Volume 561 Number 7721



Molecular test of age highlights difficult questions p.5

From forensics to sporting events, disputed age is a source of tension.

doi: 10.1038/d41586-018-06165-y


Global warming tops the agenda as climate brings down a third Australian prime minister p.5

Malcolm Turnbull is merely the latest leader to discover that action on emissions remains a difficult step to take.

doi: 10.1038/d41586-018-06164-z


The landmark lectures of physicist Erwin Schrödinger helped to change attitudes in biology p.6

Influence of his book ‘What is Life?’ celebrated and discussed 75 years on.

doi: 10.1038/d41586-018-06166-x



Mining and dams exacerbated devastating Kerala floods p.13

Scientists say a boom in development in the Western Ghats mountains contributed to the disaster that has killed almost 500 people.

doi: 10.1038/d41586-018-06145-2


Experimental Ebola drugs face tough test in war zone p.14

Researchers are devising a clinical-trial protocol to test three medicines in Africa’s latest outbreak.

doi: 10.1038/d41586-018-06132-7


European scientists seek ‘epigenetic clock’ to determine age of refugees p.15

They say that a more accurate test could help to implement laws that protect minors seeking asylum.

doi: 10.1038/d41586-018-06121-w


World Bank pours hundreds of millions into African science p.16

Huge grassroots initiative has founded dozens of research centres across the continent — but the hubs face an uncertain future.

doi: 10.1038/d41586-018-06094-w


Enormous wildfires spark scramble to improve fire models p.16

Blazes in North America are becoming larger and more powerful.

doi: 10.1038/d41586-018-06090-0


Radical open-access plan could spell end to journal subscriptions p.17

Eleven research funders in Europe announce ‘Plan S’ to make all scientific works free to read as soon as they are published.

doi: 10.1038/d41586-018-06178-7

News Features


A murdered teen, two million tweets and an experiment to fight gun violence p.20


doi: 10.1038/d41586-018-06169-8


The quest to conquer Earth’s space junk problem p.24


doi: 10.1038/d41586-018-06170-1

News & Views


Planetary science: Jupiter’s magnetic field revealed by the Juno spacecraft p.36


doi: 10.1038/d41586-018-06095-9


Immunology: An immune response with a sweet tooth p.37


doi: 10.1038/d41586-018-05854-y


Chemical biology: DNA tags used to image sugar-bearing proteins on cells p.38


doi: 10.1038/d41586-018-06092-y


Ecology: An alternative to controversial pesticides still harms bumblebees p.40


doi: 10.1038/d41586-018-05917-0


Structural biology: Spotlight on proteins that aid malaria p.41


doi: 10.1038/d41586-018-05977-2


Quantum physics: Designer atom arrays for quantum computing p.43


doi: 10.1038/d41586-018-06107-8



Facing up to the global challenges of ageing p.45

Longer human lives have led to a global burden of late-life disease, and so interventions, including changes to lifestyle and medical innovations, are needed to prevent disease and increase late-life health.

doi: 10.1038/s41586-018-0457-8



Integrating time from experience in the lateral entorhinal cortex p.57

Temporal information that is useful for episodic memory is encoded across a wide range of timescales in the lateral entorhinal cortex, arising inherently from its representation of ongoing experience.

doi: 10.1038/s41586-018-0459-6


Role of glutamine synthetase in angiogenesis beyond glutamine synthesis p.63

The enzyme glutamine synthetase is active in endothelial cell migration during angiogenesis, through autopalmitoylation and the regulation of RHOJ signalling.

doi: 10.1038/s41586-018-0466-7


Malaria parasite translocon structure and mechanism of effector export p.70

Cryo-electron microscopy analysis of the purified Plasmodium translocon of exported proteins (PTEX) reveals two distinct resolved states, suggesting a mechanism by which Plasmodium falciparum exports malarial effector proteins into erythrocytes.

doi: 10.1038/s41586-018-0469-4



A complex dynamo inferred from the hemispheric dichotomy of Jupiter’s magnetic field p.76

