Volume 514 Number 7523



The ice bucket p.403

Social-media fun for medical research bypasses animal sensitivities.

doi: 10.1038/514403b


A ripe time for gaining ground p.403

After three years of heated debate, the advocates and critics of gain-of-function research must work to agree on how best to regulate the work.

doi: 10.1038/514403a


Toxic influence p.404

Europe must act to stop livestock drugs from wiping out its vulture populations.

doi: 10.1038/514404a



US suspends risky disease research p.411

Government to cease funding gain-of-function studies that make viruses more dangerous, pending a safety assessment.

doi: 10.1038/514411a


US midterm elections offer little hope for science p.412

November vote is unlikely to break a political stalemate that has squeezed research funding.

doi: 10.1038/514412a


Oldest-known human genome sequenced p.413

DNA shows a group of modern humans roamed across Asia.

doi: 10.1038/514413a


Sun’s stroke keeps Kepler online p.414

Space telescope beats mechanical failures to begin a second mission that will trace new celestial targets.

doi: 10.1038/514414a


Data bank struggles as protein imaging ups its game p.416

Hybrid methods to solve structures of molecular machines create a storage headache.

doi: 10.1038/514416a

News Features


Human-subjects research: The ethics squad p.418


doi: 10.1038/514418a


The discovery of Homo floresiensis: Tales of the hobbit p.422


doi: 10.1038/514422a

News & Views


Climate change: A crack in the natural-gas bridge p.436


doi: 10.1038/nature13927


HIV: A stamp on the envelope p.437


doi: 10.1038/nature13926


Lung disease: Treatment by cell transplant p.438


doi: 10.1038/nature13758


Astronomy: Hurling comets around a planetary nursery p.440


doi: 10.1038/514440a


Physiology: Relax and come in p.441


doi: 10.1038/514441a


HIV: Potency needs constancy p.442


doi: 10.1038/514442a



Genome sequence of a 45,000-year-old modern human from western Siberia p.445

The high-quality genome sequence of a 45,000-year-old modern human from Siberia reveals that gene flow from Neanderthals into the ancestors of this individual had already occurred about 7,000 to 13,000 years earlier; genomic comparisons show that he belonged to a population that lived close in time to the separation of populations in east and west Eurasia and that may represent an early modern human radiation out of Africa that has no direct descendants today.

doi: 10.1038/nature13810


Pulmonary macrophage transplantation therapy p.450

This study reports the correction of pulmonary alveolar proteinosis (PAP) in Csf2rb–/– mice by a single transfer of either wild-type or gene-corrected macrophages directly to the lungs — the transplanted macrophages persisted for at least 1 year; this transplantation strategy obviated the need for myeloablation and immunosuppression and should be a feasible therapy for humans with hereditary PAP.

doi: 10.1038/nature13807

構造生物学:融合前のHIV-1 Env三量体の構造と免疫認識

Structure and immune recognition of trimeric pre-fusion HIV-1 Env p.455

A crystal structure of the human immunodeficiency virus Env trimer, used by the virus to infect cells, is determined here; the new structure, which shows the pre-fusion form of Env, increases our understanding of the fusion mechanism and of how the conformation of Env allows the virus to evade the immune response.

doi: 10.1038/nature13808



Two families of exocomets in the β Pictoris system p.462

The young planetary system surrounding the star β Pictoris harbours active minor bodies. These asteroids and comets produce a large amount of dust and gas through collisions and evaporation, as happened early in the history of our Solar System. Spectroscopic observations of β Pictoris reveal a high rate of transits of small evaporating bodies, that is, exocomets. Here we report an analysis of more than 1,000 archival spectra gathered between 2003 and 2011, which provides a sample of about 6,000 variable absorption signatures arising from exocomets transiting the disk of the parent star. Statistical analysis of the observed properties of these exocomets allows us to identify two populations with different physical properties. One family consists of exocomets producing shallow absorption lines, which can be attributed to old exhausted (that is, strongly depleted in volatiles) comets trapped in a mean motion resonance with a massive planet. Another family consists of exocomets producing deep absorption lines, which may be related to the recent fragmentation of one or a few parent bodies. Our results show that the evaporating bodies observed for decades in the β Pictoris system are analogous to the comets in our own Solar System.

doi: 10.1038/nature13849


Characterizing and predicting the magnetic environment leading to solar eruptions p.465

Modelling the solar magnetic field using observations of the photospheric field in the four-day period preceding a coronal mass ejection shows that the formation and later ejection of a twisted rope of magnetic flux provides the physical mechanism responsible for the ejection.

doi: 10.1038/nature13815


Piezoelectricity of single-atomic-layer MoS2 for energy conversion and piezotronics p.470

The two-dimensional semiconducting material molybdenum disulphide shows strong piezoelectricity in its single-layered form, suggesting possible applications in nanoscale electromechanical devices for sensing and energy harvesting.

doi: 10.1038/nature13792


Identification of an iridium-containing compound with a formal oxidation state of IX p.475

The tetrahedral iridium tetroxide cation [IrO4]+, which has an iridium 5d0 valence electron configuration and a formal oxidation state of IX, is generated in the gas phase, identified by infrared photodissociation spectroscopy, and predicted, by quantum chemical calculations, to be the most stable of all possible [IrO4]+ isomers.

doi: 10.1038/nature13795


Methane dynamics regulated by microbial community response to permafrost thaw p.478

