038/s41586-018-0016-3


Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury p.244

A population of hepatocytes expressing high levels of telomerase are distributed throughout the liver and regenerate the liver during homeostasis and after injury.

doi: 10.1038/s41586-018-0004-7


Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer p.249

The glycolytic enzyme PFKFB4 directly phosphorylates and regulates binding of the coactivator SRC-3 to ATF4 and thereby increases the transcriptional activity of this complex, leading to increased expression of metabolic genes, and enhancing tumour growth and metastasis.

doi: 10.1038/s41586-018-0018-1


Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin p.255

Analysis of viral samples from deceased piglets shows that a bat coronavirus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbreaks of disease.

doi: 10.1038/s41586-018-0010-9

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