Biohackers can boost trust in biology p.291

DIY scientists in Germany can bring techniques out of the lab and help the country learn to love the field.

doi: 10.1038/d41586-017-08807-z

Full Text


Extreme weather explicitly blamed on humans for the first time p.291

Scientists take the bold step of saying phenomena wouldn’t have happened without global warming.

doi: 10.1038/d41586-017-08808-y

Full Text


Interstellar message of ‘Oumuamua p.292

Mysterious traveller from afar highlights a seasonal greeting.

doi: 10.1038/d41586-017-08809-x

Full Text



Rescued radar maps reveal Antarctica's past p.299

More than 2 million newly digitized images extend the history of the bottom of the ice sheet.

doi: 10.1038/d41586-017-08329-8

Full Text


Gene editing staves off deafness in mice p.300

Technique to knock out mutant gene relies on fatty molecules to deliver CRISPR components to inner-ear cells.

doi: 10.1038/d41586-017-08722-3

Full Text


Could Bitcoin technology help science? p.301

Blockchain could lend security measures to the scientific process, but the approach has its own risks.

doi: 10.1038/d41586-017-08589-4

Full Text


South Korean scientists eager for reactor restart p.302

It’s good news for neutron scientists in the region.

doi: 10.1038/d41586-017-08476-y

Full Text


2017 in news: The science events that shaped the year p.304

A giant iceberg, a quantum-entanglement experiment and the death of a spacecraft are among the year’s top stories.

doi: 10.1038/d41586-017-08493-x

Full Text


2017 in pictures: The best science images of the year p.308

A spectacular total eclipse, hitch-hiking octopus, nanoscale fireworks and more.

doi: 10.1038/d41586-017-08492-y

Full Text

News Features


Nature's 10 p.315


doi: 10.1038/d41586-017-07763-y

Full Text

News & Views

微生物生態学: 大気の微量成分からエネルギーを得る

Microbial ecology: Energy from thin air p.336


doi: 10.1038/d41586-017-07579-w

Full Text

免疫学: 記憶T細胞の起源

Immunology: The origins of memory T cells p.337


doi: 10.1038/d41586-017-08280-8

Full Text

惑星科学: 地下に蓄えられている火星の水

Planetary science: Martian water stored underground p.339


doi: 10.1038/d41586-017-08670-y

Full Text

がん: 腫瘍のリンパ管が免疫療法の効果を高める

Cancer: Tumour lymph vessels boost immunotherapy p.340


doi: 10.1038/d41586-017-08669-5

Full Text

神経変性疾患: アルツハイマー病に関するスペックの知見

Neurodegenerative disorders: Specks of insight into Alzheimer’s disease p.342


doi: 10.1038/d41586-017-08668-6

Full Text


2017 in research: Choice cuts from this year’s News & Views articles p.344

今年度掲載されたNews & Viewsの中から編集部が精選した記事の抜粋。

doi: 10.1038/d41586-017-08516-7

Full Text


有機化学: 触媒的クロスメタセシスによるE型とZ型の三置換アルケンの合成

Synthesis of E- and Z-trisubstituted alkenes by catalytic cross-metathesis p.347

An approach for the synthesis of E- and Z- trisubstituted alkenes in high stereoisomeric purity is developed by merging catalytic cross-metathesis and cross-coupling processes.

doi: 10.1038/nature25002

日本語要約 | Full Text | PDF

神経変性疾患: ミクログリア由来のASCスペックはアルツハイマー病でアミロイドβをクロスシードする

Microglia-derived ASC specks crossseed amyloid-β in Alzheimer’s disease p.355

Deposition and spreading of amyloid-β pathology in mice requires binding to microglia-released ASC specks.

doi: 10.1038/nature25158

日本語要約 | Full Text | PDF

免疫学: ワクチン接種後のヒト記憶CD8 T細胞の起源と分化

Origin and differentiation of human memory CD8 T cells after vaccination p.362

In vivo deuterium labelling reveals a quiescent population of long-lived human virus-specific memory CD8 T cells that maintain the epigenetic landscape of effector cells, which facilitates rapid responses to pathogen re-exposure.

doi: 10.1038/nature24633

日本語要約 | Full Text | PDF

構造生物学: mTORC1のRHEBによる活性化とPRAS40による阻害の機構

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40 p.368

The cryo-electron microscopy and crystal structures of several mTORC1 complexes, and accompanying biochemical analyses, shed light on how mTORC1 is regulated and how cancer mutations lead to its hyperactivation.

doi: 10.1038/nature25023

日本語要約 | Full Text | PDF


天文学: ねじれた不均質なジェットによって説明されるブレーザーのスペクトル変動

Blazar spectral variability as explained by a twisted inhomogeneous jet p.374

The spectral variability of the blazar CTA 102 during a recent extreme outburst could be explained by a twisted, inhomogeneous jet containing regions of different orientations that vary in time.