The abundance of key microbial lineages can be used to predict atmospherically relevant patterns in methane isotopes and the proportion of carbon metabolized to methane during permafrost thaw, suggesting that microbial ecology may be important in ecosystem-scale responses to global change.

doi: 10.1038/nature13798


Limited impact on decadal-scale climate change from increased use of natural gas p.482

It has been hoped that making abundant natural gas available by hydraulic fracturing (fracking) would reduce greenhouse gas emissions but now modelling shows that increased consumption will have limited effect on climate change.

doi: 10.1038/nature13837


Producing more grain with lower environmental costs p.486

In an experiment across China to test integrated soil–crop system management for rice, wheat and maize against current practice, improvements in grain yield are equivalent to high-input techniques, but nutrient use, nutrient loss and greenhouse gas emissions are lower than current practice.

doi: 10.1038/nature13609


A Hox regulatory network of hindbrain segmentation is conserved to the base of vertebrates p.490

Nested Hox expression domains are found in jawed vertebrates and in non-vertebrate chordates, but it is unclear whether there is a link between brain regionalization and Hox expression in jawless vertebrates; here, Hox expression is shown to be integrated with hindbrain segmentation in lampreys.

doi: 10.1038/nature13723


Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis p.494

Three 1,000-year-old mycobacterial genomes from Peruvian human skeletons reveal that a member of the Mycobacterium tuberculosis complex derived from seals caused human disease before contact in the Americas.

doi: 10.1038/nature13591


Dendritic cells control fibroblastic reticular network tension and lymph node expansion p.498

During inflammation, the lymph node stromal compartment is shown to accommodate high numbers of infiltrating lymphocytes by relaxing the cytoskeleton of fibroblastic reticular cells, allowing the latter to stretch and the lymph node to expand.

doi: 10.1038/nature13814


Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers p.503

Total or near-total loss of insulin-producing β-cells occurs in type 1 diabetes. Restoration of insulin production in type 1 diabetes is thus a major medical challenge. We previously observed in mice in which β-cells are completely ablated that the pancreas reconstitutes new insulin-producing cells in the absence of autoimmunity. The process involves the contribution of islet non-β-cells; specifically, glucagon-producing α-cells begin producing insulin by a process of reprogramming (transdifferentiation) without proliferation. Here we show the influence of age on β-cell reconstitution from heterologous islet cells after near-total β-cell loss in mice. We found that senescence does not alter α-cell plasticity: α-cells can reprogram to produce insulin from puberty through to adulthood, and also in aged individuals, even a long time after β-cell loss. In contrast, before puberty there is no detectable α-cell conversion, although β-cell reconstitution after injury is more efficient, always leading to diabetes recovery. This process occurs through a newly discovered mechanism: the spontaneous en masse reprogramming of somatostatin-producing δ-cells. The juveniles display ‘somatostatin-to-insulin’ δ-cell conversion, involving dedifferentiation, proliferation and re-expression of islet developmental regulators. This juvenile adaptability relies, at least in part, upon the combined action of FoxO1 and downstream effectors. Restoration of insulin producing-cells from non-β-cell origins is thus enabled throughout life via δ- or α-cell spontaneous reprogramming. A landscape with multiple intra-islet cell interconversion events is emerging, offering new perspectives for therapy.

doi: 10.1038/nature13633


High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity p.508

A high-fat diet promotes intestinal tumorigenesis independently of obesity in a mouse model with oncogene activation, by changing the composition of the gut microbiota and altering immune regulation.

doi: 10.1038/nature13398


Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia p.513

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a poor prognosis and no available targeted therapies; now two histone H3 lysine 27 demethylases, JMJD3 and UTX, are shown to have contrasting roles in human T-ALL cells and a mouse model of the disease, and a small molecule demethylase inhibitor is found to inhibit the growth of T-ALL cell lines, introducing a potential therapeutic avenue for acute leukaemia.

doi: 10.1038/nature13605


Structure and mechanism of Zn2+-transporting P-type ATPases p.518

Zinc is an essential micronutrient for all living organisms. It is required for signalling and proper functioning of a range of proteins involved in, for example, DNA binding and enzymatic catalysis. In prokaryotes and photosynthetic eukaryotes, Zn2+-transporting P-type ATPases of class IB (ZntA) are crucial for cellular redistribution and detoxification of Zn2+ and related elements. Here we present crystal structures representing the phosphoenzyme ground state (E2P) and a dephosphorylation intermediate (E2·Pi) of ZntA from Shigella sonnei, determined at 3.2 Å and 2.7 Å resolution, respectively. The structures reveal a similar fold to Cu+-ATPases, with an amphipathic helix at the membrane interface. A conserved electronegative funnel connects this region to the intramembranous high-affinity ion-binding site and may promote specific uptake of cellular Zn2+ ions by the transporter. The E2P structure displays a wide extracellular release pathway reaching the invariant residues at the high-affinity site, including C392, C394 and D714. The pathway closes in the E2·Pi state, in which D714 interacts with the conserved residue K693, which possibly stimulates Zn2+ release as a built-in counter ion, as has been proposed for H+-ATPases. Indeed, transport studies in liposomes provide experimental support for ZntA activity without counter transport. These findings suggest a mechanistic link between PIB-type Zn2+-ATPases and PIII-type H+-ATPases and at the same time show structural features of the extracellular release pathway that resemble PII-type ATPases such as the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) and Na+, K+-ATPase. These findings considerably increase our understanding of zinc transport in cells and represent new possibilities for biotechnology and biomedicine.

doi: 10.1038/nature13618

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