Volume 549 Number 7673


科学研究とその出版過程における透明性は大きく改善されており、Nature Researchもこれに関してさまざまな取り組みを行っている。

Steps towards transparency in research publishing p.431

As research and editorial processes become increasingly open, scientists and editors need to be proactive but also alert to risks.

doi: 10.1038/549431a


Scientists see opportunity and risks in Catalan independence p.432

The upcoming referendum is unsettling researchers.

doi: 10.1038/549432b


World’s botanic gardens should work together p.432

A study suggests a possible way to save more species.

doi: 10.1038/549432a



Hurricanes Harvey and Irma send scientists scrambling for data p.439

Even before getting their own lives settled, teams collect information on storm behaviour and their effects on the ecosystem.

doi: 10.1038/549439a


High-energy cosmic rays come from outside our Galaxy p.440

Giant observatory announces long-awaited result.

doi: 10.1038/nature.2017.22655


What Germany’s election results mean for science p.441

A new coalition could face battles over gene editing and climate regulations.

doi: 10.1038/nature.2017.22667


Deadly Mexico quakes not linked p.442

Despite close timing, researchers doubt that the first big tremor set off the second.

doi: 10.1038/549442a


Giant iceberg’s split exposes hidden ecosystem p.443

Biologists rush to study creatures living beneath Larsen C ice shelf before they disappear.

doi: 10.1038/549443a


Sexual competition among ducks wreaks havoc on penis size p.443

When forced to compete for mates, some birds develop longer penises and others almost nothing at all.

doi: 10.1038/nature.2017.22648

News Features


The drug-maker's guide to the galaxy p.445


doi: 10.1038/549445a


Living on the edge p.448

ケンブリッジ大学(英国)の物性物理学者Gilbert Lonzarich氏は、材料科学の限界を押し広げ、物質の量子状態の研究に革命をもたらした。

doi: 10.1038/549448a

News & Views


Cancer: Drain the swamp to beat glioma p.460


doi: 10.1038/nature24141


Geochemistry: Evaporating planetesimals p.461


doi: 10.1038/549461a


Leukaemia: Vitamin C regulates stem cells and cancer p.462


doi: 10.1038/nature23548


Condensed-matter physics: Taking control of spin currents p.464


doi: 10.1038/549464a


Cancer: Bad blood promotes tumour progression p.465


doi: 10.1038/549465a


Neuroscience: Mum's bacteria linked to baby's behaviour p.466


doi: 10.1038/nature24139



Axonal synapse sorting in medial entorhinal cortex p.469

Path-length-dependent axonal synapse sorting of local presynaptic axons of excitatory neurons in the rat medial entorhinal cortex results in sequential targeting of inhibitory and excitatory neurons, which are connected by a cellular feedforward inhibition circuit.

doi: 10.1038/nature24005


Ascorbate regulates haematopoietic stem cell function and leukaemogenesis p.476

Ascorbate depletion in mice increased haematopoietic stem-cell frequency and promoted leukaemogenesis, partly by reducing the function of the Tet2 tumour suppressor enzyme.

doi: 10.1038/nature23876


Reversing behavioural abnormalities in mice exposed to maternal inflammation p.482

The authors define a specific cortical subregion of the somatosensory cortex as a critical region of dysfunction that is causal to the emergence of abnormal social and repetitive behaviours in mice exposed to maternal inflammation.

doi: 10.1038/nature23909



The close environments of accreting massive black holes are shaped by radiative feedback p.488

Radiation pressure on dusty gas is the main physical mechanism that regulates the distribution of the circumnuclear material that obscures many supermassive black holes.

doi: 10.1038/nature23906


Maximal Rashba-like spin splitting via kinetic-energy-coupled inversion-symmetry breaking p.492

Asymmetry in surface hopping energies in different atomic layers of delafossite oxides results in some of the largest known Rashba-like spin splittings.

doi: 10.1038/nature23898


Mimicking biological stress–strain behaviour with synthetic elastomers p.497

A polymer code based on a triplet of parameters—network strand length, side-chain length and grafting density—enables materials to be designed with specific combinations of mechanical properties to mimic biological materials.

doi: 10.1038/nature23673


SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis p.502

The enzyme LepI is found to be capable of catalysing several natural-product pericyclic transformations, including a hetero-Diels–Alder reaction and a retro-Claisen rearrangement.

doi: 10.1038/nature23882


Earth’s volatile contents established by melting and vaporization p.507

The pattern of volatile element depletion in the silicate Earth suggests that melting and vaporization on precursor bodies and during accretion were responsible for the volatile element contents of Earth.

doi: 10.1038/nature23645


Magnesium isotope evidence that accretional vapour loss shapes planetary compositions p.511

The measurement of magnesium isotope ratios at improved accuracy suggests that planetary compositions result from fractionation between liquid and vapour, followed by vapour escape during accretionary growth.

doi: 10.1038/nature23899


Early trace of life from 3.95 Ga sedimentary rocks in Labrador, Canada p.516

The authors provide evidence for the existence of life on Earth in the earliest known sedimentary rocks and suggest that the presence of organic carbon, and low stable-isotope values of graphite from sedimentary rocks in Labrador pushes back the existence of organic life to beyond 3.95 billion years.

doi: 10.1038/nature24019

遺伝学:アイスランド人の両親と子の1548トリオで見られた、ヒト生殖系列de novo変異に及ぼす親の影響

Parental influence on human germline de novo mutations in 1,548 trios from Iceland p.519

Whole-genome sequencing data of 14,688 Icelanders, including 1,548 parent–offspring trios, show how the age and sex of parents affect the rate and spectrum of de novo mutations.

doi: 10.1038/nature24018


ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy p.523

ApoE4 exacerbates tau pathogenesis, neuroinflammation and tau-mediated neurodegeneration independently of brain amyloid-β pathology, and exerts a ‘toxic’ gain of function whereas its absence is protective.

doi: 10.1038/nature24016


Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring p.528

Maternal immune activation (MIA)-mediated abnormal behavioural phenotypes require defined gut commensal bacteria for the induction of IL-17-producing T helper 17 cells.

doi: 10.1038/nature23910


Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma p.533

The growth of adult and paediatric brain tumours depends on a microenvironmental signalling pathway involving the activity-regulated secretion of neuroligin-3 (NLGN3) from normal neurons and oligodendrocyte precursor cells, highlighting the potential of NLGN3 as a therapeutic target.

doi: 10.1038/nature24014


Comparative glycoproteomics of stem cells identifies new players in ricin toxicity p.538

A novel quantitative approach to identify intact glycopeptides from comparative proteomic data sets, allowing inference of complex glycan structures and direct mapping of them to sites within the associated proteins at the proteome scale.

doi: 10.1038/nature24015


Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer p.543

Analysis of global remethylation in mouse embryos at several developmental stages identifies an epigenetic landscape that partitions extraembryonic tissues within the embryo and resembles a frequent, global departure in genome regulation in human cancers.

doi: 10.1038/nature23891


Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN p.548

CYREN is a direct inhibitor of classical non-homologous end joining that promotes error-free repair by homologous recombination during the S and G2 phases of the cell cycle.

doi: 10.1038/nature24023

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