The last known person to die from the virus was infected 40 years ago. Yet the disease remains a worry, and precautions should continue.
doi: 10.1038/d41586-018-05936-x
Health workers must figure out how to dispense vaccines amid fighting in the eastern Democratic Republic of the Congo.
doi: 10.1038/d41586-018-05921-4
Unpaywall has become indispensable to many academics, and tie-ins with established scientific search engines could broaden its reach.
doi: 10.1038/d41586-018-05968-3
The US Food and Drug Administration’s decision breathes new life into RNA-interference therapies.
doi: 10.1038/d41586-018-05867-7
Critics outraged over changes to chemical-safety review guidelines.
doi: 10.1038/d41586-018-05946-9
The world’s most powerful particle collider has yet to turn up new physics — now some physicists are turning to a different strategy.
doi: 10.1038/d41586-018-05972-7
実在する薬物の売人と使用者をモデル化したバーチャル都市のシミュレーションが、米国の深刻なオピオイド乱用の広がりを食い止める足掛かりになる可能性がある。
doi: 10.1038/d41586-018-05939-8
2つ1組で働く触媒が、同じ触媒を逐次的に用いた場合よりも効果的な反応を促進し得ることが、今回分かった。酵素と光活性化触媒の組み合わせから、有機合成に大きな可能性がもたらされた。
doi: 10.1038/d41586-018-05933-0
ヒトは、色を分類して知覚する。例えば、赤の色相は、ルビー色や深紅色などに識別できるにもかかわらず赤色に分類される。今回、鳥類も色を分類しており、これが鳥類の色弁別能力に影響を及ぼしていることが分かった。
doi: 10.1038/d41586-018-05811-9
今回、哺乳類の気管の単一細胞RNA塩基配列解読によって、体液平衡と溶質平衡に関わる遺伝子を発現していて嚢胞性線維症に関与している可能性のある、これまで知られていなかった気道細胞が明らかになった。
doi: 10.1038/d41586-018-05813-7
環化付加反応は、3D分子を合成する強力な手段であるが、適用できる範囲は限られている。今回、この問題の創造的解決策によって、創薬の機会が開かれた。
doi: 10.1038/d41586-018-05874-8
ニュートリノは、常にその種類を変える小さくて幽霊のような素粒子である。今回、地球を通り抜ける高エネルギーニュートリノが変化する速度が測定され、アインシュタインの特殊相対性理論がこれまでにない精度で検証された。
doi: 10.1038/d41586-018-05931-2
今回、ゲノム編集法を用いて、16本の酵母染色体を融合させ、染色体を1本あるいは2本しか持たない酵母株が作られた。意外なことに、こうした融合は細胞の健常性にほとんど影響を及ぼさなかった。
doi: 10.1038/d41586-018-05309-4
Single-cell RNA sequencing analysis identifies cell types and lineages in airway epithelium, including the pulmonary ionocyte, a new cell type predominantly expressing the cystic fibrosis gene
doi: 10.1038/s41586-018-0393-7
The extent, origins and consequences of genetic variation within human cell lines are studied, providing a framework for researchers to measure such variation in efforts to support maximally reproducible cancer research.
doi: 10.1038/s41586-018-0409-3
Successive fusion of yeast chromosomes is used to produce a single-chromosome strain that is viable, albeit with slightly reduced fitness.
doi: 10.1038/s41586-018-0382-x
Two- and three-layer WTe2 exhibits spontaneous out-of-plane electric polarization that can be switched electrically at room temperature and is sufficiently robust for use in applications with other two-dimensional materials.
doi: 10.1038/s41586-018-0336-3
Heterobilayer excitonic devices consisting of two different van der Waals materials, in which excitons are shared between the layers, exhibit electrically controlled switching actions at room temperature.
doi: 10.1038/s41586-018-0357-y
Direct observation of the anode–electrolyte interface in a lithium-metal battery, without removing the liquid electrolyte, reveals two types of dendrites, one of which may contribute disproportionately to capacity fade.
doi: 10.1038/s41586-018-0397-3
Combining cycloaddition and carbon–carbon cross-coupling offers a way of simplifying the enantioselective preparation of chemical building blocks, natural products and medicines such as the antipsychotic asenapine.
doi: 10.1038/s41586-018-0391-9
A cooperative chemoenzymatic reaction combines photocatalytic alkene isomerization with enzymatic reduction to generate enantioenriched products in a stereoconvergent manner.
doi: 10.1038/s41586-018-0413-7
Satellite observations and Earth system model simulations reveal that marine heatwaves have increased in recent decades and will increase further in terms of frequency, intensity, duration and spatial extent.
doi: 10.1038/s41586-018-0383-9
Female zebra finches exhibited categorical perception of colour signals, as they categorized colour stimuli that varied along a continuous scale and showed increased discrimination between colours from opposite sides of the category boundary compared to equally different colours from within a category.
doi: 10.1038/s41586-018-0377-7
Experimental whole-ecosystem warming treatments of a
doi: 10.1038/s41586-018-0399-1
Many small molecules that stimulate oligodendrocyte formation act not through their canonical pathways but by inhibiting enzymes within the cholesterol biosynthesis pathway and thereby inducing the accumulation of 8,9-unsaturated sterols.
doi: 10.1038/s41586-018-0360-3
Single-cell RNA sequencing analysis is used to identify cell types in the tracheal epithelium, including previously unidentified ionocytes, which express high levels of the cystic fibrosis transmembrane conductance regulator,
doi: 10.1038/s41586-018-0394-6
Melanoma cells release programmed death-ligand 1 (PD-L1) on the surface of circulating exosomes, suggesting a mechanism by which tumours could evade the immunesystem, and the potential application of exosomal PD-L1 to monitor patient response to checkpoint therapies.
doi: 10.1038/s41586-018-0392-8
A pro-survival multiprotein signalling supercomplex consisting of the B-cell receptor, MyD88, TLR9 and mTOR is discovered that coordinates NF-κB activation in diffuse large B cell lymphoma, and provides mechanistic insight into the efficacy of drug combinations.
doi: 10.1038/s41586-018-0290-0
Yeast chromosomes have been fused to produce viable strains with only two chromosomes that are reproductively isolated from the sixteen-chromosome wild type, but otherwise show high fitness in mitosis and meiosis.
doi: 10.1038/s41586-018-0374-x
During sexual reproduction in
doi: 10.1038/s41586-018-0407-5
