Volume 554 Number 7692



SpaceX ignites big dreams p.275

The successful launch of the Falcon Heavy rocket was a stunning moment that opens the way for commercial exploration of deep space.

doi: 10.1038/d41586-018-01877-7


Don’t jump to conclusions about climate change and civil conflict p.275

Many studies that link global warming to civil unrest are biased and exacerbate stigma about the developing world.

doi: 10.1038/d41586-018-01875-9


From proposals to snarks: the messages that scientists sneak into their papers p.276

Researchers have hidden secret notes in their manuscripts for decades, but there are risks.

doi: 10.1038/d41586-018-01876-8



Tree rings reveal increased fire risk for southwestern US p.283

Historical record of wildfires points to climate patterns that could prime the region for an intense fire season.

doi: 10.1038/d41586-018-01686-y


Trump science budget sows confusion p.284

US president makes last-minute decision to abandon proposal for major cuts to National Institutes of Health, National Science Foundation and Department of Energy’s science office.

doi: 10.1038/d41586-018-01985-4


Wild primates threaten efforts to wipe out skin disease p.286

Efforts to combat disfiguring skin disease fail to account for primate hosts.

doi: 10.1038/d41586-018-01703-0


Deluge of astronomical data will soon hit South Africa p.286

The expansion of a telescope network creates a thirst for more data-handling expertise and infrastructure.

doi: 10.1038/d41586-018-01838-0


US science agency will require universities to report sexual harassment p.287

The National Science Foundation says institutions it supports must disclose when researchers are found to have violated policies or are put on leave pending investigation.

doi: 10.1038/d41586-018-01744-5

News Features


The quantum internet has arrived (and it hasn’t) p.289


doi: 10.1038/d41586-018-01835-3

News & Views


Space physics: The origin of pulsating auroras p.302


doi: 10.1038/d41586-018-01669-z


Animal behaviour: Brainpower boost for birds in large groups p.303


doi: 10.1038/d41586-018-01487-3


Neuroscience: Burst firing sets the stage for depression p.304


doi: 10.1038/d41586-018-01588-z


Neuroscience: Working memory freed from the past p.306


doi: 10.1038/d41586-018-01418-2


Condensed-matter physics: The two faces of a magnetic honeycomb p.307


doi: 10.1038/d41586-018-01747-2


Medical research: On the trail of invasive cells in breast cancer p.308


doi: 10.1038/d41586-018-01634-w



Genomics of the origin and evolution of Citrus OPEN p.311

The origin, evolution and domestication of Citrus and the genealogy of the most important wild and cultivated citrus varieties.

doi: 10.1038/nature25447


Ketamine blocks bursting in the lateral habenula to rapidly relieve depression p.317

The rapid antidepressant activity of ketamine results from reversal of increased burst firing and synchronization in the lateral habenula in rat and mouse models of depression.

doi: 10.1038/nature25509


Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression p.323

Increased expression of the potassium channel Kir4.1 on astrocytes in the lateral habenula drives neuronal bursting in rodent models of depression.

doi: 10.1038/nature25752


Teneurin-3 controls topographic circuit assembly in the hippocampus p.328

The transmembrane protein teneurin-3 is expressed in multiple topographically interconnected areas of the hippocampal region and acts in both projection and target neurons to control wiring specificity from CA1 to the subiculum.

doi: 10.1038/nature25463



A parsec-scale optical jet from a massive young star in the Large Magellanic Cloud p.334

Observations of a highly collimated, parsec-scale jet emitted from a massive young stellar object in the Large Magellanic Cloud indicate that jet launching and collimation are independent of stellar mass.

doi: 10.1038/nature25189


Pulsating aurora from electron scattering by chorus waves p.337

High-angular-resolution measurements allow the direct observation of the scattering of energetic electrons by chorus waves in the magnetosphere, which causes quasiperiodic electron precipitation that gives rise to pulsating aurorae.

doi: 10.1038/nature25505


A spin–orbital-entangled quantum liquid on a honeycomb lattice p.341

A quantum-liquid state of spin–orbital-entangled magnetic moments is observed in the 5d-electron honeycomb iridate H3LiIr2O6, evidenced by the absence of magnetic ordering down to 0.05 kelvin.

doi: 10.1038/nature25482


Freezing on a sphere p.346

Freezing on a spherical surface is shown to proceed by the sequestration of defects into 12 icosahedrally coordinated ‘seas’ that enable the formation of a crystalline ‘continent’ with long-range orientational order.

doi: 10.1038/nature25468


Southern Hemisphere climate variability forced by Northern Hemisphere ice-sheet topography p.351

An Antarctic ice core reveals that, during the last ice age, the topography of Northern Hemisphere ice sheets shifted tropical Pacific convection eastward, increasing climate variability in the high southern latitudes.

doi: 10.1038/nature24669


Global patterns of declining temperature variability from the Last Glacial Maximum to the Holocene p.356

Temperature variability decreased globally by a factor of four between the Last Glacial Maximum and the Holocene epoch, as a result of changes in the meridional temperature gradient.

doi: 10.1038/nature25454


Fluctuating interaction network and time-varying stability of a natural fish community p.360

A method for modelling time-varying dynamic stability in a natural marine fish community finds that seasonal patterns in community stability are driven by species diversity and interspecific interactions.

doi: 10.1038/nature25504


Cognitive performance is linked to group size and affects fitness in Australian magpies p.364

Wild Australian magpies (Cracticus tibicen dorsalis) living in large groups show increased cognitive performance, which is associated with increased reproductive success.

doi: 10.1038/nature25503


Posterior parietal cortex represents sensory history and mediates its effects on behaviour p.368

A working memory task in rats demonstrates that the posterior parietal cortex is a critical locus for the representation and use of prior stimulus information.

doi: 10.1038/nature25510


c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont p.373

The transcription factor c-MAF is required for the generation of Helicobacter-specific regulatory T cells that selectively restrain pro-inflammatory TH17 cells; the absence of c-MAF in mouse regulatory T cells results in pathobiont-dependent inflammatory bowel disease.

doi: 10.1038/nature25500


Asparagine bioavailability governs metastasis in a model of breast cancer p.378

In a mouse model of breast cancer, asparagine bioavailability strongly influences metastasis and this is correlated with the production of proteins that regulate the epithelial-to-mesenchymal transition, which provides at least one potential mechanism for how a single amino acid could regulate metastatic progression.

doi: 10.1038/nature25465

細胞生物学:ミトコンドリア–リソソーム間の接触はRAB7 GTP加水分解を介してミトコンドリアの分裂を調節する

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis p.382

Formation of inter-organelle contacts between mitochondria and lysosomes, regulated by lysosomal RAB7 GTP hydrolysis, allows for bidirectional regulation of mitochondrial and lysosomal dynamics.

doi: 10.1038/nature25486


Structural basis for DNMT3A-mediated de novo DNA methylation p.387

A crystal structure of DNMT3A and its regulatory partner DNMT3L bound to DNA reveals the mechanistic basis for DNMT3A-mediated DNA methylation and establishes its aetiological link to human disease.

doi: 10.1038/nature25477

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