Volume 558 Number 7708



Science benefits from diversity p.5

Improving the participation of under-represented groups is not just fairer — it could produce better research.

doi: 10.1038/d41586-018-05326-3


Marketing personalized cancer treatments requires careful language p.5

Therapies tailored to individual tumours must not be oversold.

doi: 10.1038/d41586-018-05323-6


Europe’s top science advisers send clear message on food production p.6

Report on plant protection highlights the fragmented nature of current decision-making on agriculture.

doi: 10.1038/d41586-018-05327-2



Max Planck scientists criticize handling of animal-rights charges against leading neuroscientist p.13

They say the Max Planck Society’s reaction to the indictment of Nikos Logothetis has disrupted research.

doi: 10.1038/d41586-018-05187-w


US EPA science advisers question ‘secret science’ rule on data transparency p.15

Independent board will review agency decisions to repeal or change climate regulations and rules on the use of non-public data.

doi: 10.1038/d41586-018-05319-2


Hurricanes slow their roll around the world p.15

Storms' slowdown means more rain, and potentially more damage, for populated areas.

doi: 10.1038/d41586-018-05324-5


Europe’s top science funder shows high-risk research pays off p.16

The European Research Council publishes its third annual impact assessment of the projects it funds.

doi: 10.1038/d41586-018-05325-4

2018年のカブリナノサイエンス賞はCRISPR–Cas9系の開発に対して授与され、そこにはこれまであまり注目されてこなかったVirginijus Siksnys氏の名前も。

Million-dollar Kavli prize recognizes scientist scooped on CRISPR p.17

Award goes to biochemists Virginijus Siksnys, whose lab independently developed the gene-editing tool, Emmanuelle Charpentier and Jennifer Doudna.

doi: 10.1038/d41586-018-05308-5

News Features


These labs are remarkably diverse — here’s why they’re winning at science p.19


doi: 10.1038/d41586-018-05316-5

News & Views


Mammalian evolution: A 3D view of early mammals p.32


doi: 10.1038/d41586-018-05134-9


Astronomy: A fresh approach to stellar benchmarking p.33


doi: 10.1038/d41586-018-05306-7


Developmental biology: Stem cells provide evidence for an organizer in human embryos p.35


doi: 10.1038/d41586-018-05115-y


Climate change: Tropical cyclones are becoming sluggish p.36


doi: 10.1038/d41586-018-05303-w


Neuroscience: Motion processing picks up speed in the brain p.38


doi: 10.1038/d41586-018-04289-9


Engineering: Two artificial synapses are better than one p.39


doi: 10.1038/d41586-018-05297-5



Long-distance navigation and magnetoreception in migratory animals p.50

A Review of the cues and mechanisms used by animals to navigate over long distances, with a particular emphasis on magnetoreception.

doi: 10.1038/s41586-018-0176-1



The many possible climates from the Paris Agreement’s aim of 1.5°C warming p.41

The results of efforts to limit global mean warming to below 1.5 °C may include many possible future world climates.

doi: 10.1038/s41586-018-0181-4



Equivalent-accuracy accelerated neural- network training using analogue memory p.60

Analogue-memory-based neural-network training using non-volatile-memory hardware augmented by circuit simulations achieves the same accuracy as software-based training but with much improved energy efficiency and speed.

doi: 10.1038/s41586-018-0180-5


Euryhaline ecology of early tetrapods revealed by stable isotopes p.68

An approach using multiple stable isotopes reveals that early tetrapods of the Devonian period were euryhaline animals that inhabited aquatic environments of highly variable salinity.

doi: 10.1038/s41586-018-0159-2


Genomic atlas of the human plasma proteome p.73

A genetic atlas of the human plasma proteome, comprising 1,927 genetic associations with 1,478 proteins, identifies causes of disease and potential drug targets.

doi: 10.1038/s41586-018-0175-2


Cortical direction selectivity emerges at convergence of thalamic synapses p.80

Direction selectivity emerges de novo in layer 4 neurons of primary visual cortex through the convergence of synaptic inputs from thalamic neurons that respond with distinct time courses to visual stimuli in distinct locations.

