As a commendable European law on personal data comes into force, the research community must not let excessive caution about data sharing, however understandable, become the default position.
doi: 10.1038/d41586-018-05220-y
An updated estimate of the economic damage of climate change makes a strong financial case for urgent action on greenhouse-gas emissions.
doi: 10.1038/d41586-018-05219-5
Electric cars are gaining ground fast but face fossil-fuel favouritism in the showroom.
doi: 10.1038/d41586-018-05218-6
International health organizations are in discussions with the Democratic Republic of Congo about how and whether to deploy treatments in addition to a vaccine.
doi: 10.1038/d41586-018-05205-x
The government’s proposals include stricter rules, and tougher penalties for researchers who break existing ones.
doi: 10.1038/d41586-018-05001-7
Scientists scramble to analyse data from Kilauea, which shot ash 9 kilometres into the atmosphere.
doi: 10.1038/d41586-018-05206-w
Queqiao probe will act as relay station for a future lunar lander, and carries two radio-astronomy experiments that will explore the early Universe.
doi: 10.1038/d41586-018-05231-9
Sweden is latest country to hold out on journal subscriptions, while negotiators share tactics to broker new deals with publishers.
doi: 10.1038/d41586-018-05191-0
腸内のマイクロバイオームは、一部の抗がん剤の効果に影響を及ぼしているらしいことが分かってきており、腸内細菌を利用した臨床試験計画も進んでいる。
doi: 10.1038/d41586-018-05208-8
パルサーと呼ばれる宇宙の灯台が生み出す電波は、周囲の物質によってゆがむ。今回、観測によって、こうした物質がレンズの役割を果たして、電波を集束し、パルサーの光度を高めていることが示された。
doi: 10.1038/d41586-018-05185-y
今回、ヒトの四肢の発生を妨げ得る遺伝子変異が特定され、肢発生時のWNTシグナル伝達経路の予期せぬ調節モードが見つかった。
doi: 10.1038/d41586-018-04820-y
今回、ヒトの脳の進化に影響を及ぼした可能性のある要因の革新的なコンピューター分析によって、大きくて急速に成長する脳の進化に重要な役割を担っていたのは、社会的要因ではなく生態学的要因であることが示唆された。
doi: 10.1038/d41586-018-05197-8
気候変動の緩和目標を達成すれば、経済的損害をかなり削減できることが、今回見いだされた。2人の経済学者が、こうした研究に用いられる方法について対立する見解を示している。
doi: 10.1038/d41586-018-05198-7
いくつかの神経変性疾患は、異なるタイプの細胞での異常なαシヌクレインタンパク質の蓄積と関連している。今回、細胞内因子の違いが、それぞれの細胞タイプにおけるこのタンパク質の特性を決めていることが分かった。
doi: 10.1038/d41586-018-04988-3
遺伝子KDM6Aの変異は、DNAと結合したヒストンタンパク質を修飾する酵素複合体を再配置させて、遺伝子発現を変化させることによって、膵臓がんのアグレッシブなサブタイプを駆動することが、今回分かった。
doi: 10.1038/d41586-018-05129-6
プラズモンと呼ばれる励起には、フォトニックデバイスを小型化できる可能性があるが、寿命が短いことが多い。今回、顕微鏡法によって、グラフェン材料のプラズモンがこの限界を低温で克服できることが明らかになった。
doi: 10.1038/d41586-018-05190-1
A large-scale mutagenesis screen identifies mutant phenotypes for over 11,000 protein-coding genes in bacteria that had previously not been assigned a specific function.
doi: 10.1038/s41586-018-0124-0
ANKRD16 attenuates neurodegeneration induced by a mutation in the editing domain of alanyl tRNA synthetase by directly accepting mis-activated serine from the synthetase before transfer to the tRNA, establishing a new mechanism by which editing defects are prevented.
doi: 10.1038/s41586-018-0137-8
The chromatin remodelling protein CHR2 interacts with Serrate in Arabidopsis to regulate microRNA biogenesis.
doi: 10.1038/s41586-018-0135-x
Radiation from the ‘black widow’ pulsar B1957+20 is amplified when a companion brown dwarf passes in front of the source, suggesting that plasma flowing from the companion acts as a lens.
doi: 10.1038/s41586-018-0133-z
The optical transmission spectrum for the ‘hot Saturn’ exoplanet WASP-96b reveals a clear atmosphere, an atmospheric sodium abundance and hence its metallicity, which is consistent with the metallicity trend observed in Solar System planets and exoplanets.
doi: 10.1038/s41586-018-0101-7
The fundamental limits to plasmon damping in graphene are determined using nanoscale infrared imaging at cryogenic temperatures, and plasmon polaritons are observed to propagate over 10 micrometres in high-mobility encapsulated graphene.
doi: 10.1038/s41586-018-0136-9
An optimal computationally efficient solution to the problem of finding the minimum taxi fleet size using a vehicle-sharing network is presented.
doi: 10.1038/s41586-018-0095-1
Liquid crystals are used to self-report and self-regulate either continuous or transient release of droplets or microparticles trapped within them in response to thermal, chemical, mechanical or biological stimuli.
doi: 10.1038/s41586-018-0098-y
The use of triple-oxygen-isotope data from continental shales spanning the past 3.7 billion years suggests that continental crust with near-modern average elevation and extent emerged about 2.5 billion years ago.
doi: 10.1038/s41586-018-0131-1
If the world can meet the target of limiting global warming to 1.5 °C, economic damage will probably be greatly reduced, especially in poorer countries.
doi: 10.1038/s41586-018-0071-9
Using estimates of metabolic costs of the brain and body, mathematical predictions suggest that the evolution of adult Homo sapiens-sized brains and bodies is driven by ecological rather than social challenges and is perhaps strongly promoted by culture.
doi: 10.1038/s41586-018-0127-x
Distinct strains of misfolded α-synuclein proteins, which aggregate in neurons in Lewy body diseases or in oligodendrocytes in multiple system atrophy, are formed as a consequence of differences between intracellular environments.
doi: 10.1038/s41586-018-0104-4
Independently of the LGR4/5/6 receptors, RSPO2 acts as a direct antagonistic ligand to RNF43 and ZNRF3 during embryogenesis, and specifies the position and number of limbs that an embryo should form.
doi: 10.1038/s41586-018-0118-y
The cell adhesion molecule Mxra8 is identified as a receptor for multiple arthritogenic alphaviruses such as chikungunya virus, and anti-Mxra8 monoclonal antibodies are shown to reduce rates of chikungunya virus infection in mice and a range of human cells.
doi: 10.1038/s41586-018-0121-3
Human lung and colorectal tumours contain a population of tumour-infiltrating lymphocytes that are specific for tumour-unrelated antigens and, unlike tumour-antigen-specific tumour-infiltrating lymphocytes, do not express CD39.
doi: 10.1038/s41586-018-0130-2
Microbial signals are crucial to the development of pre-leukaemic myeloproliferation, which can be induced by disrupting the intestinal barrier or by introducing systemic bacterial stimuli in Tet2-deficient mice.
doi: 10.1038/s41586-018-0125-z
In response to amino acid stimulation, the ubiquitin E3 ligase CUL3–KLHL22 promotes the activation of mTORC1, which may drive tumour growth in breast cancer.
doi: 10.1038/s41586-018-0128-9
Crystal structures and molecular dynamics simulations of voltage-gated sodium channels containing mutations that cause hypokalaemic and normokalaemic periodic paralysis indicate the pathogenic mechanisms of these conditions and suggest a target for the design of potential therapeutic and symptomatic drugs.
doi: 10.1038/s41586-018-0120-4
