Volume 546 Number 7659


Don’t let Europe’s open-science dream drift p.451

Now that the major players have agreed to the giant European Open Science Cloud, it’s time to get the project moving.

doi: 10.1038/546451a

Protect funding for US earthquake early-warning system p.451

Donald Trump’s proposed cuts to ShakeAlert puts the west coast at risk.

doi: 10.1038/nature.2017.22162

Heatwaves to soar above the hot air of climate politics p.452

Future generations will fear, rather than fend for, the global environment.

doi: 10.1038/546452a


Macron consolidates electoral victory p.459

The party of France’s recently elected president won an absolute majority in its first general elections, with an agenda that included strong support for research.

doi: 10.1038/549459a

Ancient oak's youthful genome surprises biologists p.460

DNA of 234-year-old tree has few mutations, giving weight to idea that plants protect their stem cells.

doi: 10.1038/546460a

China’s genomics giant to make stock-market debut p.461

Once the world's biggest DNA sequencer for research, BGI is now looking to medical applications to boost profits.

doi: 10.1038/546461

Teeth tell tale of hippo’s quick spread across Africa p.462

Fossils from ancient hippo ancestor suggest that grass helped the animals to conquer a continent.

doi: 10.1038/nature.2017.22168

New concerns raised over value of genome-wide disease studies p.463

Large analyses dredge up 'peripheral' genetic associations that offer little biological insight, researchers say.

doi: 10.1038/nature.2017.22152

China cracks down on fake peer reviews p.464

Funding agencies announce harsh penalties and stronger policing efforts.

doi: 10.1038/546464a

News Features

The fight to save thousands of lives with sea-floor sensors p.466

Geophysicists are racing to monitor underwater faults in Earth’s crust so they can provide warning of the next big earthquake and tsunami.

doi: 10.1038/546466a

News & Views

Vision: These retinas are made for walkin' p.476

Measurements of the activity of neurons called direction-selective ganglion cells in the mouse retina explain how visual motion encoded by the eye maps onto body movements such as walking. See Article p.492

doi: 10.1038/nature22505

Particle physics: No sign of asymmetry in the strong force p.477

The strong force binds the constituents of nuclei together. Differences between the force's fundamental interactions and their mirror images were thought to have been observed in heavy-ion collisions, but new data challenge this picture.

doi: 10.1038/nature23086

Bacterial pathogens: A spoonful of sugar could be the medicine p.479

Pili are filamentous bacterial structures that promote adhesion to host cells. It emerges that a small molecule that inhibits this adhesion can prevent colonization of the mouse gut by a pathogenic bacterium. See Letter p.528

doi: 10.1038/nature23084

Genomics: The feline line p.480

doi: 10.1038/546480a

Quantum physics: Interactions propel a magnetic dance p.481

A combination of leading-edge techniques has enabled interaction-induced magnetic motion to be observed for pairs of ultracold atoms — a breakthrough in the development of models of complex quantum behaviour. See Letter p.519

doi: 10.1038/546481a

Neuroinflammation: Synapses pruned in lupus p.482

Lupus is an autoimmune disease that can cause brain dysfunction. Studies in mouse models of lupus find that interferon proteins can cause the brain's immune cells to trim the synaptic connections between neurons. See Letter p.539

doi: 10.1038/nature23087

Climate science: Clouds unfazed by haze p.483

The extent to which aerosols affect climate is highly uncertain. Observations of clouds interacting with aerosols from a volcanic eruption suggest that the effect is much smaller than was once feared. See Article p.485

doi: 10.1038/546483a


Strong constraints on aerosol–cloud interactions from volcanic eruptions p.485

Investigations of an Icelandic volcanic eruption confirm that sulfate aerosols caused a discernible yet transient brightening effect, as predicted, but their effect on the liquid water path was unexpectedly negligible.

doi: 10.1038/nature22974

A retinal code for motion along the gravitational and body axes p.492

Global mapping shows that mouse retinal neurons prefer visual motion produced when the animal moves along two behaviourally relevant axes, allowing the encoding of the animal’s every translation and rotation.

doi: 10.1038/nature22818

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer p.498

Exosomes improve the delivery of siRNA to mutant KRAS in the pancreatic tumours and bypass immune clearance better than artificial liposomes, probably owing to enhanced macropinocytocis and presence of CD47 on exosomes, respectively.

doi: 10.1038/nature22341

Structure of the human multidrug transporter ABCG2 p.504

The structure of human ABCG2 bound to an inhibitory antibody using cryo-electron microscopy, representing the first high-resolution structural data of a human multidrug transporter.

doi: 10.1038/nature22345


A massive, dead disk galaxy in the early Universe p.510

When the Universe was just 3 billion years old, half of the most massive galaxies had already ceased star formation, and such a galaxy has now been observed using gravitational lensing, unexpectedly turning out to be a compact, fast-spinning disk galaxy rather than a proto-bulge galaxy.

doi: 10.1038/nature22388

A giant planet undergoing extreme-ultraviolet irradiation by its hot massive-star host p.514

The giant planet KELT-9b has a dayside temperature of about 4,600 K, which is sufficiently high to dissociate molecules and to evaporate its atmosphere, owing to its hot stellar host.

doi: 10.1038/nature22392

Microscopy of the interacting Harper–Hofstadter model in the two-body limit p.519

The combination of interparticle interactions and a synthetic gauge field leads to chirality in the propagation dynamics of particles in a ladder-like lattice.

doi: 10.1038/nature22811

Improved maize reference genome with single-molecule technologies OPEN p.524

An improved reference genome for maize, using single-molecule sequencing and high-resolution optical mapping, enables characterization of structural variation and repetitive regions, and identifies lineage expansions of transposable elements that are unique to maize.

doi: 10.1038/nature22971

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist p.528

Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously treating urinary tract infections without disrupting the composition of the gut microbiota.

doi: 10.1038/nature22972

Multilineage communication regulates human liver bud development from pluripotency p.533

Single-cell RNA sequencing analysis of two- and three-dimensional hepatic differentiation reveals that both systems recapitulate certain transcriptomic features of human hepatogenesis.

doi: 10.1038/nature22796

Microglia-dependent synapse loss in type I interferon-mediated lupus p.539

Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.

doi: 10.1038/nature22821

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge p.544

Histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude.

doi: 10.1038/nature22819

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation p.549

BRCA1-associated protein 1 (BAP1) regulates calcium flux in the endoplasmic reticulum to facilitate the execution of apoptosis, unveiling a new facet of the role of BAP1 as an environmental tumour suppressor.

doi: 10.1038/nature22798

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth p.554

PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the endoplasmic reticulum to mitochondria and inducing apoptosis; inhibiting FXBL2 sensitizes PTEN-deficient tumours to photodynamic therapy.

doi: 10.1038/nature22965

Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage p.559

The structure of Cpf1, a CRISPR–Cas/RNA-guided nuclease, is presented with a three-stranded RNA–DNA loop after cleavage, providing insight into its working mechanism.

doi: 10.1038/nature22398

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