Wanted: better systems for turning evidence into action p.7
doi: 10.1038/d41586-022-00559-9
Volume 603 Number 7899
今週のハイライト
Cover Story: 改良された酵素：ビアリール化合物の効率の良い合成法が生体触媒を操作して得られた
物性物理学: 磁性トポロジカル物質
加速器物理学: プラズマ粒子加速器の進展
物性物理学: シリコン上に形成されたトポロジカルナノドメイン
材料科学: 炭素同位体の拡散の画像化
エネルギー科学: 全ペロブスカイトタンデム太陽電池で新記録
地球科学: 冥王代の水和した不均質なマントル
生物地球化学: 春の奔流
社会科学: 温暖化を抑える要因
神経科学: 広域の機構による特異的なニューロン配線の調節
神経変性疾患: FTD/ALS関連バリアントとTDP-43の結び付き
微生物学: 肺の微生物相と脳の自己免疫の結び付き
免疫学: 重症COVID-19の炎症病態にはcGAS–STING経路が関与する
自己免疫疾患: 多発性硬化症の一卵性双生児不一致例研究
細胞生物学: 低用量メトホルミンの作用機構
がん: 複数のがんに効く薬剤の組み合わせを探す
ウイルス学: 構造から判明したラッサウイルスの受容体認識機構
構造生物学: NALCNチャネロソーム複合体の構造と機能
目次
Editorials
Nature is trialling transparent peer review — the early results are encouraging p.8
doi: 10.1038/d41586-022-00493-w
News
Wuhan market was epicentre of pandemic’s start, studies suggest p.15
doi: 10.1038/d41586-022-00584-8
Fossil fish reveal timing of asteroid that killed the dinosaurs p.17
doi: 10.1038/d41586-022-00511-x
A year on Mars: How NASA’s Perseverance hit a geological jackpot p.18
doi: 10.1038/d41586-022-00469-w
Asteroids, Hubble rival and Moon base: China sets out space agenda p.19
doi: 10.1038/d41586-022-00439-2
Two scientists will replace disgraced US science adviser Eric Lander p.21
doi: 10.1038/d41586-022-00484-x
News Features
Omicron’s lasting mysteries: four questions scientists are racing to answer p.22
doi: 10.1038/d41586-022-00428-5
Hundreds of COVID trials could provide a deluge of new drugs p.25
doi: 10.1038/d41586-022-00562-0
News & Views
Mechanism underlying a risk gene in neurodegeneration p.33
doi: 10.1038/d41586-022-00383-1
Plasmas primed for rapid pulse production p.34
doi: 10.1038/d41586-022-00544-2
Isotopes tracked on a sub-nanometre scale using electron spectroscopy p.36
doi: 10.1038/d41586-022-00545-1
Light-dependent development is tailored in visual neurons p.37
doi: 10.1038/d41586-022-00463-2
Lung microbes mediate spinal-cord autoimmunity p.38
doi: 10.1038/d41586-022-00468-x
Review
Progress and prospects in magnetic topological materials p.41
doi: 10.1038/s41586-021-04105-x
Articles
A persistent ultraviolet outflow from an accreting neutron star binary transient p.52
doi: 10.1038/s41586-021-04324-2
Recovery time of a plasma-wakefield accelerator p.58
doi: 10.1038/s41586-021-04348-8
High-density switchable skyrmion-like polar nanodomains integrated on silicon p.63
doi: 10.1038/s41586-021-04338-w
Imaging of isotope diffusion using atomic-scale vibrational spectroscopy p.68
doi: 10.1038/s41586-022-04405-w
All-perovskite tandem solar cells with improved grain surface passivation p.73
doi: 10.1038/s41586-021-04372-8
Biocatalytic oxidative cross-coupling reactions for biaryl bond formation p.79
doi: 10.1038/s41586-021-04365-7
A wet heterogeneous mantle creates a habitable world in the Hadean p.86
doi: 10.1038/s41586-021-04371-9
The Mesozoic terminated in boreal spring p.91
doi: 10.1038/s41586-022-04446-1
Genetic associations of protein-coding variants in human disease p.95
doi: 10.1038/s41586-022-04394-w
Determinants of emissions pathways in the coupled climate–social system p.103
doi: 10.1038/s41586-022-04423-8
A global timing mechanism regulates cell-type-specific wiring programmes p.112
doi: 10.1038/s41586-022-04418-5
A biophysical account of multiplication by a single neuron p.119
doi: 10.1038/s41586-022-04428-3
TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A p.124
doi: 10.1038/s41586-022-04424-7
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A p.131
doi: 10.1038/s41586-022-04436-3
The lung microbiome regulates brain autoimmunity p.138
doi: 10.1038/s41586-022-04427-4
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19 p.145
doi: 10.1038/s41586-022-04421-w
Twin study reveals non-heritable immune perturbations in multiple sclerosis p.152
doi: 10.1038/s41586-022-04419-4
Low-dose metformin targets the lysosomal AMPK pathway through PEN2 p.159
doi: 10.1038/s41586-022-04431-8
Effective drug combinations in breast, colon and pancreatic cancer cells p.166
doi: 10.1038/s41586-022-04437-2
Structure and receptor recognition by the Lassa virus spike complex p.174
doi: 10.1038/s41586-022-04429-2
Structural architecture of the human NALCN channelosome p.180
doi: 10.1038/s41586-021-04313-5
