Volume 603 Number 7899


Wanted: better systems for turning evidence into action p.7

doi: 10.1038/d41586-022-00559-9

Nature is trialling transparent peer review — the early results are encouraging p.8

doi: 10.1038/d41586-022-00493-w


Wuhan market was epicentre of pandemic’s start, studies suggest p.15

doi: 10.1038/d41586-022-00584-8

Fossil fish reveal timing of asteroid that killed the dinosaurs p.17

doi: 10.1038/d41586-022-00511-x

A year on Mars: How NASA’s Perseverance hit a geological jackpot p.18

doi: 10.1038/d41586-022-00469-w

Asteroids, Hubble rival and Moon base: China sets out space agenda p.19

doi: 10.1038/d41586-022-00439-2

Two scientists will replace disgraced US science adviser Eric Lander p.21

doi: 10.1038/d41586-022-00484-x

News Features

Omicron’s lasting mysteries: four questions scientists are racing to answer p.22

doi: 10.1038/d41586-022-00428-5

Hundreds of COVID trials could provide a deluge of new drugs p.25

doi: 10.1038/d41586-022-00562-0

News & Views

Mechanism underlying a risk gene in neurodegeneration p.33

doi: 10.1038/d41586-022-00383-1

Plasmas primed for rapid pulse production p.34

doi: 10.1038/d41586-022-00544-2

Isotopes tracked on a sub-nanometre scale using electron spectroscopy p.36

doi: 10.1038/d41586-022-00545-1

Light-dependent development is tailored in visual neurons p.37

doi: 10.1038/d41586-022-00463-2

Lung microbes mediate spinal-cord autoimmunity p.38

doi: 10.1038/d41586-022-00468-x


Progress and prospects in magnetic topological materials p.41

doi: 10.1038/s41586-021-04105-x


A persistent ultraviolet outflow from an accreting neutron star binary transient p.52

doi: 10.1038/s41586-021-04324-2

Recovery time of a plasma-wakefield accelerator p.58

doi: 10.1038/s41586-021-04348-8

High-density switchable skyrmion-like polar nanodomains integrated on silicon p.63

doi: 10.1038/s41586-021-04338-w

Imaging of isotope diffusion using atomic-scale vibrational spectroscopy p.68

doi: 10.1038/s41586-022-04405-w

All-perovskite tandem solar cells with improved grain surface passivation p.73

doi: 10.1038/s41586-021-04372-8

Biocatalytic oxidative cross-coupling reactions for biaryl bond formation p.79

doi: 10.1038/s41586-021-04365-7

A wet heterogeneous mantle creates a habitable world in the Hadean p.86

doi: 10.1038/s41586-021-04371-9

The Mesozoic terminated in boreal spring p.91

doi: 10.1038/s41586-022-04446-1

Genetic associations of protein-coding variants in human disease p.95

doi: 10.1038/s41586-022-04394-w

Determinants of emissions pathways in the coupled climate–social system p.103

doi: 10.1038/s41586-022-04423-8

A global timing mechanism regulates cell-type-specific wiring programmes p.112

doi: 10.1038/s41586-022-04418-5

A biophysical account of multiplication by a single neuron p.119

doi: 10.1038/s41586-022-04428-3

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A p.124

doi: 10.1038/s41586-022-04424-7

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A p.131

doi: 10.1038/s41586-022-04436-3

The lung microbiome regulates brain autoimmunity p.138

doi: 10.1038/s41586-022-04427-4

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19 p.145

doi: 10.1038/s41586-022-04421-w

Twin study reveals non-heritable immune perturbations in multiple sclerosis p.152

doi: 10.1038/s41586-022-04419-4

Low-dose metformin targets the lysosomal AMPK pathway through PEN2 p.159

doi: 10.1038/s41586-022-04431-8

Effective drug combinations in breast, colon and pancreatic cancer cells p.166

doi: 10.1038/s41586-022-04437-2

Structure and receptor recognition by the Lassa virus spike complex p.174

doi: 10.1038/s41586-022-04429-2

Structural architecture of the human NALCN channelosome p.180

doi: 10.1038/s41586-021-04313-5

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