Maps of Jupiter’s internal magnetic field at a range of depths reveal an unusual morphology, suggesting that Jupiter’s dynamo, unlike Earth’s, does not operate in a thick, homogeneous shell.

doi: 10.1038/s41586-018-0468-5


Synthetic three-dimensional atomic structures assembled atom by atom p.79

Arbitrarily shaped, defect-free three-dimensional synthetic structures with up to 72 individually controlled atoms are assembled using holographic methods and moving tweezers.

doi: 10.1038/s41586-018-0450-2


Sorting ultracold atoms in a three-dimensional optical lattice in a realization of Maxwell’s demon p.83

An experiment inspired by Maxwell’s ‘demon’ thought experiment uses a series of reversible operations to fully fill a three-dimensional optical lattice with ultracold atoms and realize a low-entropy state.

doi: 10.1038/s41586-018-0458-7


All-inorganic perovskite nanocrystal scintillators p.88

All-inorganic perovskite nanocrystals containing caesium and lead provide low-cost, flexible and solution-processable scintillators that are highly sensitive to X-ray irradiation and emit radioluminescence that is colour-tunable across the visible spectrum.

doi: 10.1038/s41586-018-0451-1


A Brownian quasi-crystal of pre-assembled colloidal Penrose tiles p.94

A lithographic patterning and release method is used to create a dense, fluctuating, Brownian system of mobile colloidal kite- and dart-shaped Penrose tiles over large areas that retains quasi-crystalline order.

doi: 10.1038/s41586-018-0464-9


Climate-induced changes in continental-scale soil macroporosity may intensify water cycle p.100

Soil macroporosity responds rapidly to climate variations and may induce wide-ranging changes in soil hydraulic conductivity by the end of the century.

doi: 10.1038/s41586-018-0463-x


Jurassic stem-mammal perinates and the origin of mammalian reproduction and growth p.104

A well-preserved clutch of Kayentatherium wellesi perinates sheds light on the timing of the evolution of mammalian traits, including reduced clutch sizes and the allometric lengthening of the face during ontogeny.

doi: 10.1038/s41586-018-0441-3


Sulfoxaflor exposure reduces bumblebee reproductive success p.109

Chronic exposure to sulfoxaflor (a sulfoximine-based insecticide) has severe sub-lethal effects on bumblebee (Bombus terrestris) colonies; exposed colonies produced fewer workers and fewer reproductive offspring than unexposed control colonies.

doi: 10.1038/s41586-018-0430-6


The genome of the offspring of a Neanderthal mother and a Denisovan father p.113

Genomic evidence of the offspring of a Neanderthal mother and a Denisovan father suggests that mixing among different hominin groups may have more been frequent than previously appreciated.

doi: 10.1038/s41586-018-0455-x


Past experience shapes sexually dimorphic neuronal wiring through monoaminergic signalling p.117

In Caenorhabditis elegans, starvation early in life suppresses later sex-specific pruning of synapses through lasting changes in monoaminergic signalling.

doi: 10.1038/s41586-018-0452-0


Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose p.122

The bacterial metabolite ADP-heptose activates NF-κB in host cells via alpha-kinase 1 and the TIFA–TRAF signalling pathway.

doi: 10.1038/s41586-018-0433-3


Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia p.127

The inactivation of tumour suppressor genes at the level of mRNA occurs by the generation of truncated proteins in leukaemia.

doi: 10.1038/s41586-018-0465-8

分子生物学:NORAD lncRNAはゲノム安定性に重要なトポイソメラーゼ複合体を組み立てる

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability p.132

The long non-coding RNA NORAD interacts with proteins involved in DNA replication and repair, and controls the ability of RBMX to form a ribonucleoprotein complex that helps to maintain genomic stability.

doi: 10.1038/s41586-018-0453-z


Structures of filaments from Pick’s disease reveal a novel tau protein fold p.137

The structures of tau filaments from patients with the neurodegenerative disorder Pick’s disease show that the filament fold is different from that of the tau filaments found in Alzheimer’s disease.

doi: 10.1038/s41586-018-0454-y

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