No place for bullies in science p.151

High-profile allegations of bullying at a German research institute highlight the need for better systems to protect young scientists.

doi: 10.1038/d41586-018-05683-z


From artists to scientists, anyone can have a successful streak at any time p.151

Science offers renewed hope for those still waiting for their moment in the spotlight.

doi: 10.1038/d41586-018-05682-0


Governments must weigh the environmental costs of deep-sea mining p.152

Key meeting should focus minds on the best way to extract minerals from the depths of the ocean.

doi: 10.1038/d41586-018-05681-1



Max Planck astrophysicist at centre of bullying allegations speaks up p.159

Top German institute plans to release results of a survey that will shed light on bullying issues.

doi: 10.1038/d41586-018-05634-8


Foreign-researcher figures stress need for immigration reform before Brexit p.160

EU researchers would overwhelm existing visa system and should retain special access to the United Kingdom, say science organizations.

doi: 10.1038/d41586-018-05632-w


Coming soon to a lab near you? Genetically modified cannabis p.162

Scientists might be able to draw from new sources of cannabis compounds for research.

doi: 10.1038/d41586-018-05659-z


Software beats animal tests at predicting toxicity of chemicals p.163

Machine learning on mountain of safety data improves automated assessments.

doi: 10.1038/d41586-018-05664-2


Controversial CRISPR ‘gene drives’ tested in mammals for the first time p.164

Experiments in mice suggest that the technology has a long way to go before being used for pest control in the wild.

doi: 10.1038/d41586-018-05665-1

News Features


100 bats and a long, dark tunnel: one neuroscientist’s quest to unlock the secrets of 3D navigation p.165

イスラエル・ワイツマン科学研究所の神経科学者Nachum Ulanovskyは、オオコウモリと200 mにも及ぶ長いトンネルを使って、脳の空間ナビゲーションの仕組みを調べている。

doi: 10.1038/d41586-018-05648-2

News & Views


Synthetic biology: Self-organizing multicellular structures designed using synthetic biology p.184


doi: 10.1038/d41586-018-05564-5


Palaeoclimate: A fresh take on ancient climate change in the North Pacific p.185


doi: 10.1038/d41586-018-05614-y


DNA damage: Superfast DNA replication causes damage in cancer cells p.186


doi: 10.1038/d41586-018-05501-6


Public health: Estimate suggests many infant deaths in sub-Saharan Africa attributable to air pollution p.188


doi: 10.1038/d41586-018-05394-5


Condensed-matter physics: The heat is on for Majorana fermions p.189


doi: 10.1038/d41586-018-05637-5


Ecology: How rats wreak havoc on coral reefs p.190


doi: 10.1038/d41586-018-05355-y



China’s response to a national land-system sustainability emergency p.193

China has addressed widespread rural poverty and environmental degradation head-on via unprecedented investment in sixteen large-scale sustainability programmes.

doi: 10.1038/s41586-018-0280-2



Observation of half-integer thermal Hall conductance p.205

Measurements of the thermal Hall conductance in the first excited Landau level of the quantum Hall effect show the existence of a state with non-Abelian excitations.

doi: 10.1038/s41586-018-0184-1


Kinase-controlled phase transition of membraneless organelles in mitosis p.211

The dual-specificity kinase DYRK3 acts as a central ‘dissolvase’, mediating the phase transitions of several types of membraneless organelles during mitosis.

doi: 10.1038/s41586-018-0279-8


Structure of the origin recognition complex bound to DNA replication origin p.217

The cryo-EM structure of the yeast origin recognition complex (ORC) bound to a 72-base-pair origin DNA sequence provides insights into the basis of the origin selection mechanism.

doi: 10.1038/s41586-018-0293-x


天文学:1I/2017 U1(オウムアムア)の軌道における非重力的な加速

Non-graviational acceleration in the trajectory of 1I/2017 U1 (‘Oumuamua) p.223

‘Oumuamua—the first known interstellar object to have entered the Solar System—is probably a comet, albeit with unusual dust and chemical properties owing to its origin in a distant solar system.

