A string of cases at Chinese universities shows a system that is trying to address concerns and implement change, but still has some way to go.
doi: 10.1038/d41586-018-05075-3
An unusual study that harnessed the public to test quantum physics offers a good example of collaborative academic review.
doi: 10.1038/d41586-018-05073-5
Greater awareness must be matched with steps such as better training for supervisors.
doi: 10.1038/d41586-018-05074-4
Can a competition with cash rewards improve techniques for tracking the Large Hadron Collider’s messy collisions?
doi: 10.1038/d41586-018-05084-2
Biologists argue that plan could endanger the bear population in the iconic ecosystem.
doi: 10.1038/d41586-018-05061-9
The Wellcome Trust vows to pull grants if researchers or institutions do not abide by its new misconduct policy.
doi: 10.1038/d41586-018-05071-7
Initial funding plans for the seven-year Horizon Europe science initiative get a lukewarm reception.
doi: 10.1038/d41586-018-05105-0
Encouraging trial results spur interest from researchers and drug giants.
doi: 10.1038/d41586-018-05104-1
NASA’s Cold Atom Laboratory will allow physicists to play with quantum phenomena like never before.
doi: 10.1038/d41586-018-05111-2
国連が、公海の生物多様性と環境の保護を目的とする初の包括的条約制定に向けて交渉を始めるが、その成功には具体的に何が必要なのか、科学的視点から考える。
doi: 10.1038/d41586-018-05079-z
2種の細菌性Casタンパク質は、特定の標的配列に結合した後、核酸を無差別に切断する。今回、この特性を利用して、ウイルスを安価に検出するための極めて感度の高い携帯型診断ツールが作られた。
doi: 10.1038/d41586-018-04975-8
従来のモデルでは、運動に正反対の影響を及ぼす2つの神経経路での活動レベルが、パーキンソン病では不均衡になると考えられている。今回、マウスの分析によってより複雑な実態が示された。
doi: 10.1038/d41586-018-02589-8
畜牛牧場の経営によって生息域に持ち込まれた植物に依存するようになったチョウの隔離個体群が、その植物の優占度が下がった後、絶滅したことが今回分かった。
doi: 10.1038/d41586-018-05068-2
陽子の弱荷は、陽子と他の素粒子の間のある種の相互作用の強さを定める。今回、この量が精密に測定され、素粒子物理学の標準模型が厳密に検証された。
doi: 10.1038/d41586-018-05037-9
脅威にさらされると、大半のマウスはすくむか隠れるが、一部のマウスはより攻撃的に反応する。今回、こうした行動の選択の根底にある脳の回路が解明された。
doi: 10.1038/d41586-018-04747-4
テロメラーゼ酵素は、染色体の端にある反復DNA配列の保護キャップを維持することによって、重要な役割を果たしている。今回、ヒトテロメラーゼの構造が分かり、そのアーキテクチャーに新たな光が当たった。
doi: 10.1038/d41586-018-04756-3
In mouse models of Parkinson’s disease and dyskinesia, striatal spiny projection neurons of the direct and indirect pathways have abnormal, imbalanced levels of spontaneous and locomotor-related activity, with the two different disease states characterized by opposite abnormalities.
doi: 10.1038/s41586-018-0090-6
Separate outputs of the ventral midline thalamus comprise neural circuits that determine avoidance-based or confrontational responses to visual threat.
doi: 10.1038/s41586-018-0078-2
A cryo-electron microscopy structure of the substrate-bound human telomerase holoenzyme, which lengthens the protective caps on chromosomes.
doi: 10.1038/s41586-018-0062-x
Crystal structures of the ABC transporter MsbA in complex with two selective small-molecule antagonists reveal an unprecedented allosteric mechanism of inhibition.
doi: 10.1038/s41586-018-0083-5
Observations of electron-scale current sheets in Earth’s turbulent magnetosheath reveal electron reconnection without ion coupling, contrary to expectations from the standard model of magnetic reconnection.
doi: 10.1038/s41586-018-0091-5
Measurement of the asymmetry in the parity-violating scattering of polarized electrons on protons gives the weak charge of the proton as 0.0719 ± 0.0045, in agreement with the standard model.
doi: 10.1038/s41586-018-0096-0
The BIG Bell Test, which used an online video game with 100,000 participants worldwide to provide random bits to 13 quantum physics experiments, contradicts the Einstein–Podolsky–Rosen worldview of local realism.
doi: 10.1038/s41586-018-0085-3
Tests on a versatile protonic ceramic fuel cell resistant to carbon deposition and sulfur poisoning show that its durability and the wide range of fuels it can accept make it suitable for use in industry in the near future.
doi: 10.1038/s41586-018-0082-6
Frontal polymerization of dicyclopentadiene is used to generate thermoset polymers and composite materials with much lower energy requirements and cure times than are needed in conventional oven or autoclave curing approaches.
doi: 10.1038/s41586-018-0054-x
A system that combines nanoscale synthesis and affinity ranking enables high-throughput screening of reaction conditions and bioactivity for a given protein target, accelerating the process of drug discovery.
doi: 10.1038/s41586-018-0056-8
Stone tools and a disarticulated and butchered skeleton of Rhinoceros philippinensis, found in a securely dated stratigraphic context, indicate the presence of an unknown hominin population in the Philippines as early as 709 thousand years ago.
doi: 10.1038/s41586-018-0072-8
Local extinction of the butterfly Euphydryas editha occurred after the population was caught in an eco-evolutionary trap set when the insects evolved unanimous preference for an exotic host, Plantago lanceolata, and sprung when that host became embedded in grasses after humans removed cattle.
doi: 10.1038/s41586-018-0074-6
Subepithelial telocytes are identified as a source of Wnt signals that enable proliferation and differentiation of intestinal stem cells, an essential function for maintenance of the intestinal epithelium.
doi: 10.1038/s41586-018-0084-4
In a mouse model of a human cholestatic liver disease caused by impaired NOTCH signalling, hepatocytes transdifferentiate into cholangiocytes and form a therapeutically effective biliary system, driven by TGFβ signalling.
doi: 10.1038/s41586-018-0075-5
The Spaid protein is identified and shown to be responsible for the male-killing effects of Spiroplasma poulsonii in Drosophila.
doi: 10.1038/s41586-018-0086-2
By applying an optimized ATAC-seq protocol to human early embryos, distinct accessible chromatin landscapes are found before and after zygotic genome activation, revealing a marked epigenetic transition during zygotic genome activation and putative regulatory elements wiring human early development.
doi: 10.1038/s41586-018-0080-8
Cryo-electron microscopy structures of two stoichiometries of heteromeric acetylcholine receptors in complex with nicotine reveal principles of subunit assembly and the structural basis of the distinctive biophysical and pharmacological properties of the different stoichiometries.
doi: 10.1038/s41586-018-0081-7
