反ユダヤ主義が大学などで再び見られるようになっているが、これは許してはならないことだ。
Challenge anti-Semitism p.407
A wave of anti-Jewish prejudice is once again washing over schools and universities. There is no excuse not to call out this vile behaviour.
doi: 10.1038/d41586-018-04926-3
A wave of anti-Jewish prejudice is once again washing over schools and universities. There is no excuse not to call out this vile behaviour.
doi: 10.1038/d41586-018-04926-3
As officials meet in Bonn to swap stories on progress towards the Paris goals, only emissions cuts will guarantee a happy ending.
doi: 10.1038/d41586-018-04925-4
Results from a Nature photo competition show the power of images.
doi: 10.1038/d41586-018-04924-5
New climate-inequality tool quantifies how quickly the weather will veer beyond normal in different regions.
doi: 10.1038/d41586-018-04854-2
Young researchers who narrowly miss out on postdoctoral grant struggle to compete with those who just qualify.
doi: 10.1038/d41586-018-04958-9
Images from Landsat satellites and agricultural-survey programme are freely available to scientists — but for how long?
doi: 10.1038/d41586-018-04874-y
With a move from London to Amsterdam less than a year away, the European Medicines Agency is facing uncertainty.
doi: 10.1038/d41586-018-04917-4
Researchers hope European–Russian Trace Gas Orbiter will end a long-running debate over source of the gas on Mars.
doi: 10.1038/d41586-018-04948-x
Direct sequencing of RNA molecules such as virus genomes should help to unpick role of mysterious chemical modifications.
doi: 10.1038/d41586-018-04908-5
人間社会が化石燃料への依存を克服できる可能性は十分にあるが、そのために残された時間はわずかである。
doi: 10.1038/d41586-018-04931-6
アルツハイマー病などの神経変性疾患の原因が、脳の免疫系による「誤爆」によって引き起こされる炎症にある可能性が明らかになってきた。
doi: 10.1038/d41586-018-04930-7
今回、平面状の反応中間体の1つの面だけのトポロジーを認識する触媒が開発された。注目すべきは、これによって反応生成物の鏡像異性体の片方だけを選択的に生成できるようになったことである。
doi: 10.1038/d41586-018-04684-2
出生前後にHIVに感染した青年の疫学研究によって、全てのHIV感染小児の治療を出生後数年以内に開始できることが高所得国にどのような恩恵をもたらしているかが明らかになった。
doi: 10.1038/d41586-018-04476-8
ブラインシュリンプの移動が、水柱をかなり混合していることが、今回分かった。
doi: 10.1038/d41586-018-04673-5
がんの単一細胞解析は、個々の細胞の生物量が少ないため限界がある。今回、単一の腫瘍由来細胞から3Dオルガノイド構造体をin vitroで作ることで、詳細に解析するのに十分な生物量が得られた。
doi: 10.1038/d41586-018-03841-x
上皮細胞由来のがんには、間葉細胞の形質を獲得した数種の腫瘍細胞が含まれていることが多い。今回、このことががんの転移につながる仕組みがマウスモデルで明らかになった。
doi: 10.1038/d41586-018-04403-x
今回2つの実験によって、無数の原子からなる遠く離れた機械系の間のエンタングルメント(非古典的相関)が実証された。この結果によって、量子物理学の理解が前進すると思われる。
doi: 10.1038/d41586-018-04827-5
今回、ある神経集団が、飢えと痛みという競合する要求を調節していることが分かった。切迫した痛みは飢えに優先するが、食欲によって生じる神経活動によって長期にわたる疼痛応答が低下し、摂食が可能になるのである。
doi: 10.1038/d41586-018-04759-0
The unimolecular nucleophilic substitution (S
doi: 10.1038/s41586-018-0042-1
A new version of the phylogenetic bootstrap method enables assessment of the robustness of phylogenies that are based on large datasets of hundreds or thousands of taxa.
doi: 10.1038/s41586-018-0043-0
Organoids derived from individual cells from colorectal cancers and adjacent normal tissue are used to investigate intra-tumour diversification at the genomic, epigenetic and functional levels.
