Volume 547 Number 7664



More universities must confront sexual harassment p.379

Too many institutions give low priority to tackling sexual misconduct in science.

doi: 10.1038/547379a


Put cult online games to the test p.379

There are now vast opportunities to study the effects on young minds.

doi: 10.1038/547379b


The digital native is a myth p.380

The younger generation uses technology in the same ways as older people — and is no better at multitasking.

doi: 10.1038/547380a



Iceland drilling project aims to unearth how islands form p.387

Scientists will look into the heart of Surtsey, an island created 50 years ago by a volcanic eruption.

doi: 10.1038/nature.2017.22340


US defence agencies grapple with gene drives p.388

National security community examines the risks and benefits of technology to quickly spread genetic modifications.

doi: 10.1038/nature.2017.22345


Brain’s stem cells slow ageing in mice p.389

Transplanted cells offer middle-aged rodents an increased lifespan.

doi: 10.1038/547389a

英国では、技術革新と研究成果の商業化を支援推進する資金配分機関「Innovate UK」の存在感がますます大きく。

Budding UK innovation agency gains cash — and clout p.390

Business-focused funding agency Innovate UK is driving British efforts to commercialize research.

doi: 10.1038/547390a


Giant radio telescope scaled back to contain costs p.391

Crowding antennas closer together may affect the Square Kilometre Array's ability to observe the early Universe.

doi: 10.1038/nature.2017.22361

News Features


China’s quest to become a space science superpower p.394


doi: 10.1038/547394a

News & Views


Biomechanics: How fish feel the flow p.406


doi: 10.1038/nature23096


Applied physics: A new spin on nanoscale computing p.407


doi: 10.1038/547407a


Neurobiology: Synapses get together for vision p.408


doi: 10.1038/nature23098


Organic chemistry: Molecular structure assignment simplified p.410


doi: 10.1038/547410a


Global health: Towards polio eradication p.411


doi: 10.1038/547411a


腫瘍免疫学:in vivoでのCRISPRスクリーニングにより明らかになったがん免疫療法の標的としてのPtpn2

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target p.413

In vivo CRISPR screening reveals that loss of Ptpn2 increases the response of tumour cells to immunotherapy and increases IFNγ signalling, suggesting that PTPN2 inhibition may potentiate the effect of immunotherapies that invoke an IFNγ response.

doi: 10.1038/nature23270


Maternal H3K27me3 controls DNA methylation-independent imprinting p.419

Analysis of parental allele-specific chromatin accessibility genome-wide in mouse zygotes and morula embryos, and investigation of the epigenetic mechanisms underlying these allelic sites, identifying maternal H3K27me3 as a DNA methylation-independent mechanism for genomic imprinting.

doi: 10.1038/nature23262


天文学:GRB 160625Bの即時可視閃光の間に顕著に変動する直線偏光

Significant and variable linear polarization during the prompt optical flash of GRB 160625B p.425

The prompt optical flash produced by the γ-ray burst GRB 160625B is highly linearly polarized, suggesting that it is produced by fast-cooling synchrotron radiation in a large-scale magnetic field.

doi: 10.1038/nature23289


Neuromorphic computing with nanoscale spintronic oscillators p.428

Spoken-digit recognition using a nanoscale spintronic oscillator that mimics the behaviour of neurons demonstrates the potential of such oscillators for realizing large-scale neural networks in future hardware.

doi: 10.1038/nature23011


Spontaneous breaking of rotational symmetry in copper oxide superconductors p.432

The electronic nematic phase in copper oxide superconductors is found over a broad range of temperature and doping but is not aligned with the crystal axes.

doi: 10.1038/nature23290


Synergy of synthesis, computation and NMR reveals correct baulamycin structures p.436

Experimental and computed nuclear magnetic resonance data and an iterative synthetic strategy have revealed the correct structures of the baulamycins, potentially important antimicrobial compounds, allowing them to be chemically synthesized.

doi: 10.1038/nature23265


Global forest loss disproportionately erodes biodiversity in intact landscapes p.441

Deforestation increases the odds of a species being threatened by extinction, and this effect is disproportionately strong in relatively intact landscapes, suggesting that efforts are needed to protect intact forest landscapes and prevent a new wave of extinctions.

doi: 10.1038/nature23285


A novel mechanism for mechanosensory-based rheotaxis in larval zebrafish p.445

In the absence of visual information, larval zebrafish (Danio rerio) use their mechanosensory lateral line to perform rheotaxis by using flow velocity gradients as navigational cues.

doi: 10.1038/nature23014


Synaptic organization of visual space in primary visual cortex p.449

Mapping the organization of excitatory inputs onto the dendritic spines of individual mouse visual cortex neurons reveals how inputs representing features from the extended visual scene are organized and establishes a computational unit suited to amplify contours and elongated edges.

doi: 10.1038/nature23019


Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway p.453

Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid peroxidase pathways converging on GPX4.

doi: 10.1038/nature23007


Cysteine protease cathepsin B mediates radiation-induced bystander effects p.458

The cysteine protease CPR-4, a cathepsin B homologue, is identified as a radiation-induced bystander effect (RIBE) factor in nematodes in response to ultraviolet or ionizing radiation, and causes inhibition of cell death and increased embryonic lethality.

doi: 10.1038/nature23284


Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription p.463

Heterochromatin formation involves histone H3 methylation, with H3K9me2 defining a distinct heterochromatin state that is transcriptionally permissive and can couple with RNAi, and the transition to non-permissive H3K9me3 required for the epigenetic heritability of heterochromatin.

doi: 10.1038/nature23267


Crystal structures of agonist-bound human cannabinoid receptor CB1 p.468

Crystal structures of the human cannabinoid receptor 1 (CB1) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor activation, and this flexibility may be a common feature among other G-protein-coupled receptors.

doi: 10.1038/nature23272


The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture p.472

The lysosomal potassium channel TMEM175 has a tetrameric structure unlike that of the canonical potassium channels, with an hourglass-shaped pore in which isoleucine residues have a key role in channel selectivity.

doi: 10.1038/nature23269

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