Volume 517 Number 7535



Down to earth p.411

A concerted focus on soils will benefit society in untold ways and should be embraced.

doi: 10.1038/517411b


Kept on a leash p.411

A vital dependence on genetically modified organisms on an artificial nutrient could be a means of preventing their escape into the environment.

doi: 10.1038/517411a


Lost and found p.412

The discovery of Beagle 2 on Mars should spur the search for other items lost to science.

doi: 10.1038/517412a



Attempts to predict terrorist attacks hit limits p.419

Erratic human behaviour and incomplete information plague efforts to model risk.

doi: 10.1038/517419a


Psychologists seek roots of terror p.420

Studies raise prospect of intervention in the radicalization process.

doi: 10.1038/517420a


Crunch time for pet theory on dark matter p.422

Thought to make up the Universe’s missing matter, WIMPs are running out of places to hide.

doi: 10.1038/517422a


GM microbes created that can’t escape the lab p.423

Engineered bacteria kept in check with a designer diet.

doi: 10.1038/517423a


CalWater 2015 targets atmospheric rivers off California p.424

Meteorologists investigate airborne jets that bring both floods and drought relief.

doi: 10.1038/517424a

News Features


Ageing research: Blood to blood p.426


doi: 10.1038/517426a


Astronomy: Laser focus p.430

米国カリフォルニア大学サンタクルーズ校の天文学者Claire Maxは、レーザー照射を利用した補償光学によって、望遠鏡の性能を大きく様変わりさせた。

doi: 10.1038/517430a

News & Views


Catalysis: Gold unleashes the power of three p.440


doi: 10.1038/517440a


Cell division: Hold on and let go p.441


doi: 10.1038/nature14087


Antibiotics: An irresistible newcomer p.442


doi: 10.1038/nature14193


Astronomy: Cosmic fog and smog p.444


doi: 10.1038/517444a


Palaeoclimate: Monsoon matters p.445


doi: 10.1038/517445a


Cell biology: On the endocytosis rollercoaster p.446


doi: 10.1038/nature14081



Stable gold(III) catalysts by oxidative addition of a carbon–carbon bond p.449

The facile synthesis of a stable Au(III) cationic complex is described; this gold catalyst exhibits hard, oxophilic Lewis acidity, enabling selective conjugate additions and a [2 + 2] cycloaddition reaction.

doi: 10.1038/nature14104


A new antibiotic kills pathogens without detectable resistance p.455

From a new species of β-proteobacteria, an antibiotic called teixobactin that does not generate resistance has been characterized; the antibiotic has two different lipid targets in different bacterial cell wall synthesis components, which may explain why resistance was not observed.

doi: 10.1038/nature14098


Endophilin marks and controls a clathrin-independent endocytic pathway p.460

This study describes a fast, clathrin-independent endocytic pathway mediated by endophilin, dynamin and actin; the pathway is activated by ligand binding to a variety of cargo receptors, and endophilin-mediated endocytosis occurs primarily at the leading edges of cells where lamellipodin and the lipid PtdIns(3,4)P2 ensure endophilin targeting.

doi: 10.1038/nature14067


Meikin is a conserved regulator of meiosis-I-specific kinetochore function p.466

The long elusive mammalian meiosis-specific kinetochore factor has been identified in mice; MEIKIN—which plays an equivalent role to the yeast proteins Spo13 and Moa1—ensures mono-orientation, protects sister chromatid cohesion and recruits the kinase PLK1 to the kinetochores.

doi: 10.1038/nature14097



Long-lived magnetism from solidification-driven convection on the pallasite parent body p.472

Nanomagnetic imaging has been used to obtain a palaeomagnetic time series of two pallasite meteorites, revealing that their convection was driven by core solidification, which would have caused long-lived magnetic fields in the cores of early Solar System planetary bodies.

doi: 10.1038/nature14114


Compositional engineering of perovskite materials for high-performance solar cells p.476

Inorganic–organic lead halide perovskite could be efficient when used as the light-harvesting component of solar cells; here incorporation of methylammonium lead bromide into formamidinium lead iodide stabilizes the perovskite and improves the power conversion efficiency of the solar cell up to 17.9 per cent.

doi: 10.1038/nature14133


Probabilistic reanalysis of twentieth-century sea-level rise p.481

A statistical reassessment of the tide gauge record concludes that sea level rose at a rate of about 1.2 millimetres per year from 1901 to 1990, slightly lower than prior estimates and now consistent with estimates based on individual contributions to sea-level change; the estimates reported here from 1990 onwards are consistent with other work, suggesting that the recent acceleration in sea-level rise is greater than previously thought.

doi: 10.1038/nature14093


A basal ichthyosauriform with a short snout from the Lower Triassic of China p.485

The Ichthyopterygia appeared in the fossil record as fully evolved, aquatic creatures, with nothing known about their transition from land to water, but now some light is shed on this transition by a fossil from the Lower Triassic of southern China of a small, primitive and possibly amphibious ichthyosaur-like creature, close to the common ancestry of ichthyosaurs and the obscure Hupehsuchia, a group of extinct aquatic reptiles known only from southern China.

doi: 10.1038/nature13866


The mutational landscapes of genetic and chemical models of Kras-driven lung cancer p.489

Whole-exome sequencing is used to compare the mutational landscape of adenomas from three mouse models of non-small-cell lung cancer, induced either by exposure to carcinogens or by genetic mutation of Kras; the results reveal that the two types of tumour have different mutational profiles and adopt different routes to tumour development.

doi: 10.1038/nature13898


Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis p.493

Endophilin-A2 (endoA2) is shown to mediate clathrin-independent endocytosis of Shiga and cholera toxins, and to function in parallel with dynamin and actin in the pulling-force-driven scission of Shiga-toxin-induced tubular structures.

doi: 10.1038/nature14064


mTORC1-mediated translational elongation limits intestinal tumour initiation and growth p.497

The mTORC1 complex has been implicated in tumorigenesis owing partially to its ability to increase protein translation; now, mTORC1 activity in the mouse intestine is shown not to be required for normal homeostasis but to be necessary for the triggering of tumorigenesis by APC mutations, suggesting that it could be a good target for the prevention of colorectal cancer in high-risk patients.

doi: 10.1038/nature13896


IgG1 protects against renal disease in a mouse model of cryoglobulinaemia p.501

Here, the predominant murine immunoglobulin G subclass, IgG1, which is a poor activator of effector mechanisms, is shown to have a regulatory function, protecting against the development of IgG3 immune-complex-driven renal disease by competing with IgG3 for antigen and increasing immune complex solubility.

doi: 10.1038/nature13868

構造生物学:完全なウイルス粒子中の未成熟HIV-1キャプシドの分解能8.8 Åでの構造

Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution p.505

Cryo-electron tomography and subtomogram averaging methods reveal the structure of the capsid lattice within intact heterogeneous immature HIV-1 particles.

doi: 10.1038/nature13838


Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB p.509

Structural and biochemical studies show that the biosynthesis of the food preservative nisin involves the tRNA-dependent glutamylation of serine and threonine.

doi: 10.1038/nature13888


Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation p.513

X-ray crystallography and EPR spectroscopy are used to characterize a soluble, oxygen-tolerant reductive dehalogenase from Nitratireductor pacific us pht-3B; the data suggest that the cobalt in the cobalamin cofactor ligates the halogen atom of the substrate, directly abstracting the halogen atom via an oxidative addition.

doi: 10.1038/nature13901

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