doi: 10.1038/s41586-018-0254-4


Majorana quantization and half-integer thermal quantum Hall effect in a Kitaev spin liquid p.227

Half-integer quantization of the thermal Hall effect in a Kitaev spin liquid reveals chiral currents of charge-neutral Majorana fermions around the edges of the sample, produced by strong electronic correlations.

doi: 10.1038/s41586-018-0274-0


Metallic nanoparticle contacts for high-yield, ambient-stable molecular-monolayer devices p.232

A top-contacting method for the fabrication of molecular devices uses metallic nanoparticles to electrically contact self-assembled monolayers, enabling the preparation of thousands of identical, ambient-stable metal–molecule–metal devices.

doi: 10.1038/s41586-018-0275-z


Electrically controlled water permeation through graphene oxide membranes p.236

The rapid water transport through graphene oxide membranes can be switched off by introducing localized electric fields within the membranes that ionize surrounding water molecules and thus block transport.

doi: 10.1038/s41586-018-0292-y


North Pacific freshwater events linked to changes in glacial ocean circulation p.241

Sediment-core and modelling analyses suggest that, during distinct cold periods known as Heinrich Stadials, changes in ocean circulation in the North Atlantic triggered discharge of freshwater from the Cordilleran Ice Sheet into the North Pacific.

doi: 10.1038/s41586-018-0276-y


Evolution of cooperation in stochastic games p.246

Cooperation is more likely to evolve in a public-goods-distribution game when payoffs can change between rounds so that the stakes increase when players cooperate and decrease when players defect.

doi: 10.1038/s41586-018-0277-x


Seabirds enhance coral reef productivity and functioning in the absence of invasive rats p.250

Productivity of coral reefs is enhanced near islands with no invasive rats, as populations of seabirds, which transfer nitrogen from deeper areas of ocean to the nearshore waters via their guano, are much larger than on rat-infested islands.

doi: 10.1038/s41586-018-0202-3


Robust relationship between air quality and infant mortality in Africa p.254

A 10 μg m−3 increase in the concentration of ambient respirable particulate matter is associated with a 9% rise in infant mortality in Africa and this increase is not affected by household wealth.

doi: 10.1038/s41586-018-0263-3


Species-specific activity of antibacterial drug combinations p.259

Screening pairwise combinations of antibiotics and other drugs against three bacterial pathogens reveals that antagonistic and synergistic drug–drug interactions are specific to microbial species and strains.

doi: 10.1038/s41586-018-0278-9

免疫学:プリン作動性受容体P2RX7は長期生存記憶CD8+ T細胞の代謝適応性を指揮する

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells p.264

Activation of P2RX7 receptors by extracellular ATP is required for the generation, maintenance and function of central and tissue-resident CD8+ memory T cells.

doi: 10.1038/s41586-018-0282-0


Targeting STING with covalent small-molecule inhibitors p.269

The discovery and characterization of small-molecule antagonists that inhibit the stimulator of interferon genes (STING) protein may help to develop therapies for the treatment of autoinflammatory disease.

doi: 10.1038/s41586-018-0287-8


Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13 p.274

Structural analysis demonstrates how TRIP13 and p31comet disassemble the mitotic checkpoint complex.

doi: 10.1038/s41586-018-0281-1


High speed of fork progression induces DNA replication stress and genomic instability p.279

Inhibition of PARP is shown to accelerate the speed of replication fork elongation, which prevents fork stalling and induces DNA damage, with implications for genomic instability and cancer treatment.

doi: 10.1038/s41586-018-0261-5


CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions p.285

Mutations in all three genes encoding ribonuclease H2 sensitize cells to poly(ADP–ribose) polymerase inhibitors by compromising ribonucleotide excision repair.

doi: 10.1038/s41586-018-0291-z

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