The next steps on Zika p.5

With birth defects blamed on the virus now deemed a matter of international concern, researchers must work fast to assess the extent of the threat.

doi: 10.1038/530005a


Green growth p.6

US policymakers must set aside their divisions and give climate research a much-needed boost.

doi: 10.1038/530006a


Better together p.6

The European Union has its issues, but a Brexit could spell problems for science.

doi: 10.1038/530006b



Zika virus: Brazil's surge in small-headed babies questioned by report p.13

Organization says spike might be the result of heightened awareness because of possible link to Zika — but not everyone agrees.

doi: 10.1038/nature.2016.19259


Academics across Europe join ‘Brexit’ debate p.15

If the United Kingdom leaves the EU, researchers throughout the bloc will feel the effects.

doi: 10.1038/530015a


University seeks private donations to offset climate funding crunch p.16

Columbia courts philanthropic benefactors to support research in impacts and adaptation.

doi: 10.1038/nature.2016.19260


Drugmakers target depression’s cognitive fog p.17

Industry and researchers push for ways to assess memory and concentration deficits.

doi: 10.1038/530017a


Germany’s science hubs win in major research revamp p.18

Research clusters emerge as the big success of Germany’s Excellence Initiative — despite its focus on elite institutes.

doi: 10.1038/530018a


UK scientists gain licence to edit genes in human embryos p.18

Team at Francis Crick Institute permitted to use CRISPR–Cas9 technology in embryos for early-development research.

doi: 10.1038/nature.2016.19270

News Features


The mystery of the expanding tropics p.20


doi: 10.1038/530020a


Meet the soft, cuddly robots of the future p.24


doi: 10.1038/530024a

News & Views


Electrochemistry: Photocatalysts in close-up p.36


doi: 10.1038/530036a


Ageing: A stretch in time p.37


doi: 10.1038/nature16873


Parkinson's disease: Disorder in the court p.38


doi: 10.1038/nature16871


Optical physics: Ultrashort light pulses shake atoms p.41


doi: 10.1038/530041a


Cancer: Fibroblasts for all seasons p.42


doi: 10.1038/530042a


Phylogeny: A home for Xenoturbella p.43


doi: 10.1038/530043a



Structural disorder of monomeric α-synuclein persists in mammalian cells p.45

Atomic resolution in-cell NMR and EPR spectroscopy show that the human amyloid protein α-synuclein remains disordered within all mammalian cells tested, including neurons, and identifies which parts of the protein dynamically interact or remain shielded from the cytoplasm, thus counteracting aggregation under physiological cell conditions.

doi: 10.1038/nature16531


Persistent HIV-1 replication maintains the tissue reservoir during therapy p.51

By examining viral sequences in lymphoid tissue from three HIV-1-infected individuals receiving drug therapy, the authors find phylogenetic evidence for ongoing virus replication, suggesting that the antiretroviral drug concentration in the lymphoid tissue is insufficient to fully suppress the virus; using a mathematical model, they further explain why drug resistance does not necessarily arise as a result.

doi: 10.1038/nature16933


Active medulloblastoma enhancers reveal subgroup-specific cellular origins p.57

Genomic studies of the paediatric brain tumour medulloblastoma have revealed four clinically distinct molecular subgroups; here active gene regulatory elements in 28 primary medulloblastoma tissues are mapped to reveal differentially regulated enhancers across the different subgroups, allowing insights into the transcription factors that characterize subgroup divergence and the cellular origin of the poorly characterized Group 3 and 4 subgroups.

doi: 10.1038/nature16546



A homogeneous nucleus for comet 67P/Churyumov–Gerasimenko from its gravity field p.63

The precise mass, bulk density, porosity and internal structure of the nucleus of comet 67P/Churyumov–Gerasimenko are calculated, on the basis of its gravity field, showing it to be dusty, homogeneous, low-density and highly porous.

doi: 10.1038/nature16535


Optical attosecond pulses and tracking the nonlinear response of bound electrons p.66

Intense light pulses in the visible and adjacent spectral ranges with their energy mostly confined to a half wave cycle—optical attosecond pulses—are synthesized and used to measure the time it takes electrons to respond to light.

doi: 10.1038/nature16528


Bioresorbable silicon electronic sensors for the brain p.71

Electronic implants are often used in diagnosing and treating human illness, but permanent implants come with problems; here, devices are described that can sense temperature, pressure, pH or thermal characteristics, and—crucially—are fully resorbable by the body.

doi: 10.1038/nature16492


Sub-particle reaction and photocurrent mapping to optimize catalyst-modified photoanodes p.77

Using single-molecule fluorescence imaging of photoelectrocatalysis, the charge-carrier activities on single TiO2 nanorods and the corresponding water-oxidation photocurrent are mapped at high spatiotemporal resolution, revealing the best catalytic sites and the most effective sites for depositing an oxygen evolution catalyst.

doi: 10.1038/nature16534


Dehydration of lawsonite could directly trigger earthquakes in subducting oceanic crust p.81

Deformation experiments on lawsonite reveal that unstable fault slip occurs during dehydration reactions with continuous acoustic emission signals; this indicates the potential for unstable frictional sliding in natural lawsonite layers, which could possibly be the source of intermediate-depth earthquakes in cold subduction zones.

doi: 10.1038/nature16501


Historical nectar assessment reveals the fall and rise of floral resources in Britain p.85

Historical assessment of nectar provision in the UK from the 1930s to 2007 shows an initial dramatic fall, but more recently nectar provision has increased; the diversity of nectar sources has fallen to the point that four species now produce half of the total UK nectar.

doi: 10.1038/nature16532


Xenacoelomorpha is the sister group to Nephrozoa p.89

Robust phylogenetic analysis based on transcriptomes of Xenoturbella and acoelomorph worms shows that Xenacoelomorpha is an early bilaterian lineage forming the sister group to Nephrozoa.

doi: 10.1038/nature16520


New deep-sea species of Xenoturbella and the position of Xenacoelomorpha p.94

Description of four new species of Xenoturbella and phylogenomic analyses, aligning Xenacoelomorpha as sister group to the rest of Bilateria, or as sister to Protostomia.

doi: 10.1038/nature16545


Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2 p.98

Lentivirus-based transgenic Macaca fascicularis monkeys are generated expressing the human MECP2 transgene in the brain, and they display behavioural alterations including changes in social interaction and increased anxiety; germline transmission of the transgene to the F1 offspring is shown, and these monkeys also had an altered social interaction phenotype.

doi: 10.1038/nature16533

複雑ネットワーク:線虫Caenorhabditis elegansの老化における時間尺度の変化

The temporal scaling of Caenorhabditis elegans ageing p.103

A diverse range of molecular and genetic manipulations all alter lifespan distributions of Caenorhabditis elegans by an apparent stretching or shrinking of time.

doi: 10.1038/nature16550


An essential receptor for adeno-associated virus infection p.108

An adeno-associated virus (AAV) receptor protein essential for AAV2 entry into cells is identified; AAV receptor binds directly to the virus, and its ablation renders a diverse range of mammalian cell types and mice resistant to infection by AAV of multiple serotypes.

doi: 10.1038/nature16465


Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells p.113

Genome-wide binding profiles for eight different chromatin remodellers in mouse embryonic stem (ES) cells are determined at single nucleosome resolution; each remodeller binds at specific nucleosome positions relative to the start of genes, and the same remodeller acts as a positive or negative regulator of transcription depending on the promoter chromatin organization and epigenetic marking of the gene it binds.

doi: 10.1038/nature16505

「Journal home」に戻る