Volume 554 Number 7690



The scientist who predicted ice-sheet collapse — 50 years ago p.5

A seminal 1968 study warned of the demise of the West Antarctic Ice Sheet.

doi: 10.1038/d41586-018-01390-x


The serendipity test p.5

Scientists often herald the role of chance in research. A project in Britain aims to test the popular idea with evidence.

doi: 10.1038/d41586-018-01405-7


Nature journals tighten rules on non-financial conflicts p.6

Authors will be asked to declare any interests that might cloud objectivity.

doi: 10.1038/d41586-018-01420-8



As Cape Town water crisis deepens, scientists prepare for ‘Day Zero’ p.13

Researchers make plans to modify studies and prioritize public health as city reservoirs run dry.

doi: 10.1038/d41586-018-01134-x


Gender bias goes away when grant reviewers focus on the science p.14

But female scientists suffer when their research proposals are judged primarily on the strength of their CVs.

doi: 10.1038/d41586-018-01212-0


Israeli fossils are the oldest modern humans ever found outside of Africa p.15

Jaw and teeth mark Homo sapiens' early arrival on the Arabian Peninsula.

doi: 10.1038/d41586-018-01261-5


Anti-Darwin comments in India outrage scientists p.16

Researchers and government officials have condemned the statements of a junior minister who questioned the theory of evolution.

doi: 10.1038/d41586-018-01241-9


Unique oil spill in East China Sea frustrates scientists p.17

The lighter petroleum that spilled has never before been released in such massive quantities in the ocean.

doi: 10.1038/d41586-018-00976-9

News Features


How warp-speed evolution is transforming ecology p.19


doi: 10.1038/d41586-018-01400-y


Owls for peace: how conservation science is reaching across borders in the Middle East p.22


doi: 10.1038/d41586-018-01388-5

News & Views


Genomics: Regeneration writ large p.34

扁形動物のプラナリアSchmidtea mediterraneaとメキシコサンショウウオ(Ambystoma mexicanum)のゲノム塩基配列のアセンブリーから、この2種の生物の驚くべき再生特性に関する知見が得られた。

doi: 10.1038/d41586-017-09008-4


Breast cancer: A rude awakening from tumour cells p.35


doi: 10.1038/d41586-018-01140-z


Organic chemistry: Reactive carbon species tamed for synthesis p.36


doi: 10.1038/d41586-018-01308-7


Marine virology: A non-tailed twist in the viral tale p.38


doi: 10.1038/d41586-018-00923-8


Palaeoclimate: Pollen weighs in on a climate conundrum p.39


doi: 10.1038/d41586-018-00943-4



Enhancing the potential of enantioselective organocatalysis with light p.41

This Review discusses recent developments in the combination of organocatalysis and photochemistry for the activation of molecules, which has enabled previously inaccessible reaction pathways and influenced many fields of chemical research.

doi: 10.1038/nature25175



The axolotl genome and the evolution of key tissue formation regulators OPEN p.50

Sequencing and assembly of the 32-Gb genome of the Mexican axolotl reveals that it lacks the developmental gene Pax3, which is essential in other vertebrates; the genome sequence could improve our understanding of the evolution of the axolotl’s remarkable regenerative capabilities.

doi: 10.1038/nature25458


The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms OPEN p.56

An improved genome assembly for Schmidtea mediterranea shows that the genome is highly polymorphic and repetitive, and lacks multiple genes encoding core components of cell biological mechanisms.

doi: 10.1038/nature25473


Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes p.62

Oncogenic dosage variation along distinct evolutionary routes defines fundamental aspects of pancreatic cancer biology and phenotypic diversification.

doi: 10.1038/nature25459



Strong disk winds traced throughout outbursts in black-hole X-ray binaries p.69

Analysis of the light curves of outbursts in black-hole X-ray binaries suggests that throughout the accretion process mass is lost from the accretion disks through strong, magnetically driven disk winds.

doi: 10.1038/nature25159


A large oxygen-dominated core from the seismic cartography of a pulsating white dwarf p.73

Asteroseismic ‘sounding’ reveals the internal chemical stratification of the white dwarf KIC08626021, which has a central homogeneous core—composed of 86 per cent oxygen—that has a mass of 0.45 solar masses.

doi: 10.1038/nature25136


Centimetre-scale electron diffusion in photoactive organic heterostructures p.77

For a suitably designed organic multilayer structure, optically or electrically generated electrons confined to a thin fullerene channel can diffuse over surprisingly long distances of several centimetres.

doi: 10.1038/nature25148


Small-scale soft-bodied robot with multimodal locomotion p.81

A tiny soft-bodied robot is described that can be magnetically actuated to swim, climb, roll, walk and jump, while carrying a load.

doi: 10.1038/nature25443


Generating carbyne equivalents with photoredox catalysis p.86

A photocatalytic strategy is described that generates diazomethyl radicals as direct equivalents of carbynes, which are often too reactive to use, enabling the functionalization of a range of medically useful compounds.

doi: 10.1038/nature25185


Reconciling divergent trends and millennial variations in Holocene temperatures p.92

Analysis of pollen records from North America and Europe reveals a warming trend over the Holocene, consistent with climate-model simulations.

doi: 10.1038/nature25464


Early Middle Palaeolithic culture in India around 385–172 ka reframes Out of Africa models p.97

Lithic assemblages from the archaeological site of Attirampakkam, India, document processes of transition from Acheulian to Middle Palaeolithic cultures and substantial behavioural changes around 385,000 years ago and thereafter.

doi: 10.1038/nature25444


The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation p.102

A newly designed honeycomb maze presents several advantages over current spatial navigation assays that include greater control over the rat’s choices throughout the task and the collection of electrophysiological data during navigation.

doi: 10.1038/nature25433


Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells p.106

Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

doi: 10.1038/nature25455


Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders p.112

Mutations associated with Treacher Collins syndrome perturb the subnuclear localization of an RNA helicase involved in ribosome biogenesis through activation of p53 protein, illustrating how disruption in general regulators that compromise nucleolar homeostasis can result in tissue-selective malformations.

doi: 10.1038/nature25449


A major lineage of non-tailed dsDNA viruses as unrecognized killers of marine bacteria p.118

Members of a family of marine dsDNA non-tailed bacterial viruses have short, 10-kb genomes, infect a broader range of hosts than tailed viruses and belong to the double jelly roll capsid lineage of viruses, which are associated with diverse bacterial and archaeal hosts.

doi: 10.1038/nature25474


Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation p.123

A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level.

doi: 10.1038/nature25434


Mitochondrial translation requires folate-dependent tRNA methylation p.128

Mammalian mitochondria use folate-bound one-carbon units generated by the enzyme SHMT2 to methylate tRNA, and this modification is required for mitochondrial translation and thus oxidative phosphorylation.

doi: 10.1038/nature25460

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