ヒトの全ての主要な組織における遺伝子発現と調節を調べるGTEx(Genotype-Tissue Expression)プロジェクトの長年の努力が、実を結んだ。

A more personal view p.157

Long-planned genetic catalogue probes gene regulation.

doi: 10.1038/550157a

Full Text


Climate meetings pose serious test in the Trump era p.158

Annual jamborees fail to ignite public passion but are crucial to progress on global-warming.

doi: 10.1038/550158a

Full Text


Marine snow falls heaviest at the Equator p.158

Organic matter drifts down to the equatorial ocean floor in distinct patterns.

doi: 10.1038/550158b

Full Text



Navajo Nation reconsiders ban on genetic research p.165

Tribal leaders are developing a policy for genetic research and data sharing, potentially ending a 15-year moratorium.

doi: 10.1038/nature.2017.22780

Full Text


Scientists plead with Brazilian government to restore funding p.166

If officials don't act soon, research institutions could start shutting down next year.

doi: 10.1038/nature.2017.22757

Full Text


Cryo-electron microscopy wins chemistry Nobel p.167

Jacques Dubochet, Joachim Frank and Richard Henderson share the prize for developing a technique to image biomolecules.

doi: 10.1038/nature.2017.22738

Full Text


The ambitious effort to document California’s changing deserts p.168

Ecologists catalogue bird and mammal populations as warming transforms Death Valley.

doi: 10.1038/550168a

Full Text


Gene-expression study raises thorny ethical issues p.169

Project obtains tissues from recently deceased individuals to look for the origins of disease.

doi: 10.1038/550169a

Full Text

News Features

環境: 冷戦の遺産をガラスの中に

How the United States plans to trap its biggest stash of nuclear-weapons waste in glass p.172


doi: 10.1038/550172a

Full Text

ゲノミクス: 復活を遂げた23andMe社

The rise and fall and rise again of 23andMe p.174

Anne Wojcickiが起業した遺伝子検査会社23andMeの、立ち上げから、深刻な危機を経て、再び科学的に脚光を浴びるようになるまでをたどる。

doi: 10.1038/550174a

Full Text

News & Views

ヒトゲノミクス: 調節コードの解読

Human genomics: Cracking the regulatory code p.190


doi: 10.1038/550190a

Full Text | PDF

数学: パライアの居場所

Mathematics: A pariah finds a home p.191


doi: 10.1038/nature24147

Full Text | PDF

がん: 薬剤依存性の腫瘍は脆弱である

Cancer: Tumours addicted to drugs are vulnerable p.192


doi: 10.1038/nature24148

Full Text | PDF

工学: これまでで最高の温度で液体金属を押し出すポンプ

Engineering: Liquid metal pumped at a record temperature p.194


doi: 10.1038/550194b

Full Text | PDF

肥満: 体重を調節する受容体が特定された

Obesity: Receptors identified for a weight regulator p.195


doi: 10.1038/nature24143

Full Text | PDF

天文学: 準惑星を巡る環が見つかった

Astronomy: Ring detected around a dwarf planet p.197


doi: 10.1038/550197a

Full Text | PDF


工学: 最高1673 Kの高温液体金属をポンプ輸送する

Pumping liquid metal at high temperatures up to 1,673 kelvin p.199

By using ceramics for the mechanical and sealing components of a mechanical pump, liquid metal can be circulated continuously at temperatures at least as high as 1,673 kelvin.

doi: 10.1038/nature24054

日本語要約 | Full Text | PDF

ゲノミクス: ヒトの多数の組織にわたる遺伝子発現への遺伝的影響

Genetic effects on gene expression across human tissues OPEN p.204

Samples of different body regions from hundreds of human donors are used to study how genetic variation influences gene expression levels in 44 disease-relevant tissues.

doi: 10.1038/nature24277

日本語要約 | Full Text | PDF

分子生物学: 転写忠実度因子GreAはDNA切断修復を遅らせる

The transcription fidelity factor GreA impedes DNA break repair p.214

In Escherichia coli, the control of RNA polymerase backtracking by transcription elongation factors impairs DNA break repair by affecting RecBCD resection and consequently RecA loading at sites far removed from the original DNA break.

doi: 10.1038/nature23907

日本語要約 | Full Text | PDF


天文学: 星の掩蔽から求められた準惑星ハウメアのサイズ、形状、密度、環

The size, shape, density and ring of the dwarf planet Haumea from a stellar occultation p.219

Observations of a stellar occultation of Haumea, one of the four known trans-Neptunian dwarf planets, constrain its size, shape and density, and reveal a ring coplanar with Haumea’s largest moon.

