Volume 559 Number 7712



Brain-protein structure could point way to safer prescription drugs p.5

Accidental overdoses from combinations of painkillers and tranquillizers highlight the importance of understanding fundamental biology.

doi: 10.1038/d41586-018-05578-z


Science must help to make city living sustainable p.5

It’s time researchers got to grips with the formidable challenge of rapidly growing urbanization.

doi: 10.1038/d41586-018-05605-z

今週号よりNatureのEditor in Chiefに就くMagdalena Skipperからのメッセージ。

A welcome from the new Nature editor p.6

Magdalena Skipper explains what readers can expect from the journal under her stewardship.

doi: 10.1038/d41586-018-05606-y



Gigantic study of Chinese babies yields slew of health data p.13

Early results from birth-cohort have public-health implications, as other groups use the data to investigate the microbiome and mental health.

doi: 10.1038/d41586-018-05522-1


There’s no limit to longevity, says study that revives human lifespan debate p.14

Death rates in later life flatten out and suggest there may be no fixed limit on human longevity, countering some previous work.

doi: 10.1038/d41586-018-05582-3


Cyprus asserts itself as regional hub for climate-change research p.15

Proposed science institute will focus on the Mediterranean and Middle East, regions that will be hard hit by global warming.

doi: 10.1038/d41586-018-05528-9


Delays mount for NASA’s $8-billion Hubble successor p.16

The James Webb Space Telescope won't launch until 2021 — and threatens to crowd out other big astronomy missions.

doi: 10.1038/d41586-018-05567-2


Europe’s biggest research fund cracks down on ‘ethics dumping’ p.17

The practice of conducting ethically dubious research in foreign countries is under fresh scrutiny.

doi: 10.1038/d41586-018-05616-w

News Features


The labs growing human embryos for longer than ever before p.19


doi: 10.1038/d41586-018-05586-z

News & Views


Earth science: Doubt cast on how the pace of global glacial erosion responds to climate cooling p.34


doi: 10.1038/d41586-018-05563-6


Cell biology: Actin proteins assemble to protect the genome p.35


doi: 10.1038/d41586-018-05339-y


Structural biology: Key receptor involved in neuronal signalling visualized p.37


doi: 10.1038/d41586-018-05538-7


Neuroscience: A molecular signature for social isolation identified in the brain p.38


doi: 10.1038/d41586-018-05447-9


Astronomy: General relativity verified by a triple-star system p.40


doi: 10.1038/d41586-018-05549-4


Developmental biology: Unexpected cell population gives fat a brake p.41


doi: 10.1038/d41586-018-05120-1


Tissue engineering: Taking bioengineered heart valves from faulty to functional p.42


doi: 10.1038/d41586-018-05566-3



Structural insights into G-protein-coupled receptor allostery p.45

High-resolution structural studies of GPCRs have led to insights into the role of allostery in GPCR-mediated signal transduction.

doi: 10.1038/s41586-018-0259-z



Nuclear F-actin and myosins drive relocalization of heterochromatic breaks p.54

Relocalization of heterochromatic double-strand breaks to the nuclear periphery in Drosophila cells occurs via directed motions driven by nuclear actin filaments and myosins activated by the Smc5/6 complex.

doi: 10.1038/s41586-018-0242-8


Nuclear ARP2/3 drives DNA break clustering for homology-directed repair p.61

Polymerization of actin in the cell nucleus, promoted by the ARP2/3 complex, drives the clustering of double-strand DNA breaks into nuclear compartments where they can undergo homology-directed repair.

doi: 10.1038/s41586-018-0237-5


Structure of a human synaptic GABAA receptor p.67

The cryo-electron microscopy structure of the type A GABA receptor bound to GABA and the benzodiazepine site antagonist flumazenil reveals structural mechanisms that underlie intersubunit interactions and ligand selectivity of the receptor.

doi: 10.1038/s41586-018-0255-3



Universality of free fall from the orbital motion of a pulsar in a stellar triple system p.73

The accelerations of a pulsar and a white dwarf in a three-star system differ by at most a few parts per million, providing a much improved constraint on the universality of free fall.

