Worrying changes in Hungary p.485

The European country’s autocratic government has made a disturbing grab at the nation’s scientific institutions.

doi: 10.1038/d41586-018-05526-x


Five centres of Asian research show the benefit of local science p.485

Researchers in some Asian economies are working to address the distinct needs of their communities.

doi: 10.1038/d41586-018-05524-z

今週号を最後にNatureのEditor in Chiefを退くPhilip Campbellからのメッセージ。

Nature editor bids farewell p.486

A reflection as the seventh editor-in-chief of Nature hands over to the eighth.

doi: 10.1038/d41586-018-05525-y



Mysteries of Indian monsoon probed in Bay of Bengal p.493

A hurricane-hunter plane and research ships aim to gather the most-detailed observations yet of ‘intraseasonal’ variations in rainfall.

doi: 10.1038/d41586-018-05492-4


US–Chinese trade war puts scientists in the cross hairs p.494

Trump puts tariffs on Chinese technology and China retaliates with taxes on US chemicals.

doi: 10.1038/d41586-018-05521-2


Daring Japanese mission reaches unexplored asteroid Ryugu p.495

Hayabusa-2 will hover above its target and release four landing probes before touching down to collect samples to return to Earth.

doi: 10.1038/d41586-018-05544-9


Methane leaks from US gas fields dwarf government estimates p.496

Latest study suggests that emissions of the potent greenhouse gas could be coming from faulty equipment.

doi: 10.1038/d41586-018-05517-y


Genetically modified bacteria enlisted in fight against disease p.497

Engineered strains of E. coli and other microbes are being tested in people to combat a slew of illnesses.

doi: 10.1038/d41586-018-05476-4

News Features


Five hubs of Asian science p.499


doi: 10.1038/d41586-018-05504-3


Science in East Asia — by the numbers p.500


doi: 10.1038/d41586-018-05505-2


Science stars of East Asia p.502


doi: 10.1038/d41586-018-05506-1

News & Views


Planetary science: Mars beat Earth in the race for habitable conditions p.522


doi: 10.1038/d41586-018-05496-0


Medical research: Lessons for cancer drug treatment from tackling a non-cancerous overgrowth syndrome p.523


doi: 10.1038/d41586-018-05365-w


Quantum nanoscience: Upstanding molecule reveals orbital wavefunction p.525


doi: 10.1038/d41586-018-05502-5


Medical research: Weighing in on weight loss in pancreatic cancer p.526


doi: 10.1038/d41586-018-05424-2


In retrospect: Twenty years of network science p.528


doi: 10.1038/d41586-018-05444-y


Structural biology: How the ubiquitous GPCR receptor family selectively activates signalling pathways p.529


doi: 10.1038/d41586-018-05503-4



Triggers of tree mortality under drought p.531

Because climate change is expected to intensify regional-scale droughts, it is important to identify the physiological thresholds that precipitate the mortality of trees and the mechanisms of recovery after drought.

doi: 10.1038/s41586-018-0240-x



Targeted therapy in patients with PIK3CA-related overgrowth syndrome p.540

A PI3KCA inhibitor reverses symptoms in a mouse model of PROS/CLOVES syndrome, which results from gain-of-function mutations in PI3KCA, and produces improvements in patients with PROS/CLOVES syndrome.

doi: 10.1038/s41586-018-0217-9


Structure of the µ-opioid receptor–Gi protein complex p.547

A cryo-electron structure of the µ-opioid receptor in complex with the peptide agonist DAMGO and the inhibitory G protein Gi reveals structural determinants of its G protein-binding specificity.

doi: 10.1038/s41586-018-0219-7


Cryo-EM structure of human rhodopsin bound to an inhibitory G protein p.553

The cryo-electron microscopy structure of human rhodopsin bound to the inhibitory Gi protein-coupled receptor provides insights into ligand–receptor–G-protein interactions.

doi: 10.1038/s41586-018-0215-y


Structure of the adenosine-bound human adenosine A1 receptor–Gi complex p.559

The cryo-electron microscopy structure of the human adenosine A1 receptor in complex with adenosine and heterotrimeric Gi2 protein provides molecular insights into receptor and G-protein selectivity.