doi: 10.1038/nature24051

日本語要約 | Full Text | PDF

フォトニクス: グラフェンにおける光場駆動電流

Light-field-driven currents in graphene p.224

Light-field-driven control of electrons in a conductor is demonstrated by inducing a current by laser pulses in graphene that is sensitive to the carrier-envelope phase.

doi: 10.1038/nature23900

日本語要約 | Full Text | PDF

ナノスケール材料: 二次元材料の交互積層によるウエハースケールのヘテロ構造体の形成

Layer-by-layer assembly of two-dimensional materials into wafer-scale heterostructures p.229

Layer-by-layer stacking enables the construction of transition-metal dichalcogenide van der Waals heterostructures with high-quality, uniform interfaces and tunable electrical properties.

doi: 10.1038/nature23905

日本語要約 | Full Text | PDF

材料科学: コロイド融合によって作製したパッチ粒子

Patchy particles made by colloidal fusion p.234

By exploiting geometric constraints and interfacial forces instead of chemistry, colloidal clusters can be controllably coalesced into particles with uniformly distributed surface patches.

doi: 10.1038/nature23901

日本語要約 | Full Text | PDF

ゲノミクス: まれな変異が多数の組織にわたって遺伝子発現に及ぼす影響

The impact of rare variation on gene expression across tissues OPEN p.239

The authors show that rare genetic variants contribute to large gene expression changes across diverse human tissues and provide an integrative method for interpretation of rare variants in individual genomes.

doi: 10.1038/nature24267

日本語要約 | Full Text | PDF

ゲノミクス: 多数のヒト組織におけるX染色体不活性化の全体像

Landscape of X chromosome inactivation across human tissues OPEN p.244

Multiple transcriptome approaches, including single-cell sequencing, demonstrate that escape from X chromosome inactivation is widespread and occasionally variable between cells, chromosomes, and tissues, resulting in sex-biased expression of at least 60 genes and potentially contributing to sex-specific differences in health and disease.

doi: 10.1038/nature24265

日本語要約 | Full Text | PDF

ゲノミクス: 哺乳類におけるRNA編集の動的な状況と調節

Dynamic landscape and regulation of RNA editing in mammals p.249

Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

doi: 10.1038/nature24041

日本語要約 | Full Text | PDF

代謝: 脳幹だけに存在するGDF15受容体を介して起こる非恒常的体重調節

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15 p.255

GDNF receptor alpha-like is a brainstem-restricted receptor for growth and differentiation factor 15, regulating appetite and body weight in non-homeostatic conditions by activating the emergency circuit response to disease and toxin stresses.

doi: 10.1038/nature24042

日本語要約 | Full Text | PDF

心血管疾患: Hippo経路の欠失は心筋梗塞後の収縮期心不全を回復させる

Hippo pathway deficiency reverses systolic heart failure after infarction p.260

Deletion of the Hippo pathway component Salvador in mouse hearts with established ischaemic heart failure after myocardial infarction induces a reparative genetic program with increased scar border vascularity, reduced fibrosis, and recovery of pumping function.

doi: 10.1038/nature24045

日本語要約 | Full Text | PDF

生化学: TOROIDがTORC1の活性を調節する

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity p.265

In budding yeast, glucose withdrawal, via the Rag GTPases, leads to TORC1 inhibition through its re-organization into a giant, vacuole-associated helix named a TOROID (TORC1 organized in inhibited domain).

doi: 10.1038/nature24021

日本語要約 | Full Text | PDF

がん: がんの薬剤依存性には、ERK2に依存した表現型転換が介在している

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch p.270

The identification of an ERK2–JUNB–FRA1 signalling pathway that drives addiction to therapeutic drugs in cancer cells, and an ERK2-dependent phenotype switch that precedes cell death after drug withdrawal, may help to guide therapies that exploit the addiction phenotype.

doi: 10.1038/nature24037

日本語要約 | Full Text | PDF

分子生物学: ウイルスのSmクラスRNAはmRNAと塩基対を形成し、さらにマイクロRNAを動員してアポトーシスを阻害する

A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis p.275

Herpesvirus saimiri expresses a small nuclear RNA named HSUR2, with which it recruits two cellular microRNAs to repress specific mRNA targets and thereby inhibit apoptosis in infected T cells.

doi: 10.1038/nature24034

日本語要約 | Full Text | PDF

生物工学: CRISPR–Cas13によるRNAの標的化

RNA targeting with CRISPR–Cas13 p.280

The class 2 type VI RNA-guided RNA-targeting CRISPR–Cas effector Cas13 can be engineered for RNA knockdown and binding, expanding the CRISPR toolset with a flexible platform for studying RNA in mammalian cells and therapeutic development.

doi: 10.1038/nature24049

日本語要約 | Full Text | PDF

「Journal home」に戻る