Volume 558 Number 7710



Curbing opioid addiction needs more than new drugs p.343

Plans by the National Institutes of Health to tackle a drug epidemic in the United States can treat only the symptoms, not the cause.

doi: 10.1038/d41586-018-05466-6


Evidence synthesis needs greater incentives p.344

Enlarge and better reward efforts that examine past discoveries to set policy and agendas.

doi: 10.1038/d41586-018-05464-8


Nature’s under-representation of women p.344

Women continue to form too small a proportion of this journal’s authors and referees.

doi: 10.1038/d41586-018-05465-7



World Cup ban on radioactive chemicals frustrates Russian biochemistry labs p.351

The restrictions exacerbate what is already a difficult situation for Russian biochemists.

doi: 10.1038/d41586-018-05423-3


Sexual harassment is rife in the sciences, finds landmark US study p.352

Existing policies to address the issue are ineffective, concludes a long-awaited report from the National Academies of Sciences, Engineering, and Medicine.

doi: 10.1038/d41586-018-05404-6


Microsoft’s purchase of GitHub leaves some scientists uneasy p.353

They fear the online platform will become less open, but other researchers say the buyout could make GitHub more useful.

doi: 10.1038/d41586-018-05426-0


New human gene tally reignites debate p.354

Some fifteen years after the human genome was sequenced, researchers still can’t agree on how many genes it contains.

doi: 10.1038/d41586-018-05462-w


Cancer researchers target the dormant cells that seed tumours p.355

Different approach to treatment zeroes in on the silent cells that break off of tumours — and aims to keep them asleep.

doi: 10.1038/d41586-018-05445-x

News Features


Bias detectives: the researchers striving to make algorithms fair p.357


doi: 10.1038/d41586-018-05469-3

News & Views


DNA damage: Cell umbrella protects stem cells from DNA damage p.374


doi: 10.1038/d41586-018-05166-1


Astronomy: Missing matter found in the cosmic web p.375


doi: 10.1038/d41586-018-05432-2


Clinical oncology: New windows open for immunotherapy in lung cancer p.376


doi: 10.1038/d41586-018-05312-9


Marine geology: Sea-level rise could overwhelm coral reefs p.378


doi: 10.1038/d41586-018-04879-7


Nanoscience: Frictionless gas flow observed in perfectly flat-walled nanochannels p.379


doi: 10.1038/d41586-018-05403-7


Stem cells: Debate over the identity of an intestinal niche-cell population settled p.380


doi: 10.1038/d41586-018-05281-z



Antarctic ice shelf disintegration triggered by sea ice loss and ocean swell p.383

Less sea ice allowed ocean swells to flex weakened ice shelves in Antarctica, contributing to their collapse.

doi: 10.1038/s41586-018-0212-1


An Early Cretaceous eutherian and the placental–marsupial dichotomy p.390

Morphological studies and phylogenetic analyses based on the newly discovered Early Cretaceous eutherian mammal Ambolestes zhoui show that the oldest purported metatherian Sinodelphys is instead a eutherian.

doi: 10.1038/s41586-018-0210-3


Loss of coral reef growth capacity to track future increases in sea level p.396

Analyses of current coral reef growth rates in the tropical western Atlantic and Indian Ocean show that few reefs will have the capacity to track sea-level rise projections under Representative Concentration Pathway scenarios without sustained ecological recovery.

doi: 10.1038/s41586-018-0194-z


Structural basis of mitochondrial receptor binding and constriction by DRP1 p.401

Cryo-electron microscopy is used to resolve the structure of human dynamin-related protein 1 co-assembled with its receptor mitochondrial dynamics protein of 49 kDa, along with an analysis of structure- and disease-based mutations.

doi: 10.1038/s41586-018-0211-2



Observations of the missing baryons in the warm–hot intergalactic medium p.406

Observations of two absorbers of highly ionized oxygen in the X-ray spectrum of a quasar account for the missing baryons in the Universe.

doi: 10.1038/s41586-018-0204-1


Gate-tunable frequency combs in graphene–nitride microresonators p.410

Coupling graphene sheets with a silicon nitride ring microresonator allows the nonlinear cavity dynamics to be altered by a gate voltage, resulting in tunable, chip-scale, optical frequency combs.

doi: 10.1038/s41586-018-0216-x


Comprehensive suppression of single-molecule conductance using destructive σ-interference p.415

Highly insulating silicon-based molecules, engineered so that conduction is fully suppressed by σ quantum interference even for molecules less than a nanometre long, could prove useful in molecular-scale electronic circuitry.

doi: 10.1038/s41586-018-0197-9


Ballistic molecular transport through two-dimensional channels p.420

Specular scattering of atoms of helium gas flowing through atomically flat, two-dimensional channels results in frictionless gas flow, which is much faster than expected assuming purely diffusive scattering.

doi: 10.1038/s41586-018-0203-2


Heterointerface effects in the electrointercalation of van der Waals heterostructures p.425

The electrointercalation of lithium into van der Waals heterostructures of graphene, hexagonal boron nitride and molybdenum dichalcogenides is studied at the level of individual atomic interfaces.

doi: 10.1038/s41586-018-0205-0


Extensive retreat and re-advance of the West Antarctic Ice Sheet during the Holocene p.430

Radiocarbon dating of sediment cores and ice-penetrating radar observations are used to demonstrate that the West Antarctic Ice Sheet has not retreated progressively during the Holocene epoch, but has instead showed periods of retreat and re-advance.

doi: 10.1038/s41586-018-0208-x


Quantitative phosphoproteomic analysis of the molecular substrates of sleep need p.435

A subset of synaptic proteins are cumulatively phosphorylated during wakefulness and dephosphorylated during sleep, in accordance with sleep need; this may represent a common mechanism underlying regulation of both synaptic homeostasis and sleep–wake homeostasis.

doi: 10.1038/s41586-018-0218-8


Novel soil bacteria possess diverse genes for secondary metabolite biosynthesis p.440

Metagenomic and soil microcosm analyses identify abundant biosynthetic gene clusters in genomes of microorganisms from a northern Californian grassland ecosystem that provide a potential source for the future development of bacterial natural products.

doi: 10.1038/s41586-018-0207-y


Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche p.445

Melanocytes above the haematopoietic niche protect haematopoietic stem cells from ultraviolet-light-induced DNA damage in aquatic vertebrates throughout evolution; this niche moved to the bone marrow during the transition to terrestrial life.

doi: 10.1038/s41586-018-0213-0


GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells p.449

GLI1-positive cells in the colon secrete Wnt ligands and thereby support homeostasis of intestinal stem cells.

doi: 10.1038/s41586-018-0190-3


Induction and transcriptional regulation of the co-inhibitory gene module in T cells p.454

A module of co-inhibitory T cell receptors, driven by the cytokine IL-27, is identified in mice that is regulated by the transcription factors PRDM1 and c-MAF.

doi: 10.1038/s41586-018-0206-z


A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II p.460

The kinase Cdk9 and the phosphatase Dis2 regulate the termination of transcription in fission yeast in part by controlling the phosphorylation state of the elongation factor Spt5.

doi: 10.1038/s41586-018-0214-z


Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36 p.465

A mechanism for the unfolding of guanine-rich DNA ‘quadruplexes’ by helicases is suggested, based on the structure of a DNA-bound helicase.

doi: 10.1038/s41586-018-0209-9


Structural basis for regulation of human acetyl-CoA carboxylase p.470

Cryo-electron microscopy studies of distinct, catalytically active and inactive filaments of human acetyl-CoA carboxylase 1 reveal the structural basis of its regulation.

doi: 10.1038/s41586-018-0201-4

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