Volume 536 Number 7615



Physicists need to make the case for high-energy experiments p.125

The disappearance of a tantalizing LHC signal is disappointing for those who want to build the next big accelerator.

doi: 10.1038/536125b


A safe place for nuclear energy? p.125

Rewarding existing nuclear power plants for the value of their low-carbon power makes sense, but the nuclear industry has a lot of work to do if it is survive and thrive in the twenty-first century.

doi: 10.1038/536125a



Hopes for revolutionary new LHC particle dashed p.133

But the hunt continues for elementary particles beyond the standard model of physics.

doi: 10.1038/nature.2016.20376


Glider aims to break world record — and boost climate science p.134

Perlan mission will surf stratospheric waves and conduct atmospheric research.

doi: 10.1038/536134a


US agency to lift ban on funding human–animal hybrids p.135

Researchers in the United States will soon be able to resume creating chimaera-based projects.

doi: 10.1038/nature.2016.20379


Beyond CRISPR: A guide to the many other ways to edit a genome p.136

The popular technique has limitations that have sparked searches for alternatives.

doi: 10.1038/536136b


Replications, ridicule and a recluse: the controversy over NgAgo gene-editing intensifies p.136

As failures to replicate results using the CRISPR alternative stack up, a quiet scientist stands by his claims.

doi: 10.1038/536136a


Plant and animal DNA suggests first Americans took the coastal route p.138

Life came to ice-free Canadian corridor too late to sustain migrations of Clovis and pre-Clovis people.

doi: 10.1038/536138a

News Features


The bandwidth bottleneck that is throttling the Internet p.139


doi: 10.1038/536139a

News & Views


Energy science: Fast track for silver p.150


doi: 10.1038/536150a


Neuroscience: Nanocolumns at the heart of the synapse p.151


doi: 10.1038/nature18917


Systems neuroscience: A modern map of the human cerebral cortex p.152


doi: 10.1038/nature18914


Cancer: Endothelial-cell killing promotes metastasis p.154


doi: 10.1038/nature19465


Cell biology: The TORC1 pathway to protein destruction p.155


doi: 10.1038/nature18919


Cancer: Fat and the fate of pancreatic tumours p.157


doi: 10.1038/nature19419



Synergistic, ultrafast mass storage and removal in artificial mixed conductors p.159

An artificial composite of the super-ionic conductor RbAg4I5 and the electronic conductor graphite exhibits extremely fast diffusion of silver ions at the interface between the two materials, generating both silver-excess and silver-deficient sites.

doi: 10.1038/nature19078


Tempo and mode of genome evolution in a 50,000-generation experiment p.165

Whole-genome sequencing of 264 clones sampled from 12 Escherichia coli populations evolved over 50,000 generations under identical culture conditions is used to characterize the patterns and dynamics of genome evolution over time.

doi: 10.1038/nature18959


A multi-modal parcellation of human cerebral cortex p.171

A detailed parcellation (map) of the human cerebral cortex has been obtained by integrating multi-modal imaging data, including functional magnetic resonance imaging (fMRI), and the resulting freely available resources will enable detailed comparative studies of the human brain in health, ageing and disease.

doi: 10.1038/nature18933


SAR11 bacteria linked to ocean anoxia and nitrogen loss p.179

Bacteria of the SAR11 clade constitute up to one half of all marine microbes and are thought to require oxygen for growth; here, a subgroup of SAR11 bacteria are shown to thrive in ocean oxygen minimum zones and to encode abundant respiratory nitrate reductases.

doi: 10.1038/nature19068


An evolutionarily conserved pathway controls proteasome homeostasis p.184

Proteasome abundance is crucial for cell survival, but how cells maintain adequate amounts of proteasome is unclear; an analysis in yeast identifies TORC1 and Mpk1 as central components of a pathway regulating proteasome homeostasis through the coordinated regulation of regulatory particle assembly chaperones and proteasome subunits—this pathway is evolutionarily conserved with mTOR and ERK5 regulating proteasome abundance in mammals.

doi: 10.1038/nature18943



Heating of Jupiter’s upper atmosphere above the Great Red Spot p.190

The upper atmosphere above Jupiter’s Great Red Spot—the largest storm in the Solar System—is hundreds of degrees hotter than anywhere else on the planet; the heating must come from below, suggesting coupling between Jupiter’s lower and upper atmospheres, probably the result of upwardly propagating acoustic or gravity waves.

doi: 10.1038/nature18940


A photon–photon quantum gate based on a single atom in an optical resonator p.193

To enable two photons to interact, a single atom in an optical resonator is used to build a universal photon–photon quantum gate; this could lead to applications in long-distance quantum communication and scalable quantum computing that require the processing of optical quantum information.

doi: 10.1038/nature18592


Single-layer MoS2 nanopores as nanopower generators p.197

Blue energy is a desirable renewable resource, involving the osmotic transport of ions through a membrane from seawater to fresh water; here, nanopores have been created in two-dimensional molybdenum-disulfide membranes, and shown to generate a substantial osmotic power output.

doi: 10.1038/nature18593


Abrupt plate accelerations shape rifted continental margins p.201

By applying a new geotectonic analysis technique to revised global plate reconstructions, rifted margins are shown to feature an initial slow rift phase followed by an abrupt increase of plate divergence prior to breakup.

doi: 10.1038/nature18319


Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility p.205

Reconstruction of the evolutionary history of the chromosome 16p11.2 locus and identification of bolA family member 2 (BOLA2) as a gene duplicated exclusively in Homo sapiens.

doi: 10.1038/nature19075


A trans-synaptic nanocolumn aligns neurotransmitter release to receptors p.210

Synaptic vesicle fusion, as evoked by action potentials, is confined to presynaptic protein nanoclusters, which are closely aligned with concentrated postsynaptic receptors and their scaffolding proteins—an organization termed a ‘nanocolumn’.

doi: 10.1038/nature19058

がん:腫瘍細胞が誘導するdeath receptor 6を介した内皮細胞のネクロトーシスは転移を促進する

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis p.215

Human and murine tumour cells induce programmed necrosis (necroptosis) of endothelial cells, which promotes tumour cell extravasation and metastasis.

doi: 10.1038/nature19076


Global profiling of SRP interaction with nascent polypeptides p.219

Here, the selection of substrates by the protein–RNA complex known as the signal recognition particle (SRP) is investigated in the bacterium Escherichia coli, revealing that the SRP has a strong preference for hydrophobic transmembrane domains of inner membrane proteins.

doi: 10.1038/nature19070


Cotranslational signal-independent SRP preloading during membrane targeting p.224

The signal recognition particle (SRP) preferentially binds peptides destined for secretion before peptide-targeting signals are translated through recognition of elements in their mRNA, including non-coding sequences.

doi: 10.1038/nature19309


Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 p.229

Structural data on the protein CASTOR1 reveal how the mTORC1 pathway senses intracellular arginine, suggesting a repurposing of an evolutionarily pre-metazoan mechanism.

doi: 10.1038/nature19079


Reconstruction of bacterial transcription-coupled repair at single-molecule resolution p.234

Single-molecule assays show that the recruitment of UvrA and UvrAB to Mfd–RNA polymerase complex formed on a DNA lesion arrests the translocating complex and causes its dissolution.

doi: 10.1038/nature19080

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