Volume 560 Number 7717


惑星状星雲HuBi 1の電離構造が「裏返し」になっていることが明らかになり、注目を浴びている。

A star that hides its shine draws admiring looks p.141

Astronomers find a planetary nebula with an unusual structure.

doi: 10.1038/d41586-018-05886-4


Signs of hope emerge against influenza p.141

A universal vaccine might be some way off, but research into how the immune system responds to the virus will be crucial to achieving that goal.

doi: 10.1038/d41586-018-05885-5



Indian scientists race to map Ganges river in 3D p.149

Digital models of the river and surrounding settlements will help authorities to track and reduce waste.

doi: 10.1038/d41586-018-05872-w

米国トランプ大統領が、就任から19か月を経てようやく、気象学者のKelvin Droegemeierを科学顧問に指名。

The wait is over: Trump taps meteorologist as White House science adviser p.150

Nomination of Kelvin Droegemeier could end long drought at the White House Office of Science and Technology Policy.

doi: 10.1038/d41586-018-05862-y


Thousands of exotic ‘topological’ materials discovered through sweeping search p.151

Haul thrills physicists, who previously knew of just a few hundred of these peculiar materials.

doi: 10.1038/d41586-018-05913-4


Number-theory prodigy among winners of most coveted prize in mathematics p.152

The Fields Medals have been awarded to four researchers who work on number theory, geometry and differential equations.

doi: 10.1038/d41586-018-05864-w


Gigantic review of German science recommends more data and diversity p.153

Big data and diversity lacking at Germany’s biggest science organization.

doi: 10.1038/d41586-018-05818-2

News Features


The mice with human tumours: Growing pains for a popular cancer model p.156


doi: 10.1038/d41586-018-05890-8


The ghost of influenza past and the hunt for a universal vaccine p.158


doi: 10.1038/d41586-018-05889-1

News & Views


Engineering: Integration of optoelectronics into fibres enhances textiles p.170


doi: 10.1038/d41586-018-05873-9


Parasitology: Drug candidate and target for leishmaniasis p.171


doi: 10.1038/d41586-018-05765-y


Alzheimer’s disease: A lymphatic waste-disposal system implicated in Alzheimer’s disease p.172


doi: 10.1038/d41586-018-05763-0


Condensed-matter physics: Stable and switchable electric polarization in two dimensions p.174


doi: 10.1038/d41586-018-05807-5


Materials science: Topological states engineered in narrow strips of graphene p.175


doi: 10.1038/d41586-018-05851-1


Immunology: Newly made mitochondrial DNA drives inflammation p.176


doi: 10.1038/d41586-018-05764-z



Coherent spin–photon coupling using a resonant exchange qubit p.179

Coherent coupling between a three-electron spin qubit and single photons in a microwave resonator is demonstrated, which, unlike previous demonstrations, does not require ferromagnetic components near the qubit.

doi: 10.1038/s41586-018-0365-y


Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease p.185

Meningeal lymphatic dysfunction promotes amyloid-β deposition in the meninges and worsens brain amyloid-β pathology, acting as an aggravating factor in Alzheimer’s disease and in age-associated cognitive decline; improving meningeal lymphatic function could help to prevent or delay age-associated neurological diseases.

doi: 10.1038/s41586-018-0368-8


Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis p.192

A series of compounds are discovered for the treatment of visceral leishmaniasis, and cdc2-related kinase 12 (CRK12) is identified as the probable primary drug target.

doi: 10.1038/s41586-018-0356-z


New mitochondrial DNA synthesis enables NLRP3 inflammasome activation p.198

New mitochondrial DNA synthesis links the priming and activation of the NLRP3 inflammasome.

doi: 10.1038/s41586-018-0372-z



Topological band engineering of graphene nanoribbons p.204

A topologically engineered graphene nanoribbon superlattice is presented that hosts a one-dimensional array of half-filled, in-gap localized electronic states, enabling band engineering.

doi: 10.1038/s41586-018-0376-8


Engineering of robust topological quantum phases in graphene nanoribbons p.209

Graphene nanoribbons are used to design robust nanomaterials with controlled periodic coupling of topological boundary states to create quasi-one-dimensional trivial and non-trivial electronic quantum phases.

doi: 10.1038/s41586-018-0375-9


Diode fibres for fabric-based optical communications p.214

A scalable thermal drawing process is used to integrate light-emitting and photodetecting diodes into textile-ready polymer fibres, which can be woven into fabrics with possible optical communication and health monitoring applications.

doi: 10.1038/s41586-018-0390-x


Extensive loss of past permafrost carbon but a net accumulation into present-day soils p.219

Comparing the northern permafrost region of the Last Glacial Maximum with the same area today shows that the soil carbon stock has now increased, suggesting that permafrost carbon made no net contribution to preindustrial atmospheric carbon.

doi: 10.1038/s41586-018-0371-0


Xenon isotopic constraints on the history of volatile recycling into the mantle p.223

Mantle xenon isotope systematics reveals that no substantial recycling of atmospheric xenon into the deep Earth occurred before 2.5 billion years ago, indicating that downwellings were drier in the Archaean era than today.

doi: 10.1038/s41586-018-0388-4


Shared evolutionary origin of vertebrate neural crest and cranial placodes p.228

Similarities between the patterning of the lateral plate in Ciona and of the neural plate ectoderm in vertebrates indicate that compartmentalization of the lateral plate ectoderm preceded the advent of vertebrates.

doi: 10.1038/s41586-018-0385-7


Structure and function of the global topsoil microbiome p.233

Metagenomic, chemical and biomass analyses of topsoil samples from around the world reveal spatial and environmental trends in microbial community composition and genetic diversity.

doi: 10.1038/s41586-018-0386-6


Mitochondrial double-stranded RNA triggers antiviral signalling in humans p.238

Mitochondrial double-stranded RNA can induce an interferon response if released into the cytoplasm, but self-recognition is prevented by SUV3 helicase and PNPase exoribonuclease.

doi: 10.1038/s41586-018-0363-0


Human glioblastoma arises from subventricular zone cells with low-level driver mutations p.243

Human neural stem cells from the subventricular zone are identified as the cells of origin that contain the driver mutations for glioblastomas.

doi: 10.1038/s41586-018-0389-3


CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window p.248

A system that targets DNA polymerase activity with CRISPR-guided nickases to provide genetic diversification at user-defined loci enables forward genetic approaches.

doi: 10.1038/s41586-018-0384-8


Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth p.253

Selective inhibitors of KAT6A and KAT6B inhibit MYST-catalysed histone acetylation, induce cell cycle exit and cellular senescence without causing DNA damage, and arrest lymphoma progression in mouse models.

doi: 10.1038/s41586-018-0387-5


Cryo-EM of the dynamin polymer assembled on lipid membrane p.258

A cryo-electron microscopy structure of human dynamin-1 demonstrates conformational changes and sheds light on the fission of membranes during endocytosis.

doi: 10.1038/s41586-018-0378-6


Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM p.263

A cryo-electron microscopy structure of the mammalian mitochondrial translation initiation complex reveals unique features that are necessary to initiate mitochondrial translation and highlights a possible membrane-targeting peptide.

doi: 10.1038/s41586-018-0373-y

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