Volume 549 Number 7672



Take stock of research ethics in human genome editing p.307

Progress in the use of CRISPR–Cas9 for human germline editing highlights some pressing ethical considerations for research on embryos.

doi: 10.1038/549307a


言語学者Florian Jaegerによるセクハラ問題では、所属先の米国ロチェスター大学にも激しい批判が。

Scientists' sexual-harassment case sparks protests at University of Rochester p.315

Researchers who worked with Florian Jaeger have filed a complaint with the US government after the university cleared his name.

doi: 10.1038/nature.2017.22620


Sharks can live a lot longer than researchers realized p.316

Errors in past studies could undermine conservation plans.

doi: 10.1038/nature.2017.22626


Cassini crashes into Saturn — but could still deliver big discoveries p.317

Data from spacecraft could help determine the age of Saturn's rings and the persistence of its magnetic field.

doi: 10.1038/nature.2017.22619


Marine scientists allege Japan has blocked researchers from joining South Korean ship p.318

Controversy over vessel's name may impede oceanographic collaboration.

doi: 10.1038/nature.2017.22621


Researchers unite in quest for ‘standard model’ of the brain p.319

Modelled on big physics projects, the International Brain Lab will bring together some of the world’s pre-eminent neuroscientists to probe a single behaviour.

doi: 10.1038/549319a

News Features


How the Internet of cells has biologists buzzing p.322


doi: 10.1038/549322a

News & Views


Nanotechnology: A molecular assembler p.336


doi: 10.1038/549336a


Cell signalling: Red alert about lipid's role in skin cancer p.337


doi: 10.1038/nature23550


Materials science: Long-lived electrodes for plastic batteries p.339


doi: 10.1038/549339a


Neuroscience: From embryo mutation to adult degeneration p.340


doi: 10.1038/nature23547


Metallurgy: No more tears for metal 3D printing p.342


doi: 10.1038/549342a


Cell biology: The persistence of memory p.343


doi: 10.1038/nature23549



Rabies screen reveals GPe control of cocaine-triggered plasticity p.345

A rabies virus-based monosynaptic tracing method is used to show that the external globus pallidus plays a critical role in cocaine-induced behavioural plasticity.

doi: 10.1038/nature23888


The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation p.351

Neuromedin receptor NMUR1 is specifically expressed by a subpopulation of type 2 innate lymphoid cells and promotes the inflammatory response of these cells in response to allergens, indicating the importance of neuro-immune crosstalk in allergic responses.

doi: 10.1038/nature24029



A binary main-belt comet p.357

Analysis based on high-resolution observations from the Hubble Space Telescope shows that the asteroid 288P is a binary main-belt comet, with properties unlike any known binary asteroid.

doi: 10.1038/nature23892


Tunable interacting composite fermion phases in a half-filled bilayer-graphene Landau level p.360

Various fractional quantum Hall phases are observed in a new generation of bilayer-graphene-based van der Waals heterostructures, including an even-denominator state predicted to harbour non-Abelian anyons.

doi: 10.1038/nature23893


3D printing of high-strength aluminium alloys p.365

Zirconium nanoparticles introduced into aluminium alloy powders control solidification during 3D printing, enabling the production of crack-free materials with strengths comparable to the corresponding wrought material.

doi: 10.1038/nature23894


Metallic molybdenum disulfide nanosheet-based electrochemical actuators p.370

Electrochemical actuators based on exfoliated and restacked metallic MoS2 nanosheet electrodes can generate mechanical force in electrolyte solution on intercalation and deintercalation of ions.

doi: 10.1038/nature23668


Stereodivergent synthesis with a programmable molecular machine p.374

A molecular machine that can be programmed to position a substrate at one of two directing sites on a molecule, which control the stereochemistry of addition to the substrate, demonstrates complexity, precision and function previously only observed in nature.

doi: 10.1038/nature23677


The Apostasia genome and the evolution of orchids OPEN p.379

Comparing the whole genome sequence of Apostasia shenzhenica with transcriptome and genome data from five orchid subfamilies permits the reconstruction of an ancestral gene toolkit, providing insight into orchid origins, evolution and diversification.

doi: 10.1038/nature23897


Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors p.384

Surface diffusion of AMPA receptors, from extra-synaptic to synaptic sites at the plasma membrane, is essential for full long-term potentiation in hippocampal neurons and for fear conditioning in living mice.

doi: 10.1038/nature23658


A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease p.389

Braf V600E expression in resident macrophage progenitors leads to clonal expansion of ERK-activated microglia, which causes synaptic and neuronal loss in the brain and results in lethal neurodegenerative disease in adult mice.

doi: 10.1038/nature23672


cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders p.394

A molecular mechanism for the sensitive detection of long and U-turn DNA by cyclic GMP–AMP synthase (cGAS) both in vitro and in human cells.

doi: 10.1038/nature23890


Palmitoylation-dependent activation of MC1R prevents melanomagenesis p.399

The protein modification palmitoylation increases the ability of variant forms of the melanocortin-1 receptor (MC1R) to induce pigmentation, and this is linked to reduced development of melanomas.

doi: 10.1038/nature23887


Competing memories of mitogen and p53 signalling control cell-cycle entry p.404

Mother cells transmit mitogen-induced CCND1 mRNA and DNA damage-induced p53 protein to newly born daughter cells, where synthesized cyclin D1 and the p53-regulated CDK inhibitor p21 directly compete to decide between proliferation and quiescence.

doi: 10.1038/nature23880


Alternative evolutionary histories in the sequence space of an ancient protein p.409

Combining ancestral protein reconstruction with deep mutational scanning to characterize alternative histories in the sequence space around an ancient transcription factor reveals hundreds of alternative protein sequences that use diverse biochemical mechanisms to perform the derived function at least as well as the historical outcome.

doi: 10.1038/nature23902


The cryo-electron microscopy structure of human transcription factor IIH p.414

The cryo-electron microscopy structure of the ten-subunit human transcription factor IIH, revealing the molecular architecture of the TFIIH core complex, the detailed structures of its constituent XPB and XPD ATPases, and how the core and kinase subcomplexes of TFIIH are connected.

doi: 10.1038/nature23903

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