Integrity starts with the health of research groups p.5
Funders should force universities to support laboratories’ research health.
doi: 10.1038/545005b
Funders should force universities to support laboratories’ research health.
doi: 10.1038/545005b
Delay in making presidential appointments harms research and the broader public.
doi: 10.1038/545005a
The apparent slowdown in global warming has provided a spur for better understanding of the underlying processes.
doi: 10.1038/545006a
Alfredo Fusco denies claims that his research lab hired a photo studio to manipulate images.
doi: 10.1038/545013a
Ancient rock art research could piece together how the peoples who lived in the region some 5,700 years ago interacted.
doi: 10.1038/545014a
Scientists offer more detail on flagship programme to harness quantum effects in devices.
doi: 10.1038/545016a
Ketamine can ease depression in hours, but researchers might have misjudged how it works.
doi: 10.1038/545017a
Money will be used to develop open-source platform and help put articles in web-friendly formats.
doi: 10.1038/nature.2017.21894
An experimental procedure is exposing the links between the nervous and immune systems. Could it be the start of a revolution?
doi: 10.1038/545020a
A revised timeline for the arrival of settlers on Mangaia island in Polynesia reveals the resilience of this population, which overcame an environmental crisis through bold measures to support a sustainable society.
doi: 10.1038/545032a
Mutant proteins that contain stretches called polyQ repeats can misfold or form aggregates linked to neurodegeneration. It emerges that some polyQ-containing proteins regulate a process that degrades misfolded proteins. See Letter p.108
doi: 10.1038/nature22489
Hydrocarbons called alkenes are isolated from petroleum as mixtures of isomers, often making it hard to use them as reagents for synthesis. A reaction involving a migrating nickel atom offers a possible solution. See Letter p.84
doi: 10.1038/545035a
Two studies of the molecular chaperone protein HSP90 reveal how complex traits can be shaped by genetic and environmental context. This work highlights the challenges of personalized medicine.
doi: 10.1038/nature22487
Short-term climate trends are sensitive to definitions, data and testing. This sensitivity underlies an alleged pause in global warming, and highlights the need for meaningful definitions to sustain claims that it was real. See Analysis p.41
doi: 10.1038/545037a
Two studies integrate cutting-edge techniques to grow and analyse 3D cultured tissues that resemble human brain structures, enabling examination of how brain regions interact and neurons mature. See Articles p.48 & p.54
doi: 10.1038/545039a
Apparently contradictory conclusions regarding the ‘global warming hiatus’ are reconciled, strengthening the current scientific understanding that long-term global warming is extremely likely to be of anthropogenic origin.
doi: 10.1038/nature22315
Apparently contradictory conclusions regarding the ‘global warming hiatus’ are reconciled, strengthening the current scientific understanding that long-term global warming is extremely likely to be of anthropogenic origin.
doi: 10.1038/nature22047
Human pluripotent stem cells were used to develop dorsal and ventral forebrain 3D spheroids, which can be assembled to study interneuron migration and to derive a functionally integrated forebrain system with cortical interneurons and glutamatergic neurons.
doi: 10.1038/nature22330
The clinical benefit of anti-PD-1 antibody treatment is dependent on the extent to which exhausted CD8 T cells are reinvigorated in relation to the tumour burden of the patient.
doi: 10.1038/nature22079
Multiple crystallographic structures of a concentrative nucleoside transporter show how it uses an ‘elevator’ mechanism to move its transport domain across the membrane.
doi: 10.1038/nature22057
In a quantum dot in the Kondo regime, electrical charges are effectively frozen, but the quantum dot remains electrically conducting owing to strong electron–electron correlations.
doi: 10.1038/nature21704
Quasiparticles in strongly interacting fractional quantum Hall systems carry heat according to the same quantization of thermal conductance as for particles in non-interacting systems.
doi: 10.1038/nature22052
Combining the benefits of nanocrystals with those of amorphous metallic glasses leads to a dual-phase material—comprising sub-10-nanometre-sized nanocrystalline grains embedded in amorphous glassy shells—that exhibits a strength approaching the ideal theoretical limit.
doi: 10.1038/nature21691
A nickel catalyst that promotes carboxylation of halogenated hydrocarbons at remote aliphatic sites with carbon dioxide via tunable and controllable chain-walking is described.
doi: 10.1038/nature22316
Tokummia katalepsis from the Burgess Shale had a pair of mandibles and maxilliped claws, showing that large bivalved arthropods from the Cambrian period are forerunners of myriapods and pancrustaceans, thereby providing a basis for the origin of the hyperdiverse mandibulate body plan.
doi: 10.1038/nature22080
Conditional deletion of the mitochondrial Na+/Ca2+ exchanger NCLX in adult mouse hearts causes sudden death due to mitochondrial calcium overload, whereas its overexpression limits cell death elicited by ischaemia reperfusion injury and heart failure.
doi: 10.1038/nature22082
Interferon-γ acts on tumour endothelial cells to drive vascular regression, inducing ischaemia that leads to tumour collapse.
doi: 10.1038/nature22311
Under physiological forces, resulting from cytokinesis, the mechanosensitivity of adherens junction arises from a local decrease in E-cadherin concentration and results in actomyosin flows.
doi: 10.1038/nature22041
The polyglutamine domain in ataxin 3, which is expanded in spinocerebellar ataxia type 3, allows normal ataxin 3 to interact with and deubiquitinate beclin 1 and thereby to promote autophagy.
doi: 10.1038/nature22078
Crystal structures of protease-activated receptor 2 (PAR2) in complex with two different antagonist ligands and with a blocking antibody reveal binding sites that are distinct from those found on PAR1, offering new leads for structure-based drug design.
doi: 10.1038/nature22309