doi: 10.1038/s41586-018-0236-6



Macromolecular organic compounds from the depths of Enceladus p.564

The detection of complex organic molecules with masses higher than 200 atomic mass units in ice grains emitted from Enceladus indicates the presence of a thin organic-rich layer on top of the moon’s subsurface ocean.

doi: 10.1038/s41586-018-0246-4


Flying couplers above spinning resonators generate irreversible refraction p.569

One-way propagation of light through a standard telecommunications fibre is demonstrated by coupling the fibre to a rapidly rotating silica-glass sphere.

doi: 10.1038/s41586-018-0245-5


A standing molecule as a single-electron field emitter p.573

Precision control over matter at the atomic scale enables a planar dye molecule to be lifted up and placed on its edge—a configuration that is surprisingly stable.

doi: 10.1038/s41586-018-0223-y


Self-assembly of highly symmetrical, ultrasmall inorganic cages directed by surfactant micelles p.577

Machine-learning algorithms are used to generate single-particle three-dimensional reconstructions, revealing that highly symmetrical dodecahedral silica cages, around 10 nm in size, self-assemble in the presence of surfactant micelles.

doi: 10.1038/s41586-018-0221-0


Enantioselective remote meta-C–H arylation and alkylation via a chiral transient mediator p.581

Remote, enantioselective C–H activation reactions can be achieved by relaying ortho-C–H activation to the meta position, using a chiral norbornene as the mediator.

doi: 10.1038/s41586-018-0220-1


Evidence for extremely rapid magma ocean crystallization and crust formation on Mars p.586

Isotopic compositions of ancient zircons from the NWA 7034 Martian meteorite suggest that Mars must have formed its primordial crust extremely swiftly, less than 20 million years after the formation of the Solar System.

doi: 10.1038/s41586-018-0222-z


A synaptic threshold mechanism for computing escape decisions p.590

In the midbrain defensive circuit, the decision to escape is computed by an unreliable synaptic connection that thresholds threat information integrated in the medial superior colliculus, and controls activation of dorsal periaqueductal grey neurons.

doi: 10.1038/s41586-018-0244-6


A distinct abundant group of microbial rhodopsins discovered using functional metagenomics p.595

An analysis based on functional metagenomics reveals a previously unknown group of microbial light-sensory rhodopsins that are widespread among a diverse range of microorganisms.

doi: 10.1038/s41586-018-0225-9


Altered exocrine function can drive adipose wasting in early pancreatic cancer p.600

Pancreatic ductal adenocarcinoma in mice induces loss of adipose tissue through altered function of the exocrine pancreas, and supplementing pancreatic enzymes attenuates the wasting of peripheral tissues induced by pancreatic cancer.

doi: 10.1038/s41586-018-0235-7


Codon-specific translation reprogramming promotes resistance to targeted therapy p.605

Enzymes that catalyse modifications of wobble uridine 34 tRNA are essential for the survival of melanoma cells that rely on HIF1α-dependent metabolism through codon-dependent regulation of the translation of HIF1A mRNA.

doi: 10.1038/s41586-018-0243-7


A naturally occurring antiviral ribonucleotide encoded by the human genome p.610

Viperin inhibits the replication of various viruses by catalysing the conversion of CTP to ddhCTP, which is a unique nucleotide that functions as replication-chain terminator of RNA-dependent RNA polymerases.

doi: 10.1038/s41586-018-0238-4


Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation p.615

In Schizosaccharomyces pombe, histone H3K9 methylation acts synergistically with short interfering RNA to perpetuate gene silencing during multiple mitotic and meiotic cell divisions.

doi: 10.1038/s41586-018-0239-3


Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go p.620

The high-resolution structure of the serotonin 5-HT1B receptor in complex with the agonist donitriptan and a Go heterotrimer highlights features that may underly the specificity of receptor–G-protein coupling and kinetics of signalling.

doi: 10.1038/s41586-018-0241-9

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