Volume 557 Number 7704



The #MeToo campaign is gaining ground in China p.139

A string of cases at Chinese universities shows a system that is trying to address concerns and implement change, but still has some way to go.

doi: 10.1038/d41586-018-05075-3


Crowdsourced quantum reality-check gets crowdsourced peer review p.139

An unusual study that harnessed the public to test quantum physics offers a good example of collaborative academic review.

doi: 10.1038/d41586-018-05073-5


What to do to improve postgraduate mental health p.140

Greater awareness must be matched with steps such as better training for supervisors.

doi: 10.1038/d41586-018-05074-4



Particle physicists turn to AI to cope with CERN’s collision deluge p.147

Can a competition with cash rewards improve techniques for tracking the Large Hadron Collider’s messy collisions?

doi: 10.1038/d41586-018-05084-2


Yellowstone's grizzlies under threat from controversial hunting proposal p.148

Biologists argue that plan could endanger the bear population in the iconic ecosystem.

doi: 10.1038/d41586-018-05061-9


Report harassment or risk losing funding, says top UK science funder p.149

The Wellcome Trust vows to pull grants if researchers or institutions do not abide by its new misconduct policy.

doi: 10.1038/d41586-018-05071-7


€100-billion budget proposed for Europe’s next big research programme p.150

Initial funding plans for the seven-year Horizon Europe science initiative get a lukewarm reception.

doi: 10.1038/d41586-018-05105-0


Cancer-killing viruses show promise — and draw billion-dollar investment p.150

Encouraging trial results spur interest from researchers and drug giants.

doi: 10.1038/d41586-018-05104-1

NASAが、ほぼ絶対零度での極低温量子実験を可能にする装置Cold Atom Laboratory(CAL)を国際宇宙ステーションに設置へ。

Universe’s coolest lab set to open up quantum world p.151

NASA’s Cold Atom Laboratory will allow physicists to play with quantum phenomena like never before.

doi: 10.1038/d41586-018-05111-2

News Features


How to save the high seas p.154


doi: 10.1038/d41586-018-05079-z

News & Views


Biotechnology: From CRISPR scissors to virus sensors p.168


doi: 10.1038/d41586-018-04975-8


Neuroscience: Models of Parkinson’s disease revisited p.169


doi: 10.1038/d41586-018-02589-8


Ecology: Precarious preferences wipe out a butterfly population p.171


doi: 10.1038/d41586-018-05068-2


Particle physics: Weak charge of the proton measured p.171


doi: 10.1038/d41586-018-05037-9


Neuroscience: Connections that control defence strategy p.172


doi: 10.1038/d41586-018-04747-4


Structural biology: Detailed view of human telomerase enzyme invites rethink of its structure p.174


doi: 10.1038/d41586-018-04756-3



Diametric neural ensemble dynamics in parkinsonian and dyskinetic states p.177

In mouse models of Parkinson’s disease and dyskinesia, striatal spiny projection neurons of the direct and indirect pathways have abnormal, imbalanced levels of spontaneous and locomotor-related activity, with the two different disease states characterized by opposite abnormalities.

doi: 10.1038/s41586-018-0090-6


A midline thalamic circuit determines reactions to visual threat p.183

Separate outputs of the ventral midline thalamus comprise neural circuits that determine avoidance-based or confrontational responses to visual threat.

doi: 10.1038/s41586-018-0078-2


Cryo-EM structure of substrate-bound human telomerase holoenzyme p.190

A cryo-electron microscopy structure of the substrate-bound human telomerase holoenzyme, which lengthens the protective caps on chromosomes.

doi: 10.1038/s41586-018-0062-x


Structural basis for dual-mode inhibition of the ABC transporter MsbA p.196

Crystal structures of the ABC transporter MsbA in complex with two selective small-molecule antagonists reveal an unprecedented allosteric mechanism of inhibition.

doi: 10.1038/s41586-018-0083-5



Electron magnetic reconnection without ion coupling in Earth’s turbulent magnetosheath p.202