doi: 10.1038/nature24623

日本語要約 | Full Text | PDF

天文学: 赤色の極端に細長い恒星間小惑星のつかの間の訪問

A brief visit from a red and extremely elongated interstellar asteroid p.378

The first interstellar object to be detected in the Solar System is asteroidal in nature and has a shape unlike any Solar System body, with a length about ten times its width.

doi: 10.1038/nature25020

日本語要約 | Full Text | PDF

磁気圏物理学: 地球近傍空間におけるアルベド中性子崩壊と中性子密度からの電子の測定

Measurement of electrons from albedo neutron decay and neutron density in near-Earth space p.382

Electrons derived from cosmic rays become trapped in the radiation belts that surround Earth, but how the electrons are generated has been uncertain; new measurements confirm the involvement of neutron decay.

doi: 10.1038/nature24642

日本語要約 | Full Text | PDF

素粒子物理学: 宇宙線ミューオンの観測によるクフ王のピラミッド内部における大空間の発見

Discovery of a big void in Khufu’s Pyramid by observation of cosmic-ray muons p.386

Cosmic-ray muon radiography has been used to non-invasively visualize the voids in the Great Pyramid (Khufu’s Pyramid), revealing a large void situated above the Grand Gallery.

doi: 10.1038/nature24647

日本語要約 | Full Text | PDF

惑星科学: 地球と火星の始原的水圏の水の異なる運命

The divergent fates of primitive hydrospheric water on Earth and Mars p.391

Modelling the reactions of water with the crusts of early Earth and Mars sheds light on how water was transported through their crusts to give the surfaces we see today.

doi: 10.1038/nature25031

日本語要約 | Full Text | PDF

古生物学: シンクロトロンによるスキャンで明らかになった、新たな鳥類様恐竜クレードの水陸両生性の生態形態

Synchrotron scanning reveals amphibious ecomorphology in a new clade of bird-like dinosaurs p.395

The recently discovered theropod Halszkaraptor escuillei reveals a novel basal dromaeosaurid clade, and its adaptations that suggest a semi-aquatic predatory lifestyle add an additional ecomorphology to those developed by non-avian maniraptorans.

doi: 10.1038/nature24679

日本語要約 | Full Text | PDF

微生物生態学: 南極砂漠では大気中の微量ガスが表面土壌の一次生産を支えている

Atmospheric trace gases support primary production in Antarctic desert surface soil p.400

Metagenomic and biochemical analyses of soil samples from Antarctic desert regions provides evidence that bacteria in these soils derive carbon and energy from atmospheric CO, H2 and CO2.

doi: 10.1038/nature25014

日本語要約 | Full Text | PDF

免疫学: エフェクターCD8 T細胞は長期生存記憶細胞へ脱分化する

Effector CD8 T cells dedifferentiate into long-lived memory cells p.404

DNA methylation profiling of virus-specific T cells during acute viral infection in mice provides evidence that a fate-permissive subset of effector CD8 T cells dedifferentiates into long-lived memory T cells.

doi: 10.1038/nature25144

日本語要約 | Full Text | PDF

細胞生物学: クラスリンを介したエンドサイトーシス輸送におけるホスホイノシチド変換の動態

Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic p.410

‘Coincidence-detecting’ phosphoinositide sensors are used to study changes in the phosphoinositide lipid species found in membranes during the development and maturation of endocytic clathrin-coated vesicles.

doi: 10.1038/nature25146

日本語要約 | Full Text | PDF

生物工学: 自身のRNAゲノムを封入するように設計されたタンパク質集合体の進化

Evolution of a designed protein assembly encapsulating its own RNA genome p.415

Computationally designed icosahedral protein-based assemblies can protect their genetic material and evolve in biochemical environments, suggesting a route to the custom design of synthetic nanomaterials for non-viral drug delivery.

doi: 10.1038/nature25157

日本語要約 | Full Text | PDF

構造生物学: カルシウム依存性塩素イオンチャネルTMEM16Aの、クライオ電子顕微鏡によって明らかになった活性化機構

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM p.421

Cryo-electron microscopy mapping of the calcium-activated chloride channel TMEM16A combined with functional experiments reveals that calcium ions interact directly with the pore to activate the channel.

doi: 10.1038/nature24652

日本語要約 | Full Text | PDF

構造生物学: カルシウム依存性塩素イオンチャネルTMEM16Aのクライオ電子顕微鏡構造

Cryo-EM structures of the TMEM16A calcium-activated chloride channel p.426

Electron cryo-microscopy density maps of mouse TMEM16A reconstituted in nanodiscs or solubilized in detergent reveal two functional states of calcium-activated chloride channels.

doi: 10.1038/nature25024

日本語要約 | Full Text | PDF

「Journal home」に戻る