doi: 10.1038/s41586-018-0024-3
Epithelial-to-mesenchymal transition in tumour cells occurs through distinct intermediate states, associated with different metastatic potential, cellular properties, gene expression, and chromatin landscape
doi: 10.1038/s41586-018-0040-3
Observations of carbon monoxide and ionized carbon lines from the source SPT2349-56 show it to contain a cluster of at least fourteen gas-rich galaxies with redshifts of 4.31, in a highly dense core region.
doi: 10.1038/s41586-018-0025-2
Remote quantum entanglement is demonstrated in a micromachined solid-state system comprising two optomechanical oscillators across two chips physically separated by 20 cm and with an optical separation of around 70 m.
doi: 10.1038/s41586-018-0036-z
Quantum entanglement is demonstrated in a system of massive micromechanical oscillators coupled to a microwave-frequency electromagnetic cavity by driving the devices into a steady state that is entangled.
doi: 10.1038/s41586-018-0038-x
Ohmic losses in plasmonic devices can be reduced by exploiting ‘resonant switching’, in which light couples to surface plasmon polaritons only when in resonance and bypasses them otherwise.
doi: 10.1038/s41586-018-0031-4
During continent collision and associated mountain building, a surprisingly large volume of the lower crust is shown to be affected by earthquake aftershocks, producing a top-down effect on crustal geodynamics.
doi: 10.1038/s41586-018-0045-y
Acute heat stress from the extended marine heatwave of 2016 is a potent driver of the transformation of coral assemblages, which affects even the most remote and well-protected reefs of the Great Barrier Reef.
doi: 10.1038/s41586-018-0041-2
Laboratory experiments with the brine shrimp Artemia salina illustrate the potential for turbulence generated by the diurnal vertical migrations of aggregations of centimetre-scale zooplankton to affect the physical and biogeochemical structure of oceanic water columns.
doi: 10.1038/s41586-018-0044-z
Metabolic regulation has been recognized as a powerful principle guiding immune responses. Inflammatory macrophages undergo extensive metabolic rewiring1 marked by the production of substantial amounts of itaconate, which has recently been described as an immunoregulatory metabolite2. Itaconate and its membranepermeable derivative dimethyl itaconate (DI) selectively inhibit a subset of cytokines2, including IL-6 and IL-12 but not TNF. The major effects of itaconate on cellular metabolism during macrophage activation have been attributed to the inhibition of succinate dehydrogenase2,3, yet this inhibition alone is not sufficient to account for the pronounced immunoregulatory effects observed in the case of DI. Furthermore, the regulatory pathway responsible for such selective effects of itaconate and DI on the inflammatory program has not been defined. Here we show that itaconate and DI induce electrophilic stress, react with glutathione and subsequently induce both Nrf2 (also known as NFitalicL2)-dependent and -independent responses. We find that electrophilic stress can selectively regulate secondary, but not primary, transcriptional responses to toll-like receptor stimulation via inhibition of IκBζ protein induction. The regulation of IκBζ is independent of Nrf2, and we identify ATF3 as its key mediator. The inhibitory effect is conserved across species and cell types, and the in vivo administration of DI can ameliorate IL-17–IκBζ- driven skin pathology in a mouse model of psoriasis, highlighting the therapeutic potential of this regulatory pathway. Our results demonstrate that targeting the DI–IκBζ regulatory axis could be an important new strategy for the treatment of IL-17–IκBζ-mediated autoimmune diseases.
doi: 10.1038/s41586-018-0052-z
A subset of neurons in the hypothalamus is identified as the primary site of action for regulating energy balance and glucose homeostasis by leptin.
doi: 10.1038/s41586-018-0049-7
Binding of an ES cell-specific transcription factor pre-marks cell-type-restricted enhancers in ES cells, and this premarking is required for the robustness of enhancer activation in differentiated cells.
doi: 10.1038/s41586-018-0048-8
A high-resolution X-ray structure and molecular dynamics simulations of the N-methyl-d-aspartate receptor in complexes with channel-blocking ligands reveals the molecular basis of the ligand binding and channel block.
doi: 10.1038/s41586-018-0039-9
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology1,2. The NPY–Y receptor system has emerged as one of the most complex networks with three peptide ligands (NPY, peptide YY and pancreatic polypeptide) binding to four receptors in most mammals, namely the Y
doi: 10.1038/s41586-018-0046-x