Observations of electron-scale current sheets in Earth’s turbulent magnetosheath reveal electron reconnection without ion coupling, contrary to expectations from the standard model of magnetic reconnection.

doi: 10.1038/s41586-018-0091-5


Precision measurement of the weak charge of the proton p.207

Measurement of the asymmetry in the parity-violating scattering of polarized electrons on protons gives the weak charge of the proton as 0.0719 ± 0.0045, in agreement with the standard model.

doi: 10.1038/s41586-018-0096-0


Challenging local realism with human choices p.212

The BIG Bell Test, which used an online video game with 100,000 participants worldwide to provide random bits to 13 quantum physics experiments, contradicts the Einstein–Podolsky–Rosen worldview of local realism.

doi: 10.1038/s41586-018-0085-3


Highly durable, coking and sulfur tolerant, fuel-flexible protonic ceramic fuel cells p.217

Tests on a versatile protonic ceramic fuel cell resistant to carbon deposition and sulfur poisoning show that its durability and the wide range of fuels it can accept make it suitable for use in industry in the near future.

doi: 10.1038/s41586-018-0082-6


Rapid energy-efficient manufacturing of polymers and composites via frontal polymerization p.223

Frontal polymerization of dicyclopentadiene is used to generate thermoset polymers and composite materials with much lower energy requirements and cure times than are needed in conventional oven or autoclave curing approaches.

doi: 10.1038/s41586-018-0054-x


Nanoscale synthesis and affinity ranking p.228

A system that combines nanoscale synthesis and affinity ranking enables high-throughput screening of reaction conditions and bioactivity for a given protein target, accelerating the process of drug discovery.

doi: 10.1038/s41586-018-0056-8


Earliest known hominin activity in the Philippines by 709 thousand years ago p.233

Stone tools and a disarticulated and butchered skeleton of Rhinoceros philippinensis, found in a securely dated stratigraphic context, indicate the presence of an unknown hominin population in the Philippines as early as 709 thousand years ago.

doi: 10.1038/s41586-018-0072-8


Lethal trap created by adaptive evolutionary response to an exotic resource p.238

Local extinction of the butterfly Euphydryas editha occurred after the population was caught in an eco-evolutionary trap set when the insects evolved unanimous preference for an exotic host, Plantago lanceolata, and sprung when that host became embedded in grasses after humans removed cattle.

doi: 10.1038/s41586-018-0074-6


Subepithelial telocytes are an important source of Wnts that supports intestinal crypts p.242

Subepithelial telocytes are identified as a source of Wnt signals that enable proliferation and differentiation of intestinal stem cells, an essential function for maintenance of the intestinal epithelium.

doi: 10.1038/s41586-018-0084-4

幹細胞:TGFβを介する肝細胞の分化転換による胆管系のde novo形成

De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation p.247

In a mouse model of a human cholestatic liver disease caused by impaired NOTCH signalling, hepatocytes transdifferentiate into cholangiocytes and form a therapeutically effective biliary system, driven by TGFβ signalling.

doi: 10.1038/s41586-018-0075-5


Male-killing toxin in a bacterial symbiont of Drosophila p.252

The Spaid protein is identified and shown to be responsible for the male-killing effects of Spiroplasma poulsonii in Drosophila.

doi: 10.1038/s41586-018-0086-2


Chromatin analysis in human early development reveals epigenetic transition during ZGA p.256

By applying an optimized ATAC-seq protocol to human early embryos, distinct accessible chromatin landscapes are found before and after zygotic genome activation, revealing a marked epigenetic transition during zygotic genome activation and putative regulatory elements wiring human early development.

doi: 10.1038/s41586-018-0080-8


Structural principles of distinct assemblies of the human α4β2 nicotinic receptor p.261

Cryo-electron microscopy structures of two stoichiometries of heteromeric acetylcholine receptors in complex with nicotine reveal principles of subunit assembly and the structural basis of the distinctive biophysical and pharmacological properties of the different stoichiometries.

doi: 10.1038/s41586-018-0081-7

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