doi: 10.1038/s41586-018-0148-5


天文学:木星の極付近でしばしば発生する600 MHzの雷空電

Prevalent lightning sferics at 600 megahertz near Jupiter’s poles p.87

Observations of broadband emission from lightning on Jupiter at 600 megahertz show a lightning discharge mechanism similar to that of terrestrial lightning and indicate increased moist convection near Jupiter’s poles.

doi: 10.1038/s41586-018-0156-5


A per-cent-level determination of the nucleon axial coupling from quantum chromodynamics p.91

Lattice quantum chromodynamics and a method inspired by the Feynman–Hellmann theorem are used to make a theoretical determination of the nucleon axial coupling with a precision of one per cent, giving the value 1.271 ± 0.013.

doi: 10.1038/s41586-018-0161-8


Observation of anisotropic magneto-Peltier effect in nickel p.95

A ‘magneto-Peltier effect’ produces cooling or heating in a material without junctions, by forcing a change in angle between the current and magnetization in a single ferromagnetic nickel slab.

doi: 10.1038/s41586-018-0143-x


Potential enthalpic energy of water in oils exploited to control supramolecular structure p.100

Less than 0.01 per cent by weight of water in an alkane solvent is sufficient to interact with co-dissolved supramolecular polymeric chains by hydrogen bonding and modulate the structure of the assembly.

doi: 10.1038/s41586-018-0169-0


A global slowdown of tropical-cyclone translation speed p.104

The translation speed of tropical cyclones has decreased globally by 10% over the past 70 years, compounding the increases in cyclone-related local rainfall that have resulted from anthropogenic warming.

doi: 10.1038/s41586-018-0158-3


Late-surviving stem mammal links the lowermost Cretaceous of North America and Gondwana p.108

An exceptionally preserved skull of Cifelliodon wahkarmoosuch sheds light on the evolution of the ancestral mammalian brain.

doi: 10.1038/s41586-018-0126-y


Body-size shifts in aquatic and terrestrial urban communities p.113

The urban-heat-island effect drives community-level shifts towards smaller body sizes; however, habitat fragmentation caused by urbanization favours larger body sizes in species with positive size–dispersal links.

doi: 10.1038/s41586-018-0140-0


Pairwise and higher-order genetic interactions during the evolution of a tRNA p.117

Mutagenesis of a yeast tRNA shows that the effects of mutations and how they interact varies both in magnitude and sign between genotypes.

doi: 10.1038/s41586-018-0170-7


Molecular tuning of electroreception in sharks and skates p.122

Shark and skate electrosensory cells use specific potassium channels to support either indiscriminate detection of electrical stimuli or selective frequency tuning, respectively, demonstrating adaptation of sensory systems through discrete molecular modifications.

doi: 10.1038/s41586-018-0160-9


The coding of valence and identity in the mammalian taste system p.127

The identity and hedonic value of tastes are encoded in distinct neural substrates; in mice, the amygdala is necessary and sufficient to drive valence-specific behaviours in response to bitter or sweet taste stimuli, and the cortex can independently represent taste identity.

doi: 10.1038/s41586-018-0165-4


Self-organization of a human organizer by combined Wnt and Nodal signalling p.132

Stimulation of Wnt and Nodal pathways in micropatterned human embryonic stem cell colonies induce these colonies to exhibit characteristic spatial expression patterns of the organizer and reproduce organizer function when grafted into a host embryo.

doi: 10.1038/s41586-018-0150-y

細胞生物学:beclin 1–BCL2オートファジー調節複合体の破壊はマウスで長命を促す

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice p.136

A knock-in mutation in beclin 1 that increases autophagy in mice extends animal lifespan, improves healthspan, and also rescues early lethality in mice deficient in the anti-ageing protein klotho.

doi: 10.1038/s41586-018-0162-7


Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells p.141

A data-driven analysis helps to identify specific roles of the Hippo signalling kinases Mst1 and Mst2 in integrating metabolic activity and cytokine signalling in dendritic cells, and thereby orchestrating immune cell function.

doi: 10.1038/s41586-018-0177-0

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