Volume 508 Number 7496



Cancer crossroads p.287

Efforts to understand cancer genomes should take on a fresh focus.

doi: 10.1038/508287b


The democracy carousel p.287

Europe's re-examination of stem-cell rules is a waste of time and money.

doi: 10.1038/508287a


Practical nonsense p.288

Downgrading practical science will impede UK students in the global workplace

doi: 10.1038/508288a



Hepatitis C drugs not reaching poor p.295

Treatment guidelines for virus highlight challenge of paying for expensive drugs in low-income countries.

doi: 10.1038/508295a


Sperm RNA carries marks of trauma p.296

Stress alters the expression of small RNAs in male mice and leads to depressive behaviours in later generations.

doi: 10.1038/508296a


Panel homes in on sites for γ-ray detector p.297

Cherenkov Telescope Array will track high-energy photons to probe black holes, dark matter and relativity.

doi: 10.1038/508297a


IPCC report under fire p.298

Critics attack panel’s lack of specific guidance on how countries should lower emissions.

doi: 10.1038/508298a


Biologist defiant over stem-cell method p.299

Japanese author of controversial papers denies wrongdoing and stands by results as testing of her protocol begins.

doi: 10.1038/508299a


Mini satellites prove their scientific power p.300

Proliferation of ‘CubeSats’ offers fresh and fast way to gather space data.

doi: 10.1038/508300a

News Features


Power from the oceans: Blue energy p.302


doi: 10.1038/508302a


Toxicology: The plastics puzzle p.306


doi: 10.1038/508306a

News & Views


Evolutionary biology: Dating chimpanzees p.322


doi: 10.1038/508322a


Genetics: Up and down in Down's syndrome p.323


doi: 10.1038/508323a


Organic chemistry: Catalysis marches on p.324


doi: 10.1038/nature13225


Synthetic biology: Biocircuits in synchrony p.326


doi: 10.1038/nature13224


Thermoelectricity: The ugly duckling p.327


doi: 10.1038/508327a


Cell biology: The stressful influence of microbes p.328


doi: 10.1038/nature13220



The ensemble nature of allostery p.331

Allostery is the process by which biological macromolecules transmit the effect of binding at one site to another, often distal, functional site, allowing for the regulation of activity; here facilitation of allostery through dynamic and intrinsically disordered proteins is discussed, and a framework to unify the description of allosteric mechanisms for different systems is proposed.

doi: 10.1038/nature13001



Enantioselective construction of remote quaternary stereocentres p.340

A catalytic and enantioselective intermolecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids provides direct access to quaternary stereocentres remote from a carbonyl group.

doi: 10.1038/nature13231


Domains of genome-wide gene expression dysregulation in Down’s syndrome p.345

By studying the transcriptome of fetal cells of monozygotic twins discordant for trisomy 21, this paper finds that differential expression between the twins is organized in domains along all chromosomes; these gene expression dysregulation domains are conserved in the mouse model of Down’s syndrome and correlate with the lamina-associated domains and replication domains.

doi: 10.1038/nature13200


Brainstem nucleus MdV mediates skilled forelimb motor tasks p.351

The authors use a combination of viral tracing and genetics to characterize the diversity of neurons projecting from mouse brainstem to motor neurons that control limb movements; in particular they discover that the medullary reticular formation ventral part (MdV) is functionally specialized for skilled forelimb motor control.

doi: 10.1038/nature13023


Skilled reaching relies on a V2a propriospinal internal copy circuit p.357

Cervical propriospinal neurons (PNs) form a genetically accessible subclass of V2a interneurons that convey both premotor output and precerebellar copy signals; their ablation in mice impairs reaching movements selectively, and activation of their internal copy projection recruits a rapid cerebellar feedback loop that modulates forelimb movement.

doi: 10.1038/nature13021



Isotopic links between atmospheric chemistry and the deep sulphur cycle on Mars p.364

