Volume 555 Number 7698



On the use and abuse of ancient DNA p.559

Researchers in several disciplines need to tread carefully over shared landscapes of the past.

doi: 10.1038/d41586-018-03857-3


Cambridge Analytica controversy must spur researchers to update data ethics p.559

A scandal over an academic’s use of Facebook data highlights the need for research scrutiny.

doi: 10.1038/d41586-018-03856-4

米国のSONIC Drive-In社が発売する牛肉とキノコのブレンド・ハンバーガーは、健康と環境問題の両方に効果があるかもしれない。

Mushrooms: coming soon to a burger near you p.560

Mushroom–beef blends can tackle expanding waistlines and carbon footprints.

doi: 10.1038/d41586-018-03855-5



Pioneering Alzheimer’s study in Colombia zeroes in on enigmatic protein p.567

Researchers tracking a genetic mutation that causes an early-onset form of the disease hope to uncover new drug targets.

doi: 10.1038/d41586-018-03848-4


Four-in-one 3D printer paves way for custom-made robots and phones p.569

Experimental device is a route to printing smartphones and other electronics.

doi: 10.1038/d41586-018-03446-4


Ocean scientists work to forecast huge plankton blooms in Arabian Sea p.569

An operational forecast could help countries prepare for booms in these tiny marine creatures.

doi: 10.1038/d41586-018-03698-0


Reduced-calorie diet shows signs of slowing ageing in people p.570

Most comprehensive study yet demonstrates that cutting people’s energy intake turns down their metabolism.

doi: 10.1038/d41586-018-03431-x


First space mission dedicated to exoplanet atmospheres gets green light p.571

Scientists hope to learn what makes a ‘typical’ solar system from the European Space Agency’s €450-million probe.

doi: 10.1038/d41586-018-03445-5


US science agencies set to win big in budget deal p.572

Lawmakers are set to vote this week on legislation that includes significant funding increases for many science agencies.

doi: 10.1038/d41586-018-03700-9

News Features


Divided by DNA: The uneasy relationship between archaeology and ancient genomics p.573


doi: 10.1038/d41586-018-03773-6

News & Views


Sensory systems: A trio of ion channels takes the heat p.591


doi: 10.1038/d41586-018-02663-1


Planetary science: Oceans on Mars formed early p.592


doi: 10.1038/d41586-018-03415-x


Chemistry: AI designs organic syntheses p.592


doi: 10.1038/d41586-018-03774-5


Materials science: Wing origami p.594


doi: 10.1038/d41586-018-03775-4


Immunology: Killer T cells show their kinder side p.594


doi: 10.1038/d41586-018-03510-z


Metabolism: The healthy diabetic cavefish conundrum p.595


doi: 10.1038/d41586-018-03242-0


Cardiology: The tornadoes of sudden cardiac arrest p.597


doi: 10.1038/d41586-018-01950-1



A coherent spin–photon interface in silicon p.599

A single spin in silicon is strongly coupled to a microwave-frequency photon and coherent single-spin dynamics are observed using circuit quantum electrodynamics.

doi: 10.1038/nature25769


Planning chemical syntheses with deep neural networks and symbolic AI p.604

Deep neural networks and Monte Carlo tree search can plan chemical syntheses by training models on a huge database of published reactions; their predicted synthetic routes cannot be distinguished from those a human chemist would design.

doi: 10.1038/nature25978

遺伝学:神経発達障害における調節エレメントのde novo変異

De novo mutations in regulatory elements in neurodevelopmental disorders p.611

Analysis of rare de novo mutations in gene regulatory elements suggests that 1–3% of patients with neurodevelopmental disorders carry such mutations in elements that are active in the fetal brain.

doi: 10.1038/nature25983


Encoding of danger by parabrachial CGRP neurons p.617

Single-cell recordings show that CGRP-expressing neurons in the parabrachial nucleus in mice respond to both noxious stimuli and signals of feeding satiety.

doi: 10.1038/nature25511


Extensive impact of non-antibiotic drugs on human gut bacteria p.623

A screen of more than 1,000 drugs shows that about a quarter of the non-antibiotic drugs inhibit the growth of at least one commensal bacterial strain in vitro.

doi: 10.1038/nature25979



A galaxy lacking dark matter p.629

Galaxies normally have far more dark matter than normal matter, but the dynamics of objects within the ultra-diffuse galaxy NGC1052–DF2 suggest that it has a very little dark matter component.

doi: 10.1038/nature25767


A programmable two-qubit quantum processor in silicon p.633

A two-qubit quantum processor in a silicon device is demonstrated, which can perform the Deutsch–Josza algorithm and the Grover search algorithm.

doi: 10.1038/nature25766


Massive Dirac fermions in a ferromagnetic kagome metal p.638

Fe3Sn2 hosts massive Dirac fermions, owing to the underlying symmetry properties of the bilayer kagome lattice in the ferromagnetic state and the atomic spin–orbit coupling.

doi: 10.1038/nature25987


Timing of oceans on Mars from shoreline deformation p.643

Ancient shorelines on Mars must have formed before and during the emplacement of the Tharsis volcanic province, instead of afterwards as previously assumed, suggesting that oceans on Mars formed early.

doi: 10.1038/nature26144


Insulin resistance in cavefish as an adaptation to a nutrient-limited environment p.647

Cavefish populations of the Mexican tetra, Astyanax mexicanus, carry a mutation in the insulin receptor gene that renders them insulin- and starvation-resistant relative to surface populations of the same species.

doi: 10.1038/nature26136


Reconstructing the genetic history of late Neanderthals p.652

Genetic similarity among late Neanderthals is predicted well by their geographical location, and although some of these Neanderthals were contemporaneous with early modern humans, their genomes show no evidence of recent gene flow from modern humans.

doi: 10.1038/nature26151


Moving magnetoencephalography towards real-world applications with a wearable system p.657

A new magnetoencephalography system allows high-spatiotemporal-resolution imaging of human brain function in moving subjects.

doi: 10.1038/nature26147


A TRP channel trio mediates acute noxious heat sensing p.662

Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, whereas double-knockout mice do not.

doi: 10.1038/nature26137


Electromechanical vortex filaments during cardiac fibrillation p.667

Using optical mapping and 3D ultrasound, the dynamics and interactions between electrical and mechanical phase singularities were analysed by simultaneously measuring the membrane potential, intracellular calcium concentration and mechanical contractions of the heart during normal rhythm and fibrillation.

doi: 10.1038/nature26001


Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance p.673

Hepatocytes secrete DPP4, which promotes adipose tissue inflammation and insulin resistance in obese mice, suggesting a new specific target for treatment of metabolic disorders.

doi: 10.1038/nature26138


The protein histidine phosphatase LHPP is a tumour suppressor p.678

Decreased expression of histidine phosphatase LHPP, a novel tumour suppressor, results in increased global histidine phosphorylation and hepatocellular carcinoma.

doi: 10.1038/nature26140


Optogenetic regulation of engineered cellular metabolism for microbial chemical production p.683

Finely tuned optogenetic control of engineered Saccharomyces cerevisiae enhances the biosynthesis of valuable products such as isobutanol in laboratory-scale fermenters.

doi: 10.1038/nature26141

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