Cross-hatched crayon on a rock shard suggests early humans indulged in abstract art.
doi: 10.1038/d41586-018-06657-x
An algebra pioneer who faced discrimination deserves wider recognition on the centenary of her namesake theorem.
doi: 10.1038/d41586-018-06658-w
Imran Khan’s new administration must respect expertise to meet its ambitious goals.
doi: 10.1038/d41586-018-06659-9
Blazes have created natural experiments in Montana and California towns and a monkey-breeding colony.
doi: 10.1038/d41586-018-06123-8
Sweeping policy changes aim to refocus research efforts on poverty, unemployment, drought and other national problems.
doi: 10.1038/d41586-018-06122-9
But experts say the mission is a huge task and could detract from more useful space programmes.
doi: 10.1038/d41586-018-06146-1
Astrophysicist plans to spend prize money — awarded 50 years after the discovery — on increasing diversity in science.
doi: 10.1038/d41586-018-06210-w
The tool, called Google Dataset Search, should help researchers to find the data they need more easily.
doi: 10.1038/d41586-018-06201-x
データセンターでは、取り扱うデータ量の急激な増加に伴い莫大なエネルギーが消費されており、これを少しでも減らそうと効率化を目指した研究が進んでいる。
doi: 10.1038/d41586-018-06610-y
骨芽細胞と呼ばれる骨を形成する細胞によって放出されるRANKLタンパク質は、破骨細胞上のその受容体RANKと結合して骨吸収の引き金を引く。今回、この経路が逆にも作用して骨形成を促進することが明らかになった。
doi: 10.1038/d41586-018-05960-x
スピントロニクスと呼ばれるエレクトニクスの一種では、電子スピンの制御された長距離輸送が必要である。今回、最も一般的な種類の磁性材料である反強磁性体で、そうした輸送が実現された。
doi: 10.1038/d41586-018-06197-4
胚では、上皮と呼ばれる細胞のシートが湾曲して管になることがある。今回、モデル化とin vivo観察によって、これまでのいくつかの仮説に反して、管の細胞がscutoidと名付けられた非対称な細胞形状をとることが明らかになった。
doi: 10.1038/d41586-018-06162-1
今回コンピューターシミュレーションによって、海水準上昇に起因する干潟の喪失は、新たに海に沈んだ地域における干潟生態系の陸側への拡大によって、大きく相殺される可能性が示唆された。
doi: 10.1038/d41586-018-06190-x
PINK1タンパク質とparkinタンパク質は、損傷したミトコンドリアの分解を助けており、こうしたタンパク質の異常がパーキンソン病と関連付けられている。今回マウス研究によって、これらのタンパク質が炎症を防ぐように作用することが明らかになった。
doi: 10.1038/d41586-018-05988-z
今回、酵母細胞のタンパク質複合体の大半が、サブユニットが完全に形成される前に集合することが分かった。この機構は、有害なタンパク質凝集体の形成を妨げている可能性がある。
doi: 10.1038/d41586-018-05905-4
Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.
doi: 10.1038/s41586-018-0483-6
Osteoclasts secrete small extracellular vesicles that stimulate osteoblasts, promoting bone formation via receptor activator of nuclear factor-kappa B ligand (RANKL), thereby linking bone formation and resorption.
doi: 10.1038/s41586-018-0482-7
Comparison of multiple lesions from individual pancreases sheds light on how ancestral clones can spread through the ductal system and give rise to precursor lesions, with acquisition of further mutations leading to pancreatic cancer.
doi: 10.1038/s41586-018-0481-8
Observations of a hot flow anomaly accelerating solar-wind ions suggest a mechanism for such acceleration—a Fermi acceleration trap caused by Earth’s bow shock interacting with the solar wind.
doi: 10.1038/s41586-018-0472-9
The observation of the 1S–2P Lyman-α transition in the antihydrogen atom, the antimatter counterpart of hydrogen, is reported.
doi: 10.1038/s41586-018-0435-1
Rates of radiative heat transfer between sub-wavelength planar membranes are experimentally and theoretically shown to exceed the blackbody limit in the far field by more than two orders of magnitude.
doi: 10.1038/s41586-018-0480-9
Tunable spin transport over long distances is demonstrated through the antiferromagnetic insulator haematite, paving the way to the development of spin-logic devices based on antiferromagnetic insulators.
doi: 10.1038/s41586-018-0490-7
3D printing of liquid-crystal polymers can create lightweight hierarchical structures with very high stiffness and toughness.
doi: 10.1038/s41586-018-0474-7
A global modelling approach shows that in response to rises in global sea level, gains of up to 60% in coastal wetland areas are possible, if appropriate coastal management solutions are developed to help support wetland resilience.
doi: 10.1038/s41586-018-0476-5
Meristems of the rooting axes of Asteroxylon mackiei preserved in 407-million-year-old Rhynie chert lack root caps, which demonstrates that the evolution of the root systems of modern vascular plants occurred in a stepwise fashion.
doi: 10.1038/s41586-018-0445-z
Tools are embodied by the human somatosensory system, serving as sensory extensions of the human body.
doi: 10.1038/s41586-018-0460-0
Four transcription factors that specify keratinocyte cell fate, facilitate in vivo reprogramming of wound-resident mesenchymal cells, epithealization and regeneration of skin epithelial tissues in mice.
doi: 10.1038/s41586-018-0477-4
The plant receptor kinase co-receptor BAK1 contains phosphosites that are required for immune function but not for brassinosteroid-regulated growth in Arabidopsis thaliana; an additional tyrosine phosphosite may be required for the function of many Arabidopsis receptor kinases.
doi: 10.1038/s41586-018-0471-x
Integrative analyses identify host proteins that are modulated by Zika virus at multiple levels and provide a comprehensive framework for the understanding of Zika virus-induced changes to cellular pathways.
doi: 10.1038/s41586-018-0484-5
Acute and chronic mitochondrial stress in mice require PINK1 and parkin to restrain STING-mediated innate immunity.
doi: 10.1038/s41586-018-0448-9
During starvation, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) targets GTPase-activating proteins to inhibit multiple intracellular transport pathways, thereby promoting energy homeostasis.
doi: 10.1038/s41586-018-0475-6
Cotranslational assembly is a prevalent mechanism for the formation of oligomeric complexes in Saccharomyces cerevisiae, with one subunit serving as scaffold for the translation of partner subunits.
doi: 10.1038/s41586-018-0462-y