doi: 10.1038/s41586-018-0265-1


Multifunctional ferrofluid-infused surfaces with reconfigurable multiscale topography p.77

By infusing a ferrofluid into a microstructured matrix and applying a magnetic field, dynamic, multiscale topographical reconfigurations emerge, enabling functions such as colloidal self-assembly, switchable adhesion and friction, and biofilm removal.

doi: 10.1038/s41586-018-0250-8

化学:銅触媒と光レドックス触媒を用いる二重触媒作用による脱炭酸的sp3 C–Nカップリング

Decarboxylative sp3 C–N coupling via dual copper and photoredox catalysis p.83

The synergistic combination of copper catalysis and photoredox catalysis forms sp3 C–N bonds in a rapid, room-temperature coupling protocol with high efficiencies and regioselectivities and a broad substrate scope.

doi: 10.1038/s41586-018-0234-8


Spatial correlation bias in late-Cenozoic erosion histories derived from thermochronology p.89

Reported acceleration of erosion in mountainous landscapes during the late Cenozoic is the result of combining thermochronology data with disparate exhumation histories, thereby converting spatial variations in erosion rates into temporal increases.

doi: 10.1038/s41586-018-0260-6


Low-temperature crystallization of granites and the implications for crustal magmatism p.94

Thermobarometry and diffusion modelling in quartz crystals show that some granites may crystallize at much lower temperatures than we had thought, possibly explaining observations of cold magma storage.

doi: 10.1038/s41586-018-0264-2


Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus p.98

Adult neurogenesis in the hippocampus confers resilience to chronic stress in mice by inhibiting the activity of mature granule cells in the ventral dentate gyrus.

doi: 10.1038/s41586-018-0262-4


A stromal cell population that inhibits adipogenesis in mammalian fat depots p.103

Single-cell transcriptomics reveals that, in mice and humans, a population of cells in the stromal vascular fraction of adipose tissue regulates adipogenesis by suppressing adipocyte formation in a paracrine manner.

doi: 10.1038/s41586-018-0226-8


Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche p.109

Larvae of the parasitic helminth Heligmosomoides polygyrus induce granuloma formation and a fetal-like developmental program in granuloma-associated crypts of infected adult mice.

doi: 10.1038/s41586-018-0257-1


Induction of innate immune memory via microRNA targeting of chromatin remodelling factors p.114

The microRNAs miR-221 and miR-222 regulate the reprogramming of macrophages during the development of lipopolysaccharide tolerance, and increased expression of these microRNAs is associated with immunosuppression and poor prognosis in patients with sepsis.

doi: 10.1038/s41586-018-0253-5


OTULIN limits cell death and inflammation by deubiquitinating LUBAC p.120

OTULIN, which removes ubiquitin chains deposited by LUBAC, promotes LUBAC activity by preventing its auto-ubiquitination, thereby supporting normal mouse embryo development and preventing pro-inflammatory cell death in adult mice.

doi: 10.1038/s41586-018-0256-2


Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations p.125

A new mechanism of acquired clinical resistance in two patients with acute myeloid leukaemia driven by mutant IDH2 is described, in which a second-site mutation on the wild-type allele induces therapeutic resistance to IDH2 inhibitors.

doi: 10.1038/s41586-018-0251-7

分子生物学:ヘリカーゼDed1pは5′ UTR内のほぼコグネイトな翻訳開始コドンの使用を制御する

The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs p.130

The helicase Ded1p associates with the pre-initiation complex and influences translation from near-cognate initiation codons by controlling the levels of mRNA secondary structure in 5′ untranslated regions.

doi: 10.1038/s41586-018-0258-0


Cryo-EM structure of an essential Plasmodium vivax invasion complex p.135

Structural studies show that conserved residues in Plasmodium vivax reticulocyte-binding protein 2b determine interactions with transferrin receptor 1 that are essential for host invasion, suggesting avenues for designing vaccines that work across P. vivax strains.

doi: 10.1038/s41586-018-0249-1

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