Volume 548 Number 7665



Why antimatter might be the answer to life, the Universe and everything p.5

Experiments that reveal the behaviour of antihydrogen could tell physicists more about the rules that hold the Universe together.

doi: 10.1038/548005b


Seek climate advice through established routes p.5

If the Trump administration has questions on global warming, it should direct them to the national academy rather than setting up a spurious ‘red team–blue team’ debate.

doi: 10.1038/548005a



CRISPR fixes disease gene in viable human embryos p.13

Gene-editing experiment pushes scientific and ethical boundaries.

doi: 10.1038/nature.2017.22382


Jordan stakes its future on science p.14

The country wants to use a focus on research to solve its problems and build diplomatic ties in the Middle East.

doi: 10.1038/548014a


Fears rise for US climate report as Trump officials take reins p.15

Officials at the US Environmental Protection Agency are consulting global-warming sceptics as they weigh up a technical review.

doi: 10.1038/548015a


Big names in statistics want to shake up much-maligned P value p.16

One of scientists’ favourite statistics — the P value — should face tougher standards, say leading researchers.

doi: 10.1038/nature.2017.22375


Bacteria could be key to freeing South Pacific of mosquitoes p.17

Islands in the region could be rid of the biting insects within a decade.

doi: 10.1038/548017a

News Features


The race to reveal antimatter’s secrets p.20


doi: 10.1038/548020a

News & Views


Nuclear physics: The fastest-rotating fluid p.34


doi: 10.1038/548034a


Cognition: Neurons couple up to make decisions p.35


doi: 10.1038/nature23100


Metabolism: Energy sensing through a sugar diphosphate p.36

今回、グルコースの代謝時に生成されるフルクトース 1,6-ビスリン酸分子が、予想外の機構を通して、細胞がグルコース欠乏を感知するのを媒介していることが示された。

doi: 10.1038/nature23099


Ecology: Chimps at risk from anthrax p.38


doi: 10.1038/548038a


Astronomy: Ozone-like layer in an exoplanet atmosphere p.38


doi: 10.1038/548038b


Cancer: A precision approach to tumour treatment p.40

個別化治療法の使用の進歩により、in vitroin vivo療法の腫瘍モデルが作られた。このモデルは、がんの薬物療法の決定を助けるために、また、腫瘍がどのように治療に反応するかについての我々の理解を深めるために用いることができる可能性がある。

doi: 10.1038/nature23101



The evolution of the host microbiome as an ecosystem on a leash p.43

Within the human microbiome there is tension between microbes evolving to compete within the host ecosystem, and hosts trying to keep them under control.

doi: 10.1038/nature23292



Hypothalamic stem cells control ageing speed partly through exosomal miRNAs p.52

Ablation of hypothalamic stem/progenitor cells in mice leads to ageing-related decreases in physiological parameters and lifespan, and the speed of ageing is partially controlled by these cells through the release of exosomal miRNAs.

doi: 10.1038/nature23282



An ultrahot gas-giant exoplanet with a stratosphere p.58

Observations of the gas-giant exoplanet WASP-121b reveal near-infrared emission lines of water, suggesting that the planet has a stratosphere—a layer in the upper atmosphere where temperature increases with altitude.

doi: 10.1038/nature23266


Global Λ hyperon polarization in nuclear collisions p.62

The measurement of an alignment between the angular momentum of a non-central collision between heavy ions and the spin of emitted particles reveals that the fluid produced in the collision is extremely vortical.

doi: 10.1038/nature23004


Observation of the hyperfine spectrum of antihydrogen OPEN p.66

The hyperfine splitting of antihydrogen has been measured and is consistent with expectations for atomic hydrogen.

doi: 10.1038/nature23446


Quantum simulation of a Fermi–Hubbard model using a semiconductor quantum dot array p.70

A quantum simulation platform based on quantum dots is reported that can operate at relatively low temperatures, and its utility is shown by simulating a Fermi–Hubbard model.

doi: 10.1038/nature23022


Visible-light-driven methane formation from CO2 with a molecular iron catalyst p.74

An iron tetraphenylporphyrin complex is shown to catalyse the reduction of carbon dioxide to methane upon visible light irradiation at ambient temperature and pressure.

doi: 10.1038/nature23016


Elements of Eoarchean life trapped in mineral inclusions p.78

In situ infrared spectroscopy maps the occurrences of chemical bonds within tiny inclusions in 3,700-million-year-old metasedimentary rocks from West Greenland, finding greater evidence for organic life at this early date.

doi: 10.1038/nature23261


Persistent anthrax as a major driver of wildlife mortality in a tropical rainforest p.82

An anthrax-causing agent, Bacillus cereus biovar anthracis, is a persistent and widespread cause of death for a broad range of mammalian hosts in a tropical rainforest, with important implications for the conservation of mammals such as chimpanzees.

doi: 10.1038/nature23309

ゲノミクス:集団参照としての150人のデンマーク人ゲノムの塩基配列解読とde novoアセンブリ

Sequencing and de novo assembly of 150 genomes from Denmark as a population reference OPEN p.87

A report of high-depth, short-read sequencing and de novo assemblies for 150 individuals from 50 parent–offspring trios as part of establishing a population reference genome for the GenomeDenmark project.

doi: 10.1038/nature23264


Distinct timescales of population coding across cortex p.92

Calcium imaging data from mice performing a virtual reality auditory decision-making task are used to analyse the population codes in primary auditory and posterior parietal cortex that support choice behaviour.

doi: 10.1038/nature23020

細胞生物学:in vivo FRET–FLIMが明らかにするシロイヌナズナの根における細胞型特異的なタンパク質間相互作用

In vivo FRET–FLIM reveals cell-type-specific protein interactions in Arabidopsis roots p.97

Imaging in living Arabidopsis roots reveals that protein complexes can change their conformation in a cell-type-dependent manner to regulate specific gene expression programs leading to precise specification and maintenance of particular cell fates within the root meristem.

doi: 10.1038/nature23317


Stimulation of functional neuronal regeneration from Müller glia in adult mice p.103

Inhibition of histone deacetylation allows the transcription factor Ascl1 to bind to key gene loci in Müller glia and drive the functional generation of retinal neurons in adult mice.

doi: 10.1038/nature23283


Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows p.108

Immunization of cows with a recombinant HIV envelope protein leads to the rapid development of potent, broadly neutralizing antibodies against HIV.

doi: 10.1038/nature23301

代謝:フルクトース 1,6-ビスリン酸とアルドラーゼはAMPKによるグルコース感知に関わっている

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK p.112

Glucose starvation activates AMPK via an AMP/ADP-independent mechanism that involves fructose-1,6-bisphosphate and aldolase.

doi: 10.1038/nature23275


Complex cellular logic computation using ribocomputing devices p.117

De-novo-designed RNA molecules are used to construct cellular computing devices that can implement complex logic functions.

doi: 10.1038/nature23271

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