Isotopic analyses of 40 Martian meteorites indicate that assimilation of sulphur into Martian magmas was a common occurrence throughout much of the planet’s history and that the atmospheric imprint of photochemical processing preserved in Martian meteoritic sulphide and sulphate is distinct from that observed in terrestrial analogues.

doi: 10.1038/nature13175


Coherent suppression of electromagnetic dissipation due to superconducting quasiparticles p.369

The long-predicted suppression of quasiparticle dissipation in a Josephson junction when the phase difference across the junction is π is inferred from a sharp maximum in the energy relaxation time of a superconducting artificial atom.

doi: 10.1038/nature13017


Ultralow thermal conductivity and high thermoelectric figure of merit in SnSe crystals p.373

The main obstacle to improving the thermoelectric efficiency of a material arises from the common interdependence of electrical and thermal conductivity, whereas one ideally wants to raise the former while lowering the latter: a simple layered crystalline material — SnSe — is now reported that seems to have these qualities built in.

doi: 10.1038/nature13184


Mid-latitude interhemispheric hydrologic seesaw over the past 550,000 years p.378

Tropical and subtropical speleothems show that the latitudinal migration of the Intertropical Convergence Zone tends to produce increased precipitation in one hemisphere and drying in the other; now it is shown using speleothems from the Korean peninsula that this phenomenon extended to the mid-latitudes during the past 550,000 years.

doi: 10.1038/nature13076


A new fossil species supports an early origin for toothed whale echolocation p.383

Phylogenetic analysis of a new species of fossil toothed whale, Cotylocara mace, from the Oligocene epoch places it in a basal clade of odontocetes, and its features suggest that rudimentary echolocation evolved in the early Oligocene and was followed by convergent evolution in their skulls.

doi: 10.1038/nature13086


Rapid and tunable post-translational coupling of genetic circuits p.387

Protease competition is used to produce rapid and tunable coupling of genetic circuits, enabling a coupled clock network that can encode independent environmental cues into a single time series output, a form of frequency multiplexing in a genetic circuit context.

doi: 10.1038/nature13238


Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation p.392

The lengthening phase of ventral furrow formation in Drosophila gastrulation is driven by cytoplasmic flows triggered by apical constriction of mesoderm cells independent of the mechanical inputs from the basolateral membranes.

doi: 10.1038/nature13070


A committed precursor to innate lymphoid cells p.397

A committed precursor to innate lymphoid cell lineages, but not classical natural killer and lymphoid tissue inducer cells, is derived from common lymphoid precursors and distinguished by high levels of expression of the transcription factor PLZF.

doi: 10.1038/nature13047


Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 p.402

A broad-spectrum antiviral small molecule is reported to act as an inhibitor of viral polymerase activity and is shown to be effective in protecting non-human primates from lethal filovirus infection when administered after exposure.

doi: 10.1038/nature13027

細胞生物学:Caenorhabditis elegansでミトコンドリアを監視し守る経路

Caenorhabditis elegans pathways that surveil and defend mitochondria p.406

A genome-wide RNA interference screen in Caenorhabditis elegans identifies 45 genes with roles in protective pathways following drug- and genetic-disruption-induced mitochondrial inhibition.

doi: 10.1038/nature13204


miRNAs trigger widespread epigenetically activated siRNAs from transposons in Arabidopsis p.411

The generation of widespread epigenetically activated short interfering RNAs by the targeting of microRNAs to transposon transcripts in Arabidopsis thaliana is shown to be a latent mechanism that only becomes active when the transcripts are epigenetically reactivated, for example, during reprogramming of the germ line.

doi: 10.1038/nature13069


Structural basis for translocation by AddAB helicase–nuclease and its arrest at χ sites p.416

A dual-function helicase–nuclease, typified by RecBCD in Escherichia coli, acts on free DNA ends during bacterial double-stranded break repair until it reaches a χ sequence at which it pauses before continuing with modified enzymatic properties; here several crystal structures of the related AddAB enzyme from Bacillus subtilis bound to χ-containing DNA are presented, offering insight into χ recognition and its effect on DNA translocation.

doi: 10.1038/nature13037

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