Volume 557 Number 7706



Science needs clarity on Europe’s data-protection law p.467

As a commendable European law on personal data comes into force, the research community must not let excessive caution about data sharing, however understandable, become the default position.

doi: 10.1038/d41586-018-05220-y


Curbing global warming could save US$20 trillion p.467

An updated estimate of the economic damage of climate change makes a strong financial case for urgent action on greenhouse-gas emissions.

doi: 10.1038/d41586-018-05219-5


Customers put off electric cars … by electric-car sales staff p.468

Electric cars are gaining ground fast but face fossil-fuel favouritism in the showroom.

doi: 10.1038/d41586-018-05218-6



Experimental drugs poised for use in Ebola outbreak p.475

International health organizations are in discussions with the Democratic Republic of Congo about how and whether to deploy treatments in addition to a vaccine.

doi: 10.1038/d41586-018-05205-x


Indonesian plan to clamp down on foreign scientists draws protest p.476

The government’s proposals include stricter rules, and tougher penalties for researchers who break existing ones.

doi: 10.1038/d41586-018-05001-7


Hawaii volcano eruption holds clues to predicting similar events elsewhere p.477

Scientists scramble to analyse data from Kilauea, which shot ash 9 kilometres into the atmosphere.

doi: 10.1038/d41586-018-05206-w


Chinese satellite launch kicks off ambitious mission to Moon’s far side p.478

Queqiao probe will act as relay station for a future lunar lander, and carries two radio-astronomy experiments that will explore the early Universe.

doi: 10.1038/d41586-018-05231-9


Europe’s open-access drive escalates as university stand-offs spread p.479

Sweden is latest country to hold out on journal subscriptions, while negotiators share tactics to broker new deals with publishers.

doi: 10.1038/d41586-018-05191-0

News Features


How gut microbes are joining the fight against cancer p.482


doi: 10.1038/d41586-018-05208-8

News & Views


Astrophysics: Pulsars seen through a new lens p.494


doi: 10.1038/d41586-018-05185-y


Developmental biology: Rethinking WNT signalling p.495


doi: 10.1038/d41586-018-04820-y


Anthropology: Modelling provides clues to the evolution of human brain size p.496


doi: 10.1038/d41586-018-05197-8


Forum: Economics: The cost of a warming climate p.498


doi: 10.1038/d41586-018-05198-7


Neurodegeneration: Sabotage by the brain’s supporting cells helps fuel neurodegeneration p.499


doi: 10.1038/d41586-018-04988-3


Cancer: Pancreatic cancer foiled by a switch of tumour subtype p.500


doi: 10.1038/d41586-018-05129-6


Condensed-matter physics: Plasmon propagation pushed to the limit p.501


doi: 10.1038/d41586-018-05190-1



Mutant phenotypes for thousands of bacterial genes of unknown function p.503

A large-scale mutagenesis screen identifies mutant phenotypes for over 11,000 protein-coding genes in bacteria that had previously not been assigned a specific function.

doi: 10.1038/s41586-018-0124-0


ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase p.510

ANKRD16 attenuates neurodegeneration induced by a mutation in the editing domain of alanyl tRNA synthetase by directly accepting mis-activated serine from the synthetase before transfer to the tRNA, establishing a new mechanism by which editing defects are prevented.

doi: 10.1038/s41586-018-0137-8

RNA干渉:SWI2/SNF2 ATPアーゼCHR2はSerrateを介してpri-miRNAをリモデリングし、miRNA産生を妨げる

SWI2/SNF2 ATPase CHR2 remodels pri-miRNAs via Serrate to impede miRNA production p.516

The chromatin remodelling protein CHR2 interacts with Serrate in Arabidopsis to regulate microRNA biogenesis.

doi: 10.1038/s41586-018-0135-x



Pulsar emission amplified and resolved by plasma lensing in an eclipsing binary p.522

Radiation from the ‘black widow’ pulsar B1957+20 is amplified when a companion brown dwarf passes in front of the source, suggesting that plasma flowing from the companion acts as a lens.

doi: 10.1038/s41586-018-0133-z


An absolute sodium abundance for a cloud-free ‘hot Saturn’ exoplanet p.526

The optical transmission spectrum for the ‘hot Saturn’ exoplanet WASP-96b reveals a clear atmosphere, an atmospheric sodium abundance and hence its metallicity, which is consistent with the metallicity trend observed in Solar System planets and exoplanets.

doi: 10.1038/s41586-018-0101-7


Fundamental limits to graphene plasmonics p.530

The fundamental limits to plasmon damping in graphene are determined using nanoscale infrared imaging at cryogenic temperatures, and plasmon polaritons are observed to propagate over 10 micrometres in high-mobility encapsulated graphene.

doi: 10.1038/s41586-018-0136-9


Addressing the minimum fleet problem in on-demand urban mobility p.534

An optimal computationally efficient solution to the problem of finding the minimum taxi fleet size using a vehicle-sharing network is presented.

doi: 10.1038/s41586-018-0095-1


Self-reporting and self-regulating liquid crystals p.539

Liquid crystals are used to self-report and self-regulate either continuous or transient release of droplets or microparticles trapped within them in response to thermal, chemical, mechanical or biological stimuli.

doi: 10.1038/s41586-018-0098-y


Rapid emergence of subaerial landmasses and onset of a modern hydrologic cycle 2.5 billion years ago p.545

The use of triple-oxygen-isotope data from continental shales spanning the past 3.7 billion years suggests that continental crust with near-modern average elevation and extent emerged about 2.5 billion years ago.

doi: 10.1038/s41586-018-0131-1


Large potential reduction in economic damages under UN mitigation targets p.549

If the world can meet the target of limiting global warming to 1.5 °C, economic damage will probably be greatly reduced, especially in poorer countries.

doi: 10.1038/s41586-018-0071-9


Inference of ecological and social drivers of human brain-size evolution p.554

Using estimates of metabolic costs of the brain and body, mathematical predictions suggest that the evolution of adult Homo sapiens-sized brains and bodies is driven by ecological rather than social challenges and is perhaps strongly promoted by culture.

doi: 10.1038/s41586-018-0127-x


Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies p.558

Distinct strains of misfolded α-synuclein proteins, which aggregate in neurons in Lewy body diseases or in oligodendrocytes in multiple system atrophy, are formed as a consequence of differences between intracellular environments.

doi: 10.1038/s41586-018-0104-4


RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6 p.564

Independently of the LGR4/5/6 receptors, RSPO2 acts as a direct antagonistic ligand to RNF43 and ZNRF3 during embryogenesis, and specifies the position and number of limbs that an embryo should form.

doi: 10.1038/s41586-018-0118-y


Mxra8 is a receptor for multiple arthritogenic alphaviruses p.570

The cell adhesion molecule Mxra8 is identified as a receptor for multiple arthritogenic alphaviruses such as chikungunya virus, and anti-Mxra8 monoclonal antibodies are shown to reduce rates of chikungunya virus infection in mice and a range of human cells.

doi: 10.1038/s41586-018-0121-3

腫瘍免疫学:ヒト腫瘍浸潤細胞群中に多数存在し、独特の表現型を持つバイスタンダーCD8+ T細胞

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates p.575

Human lung and colorectal tumours contain a population of tumour-infiltrating lymphocytes that are specific for tumour-unrelated antigens and, unlike tumour-antigen-specific tumour-infiltrating lymphocytes, do not express CD39.

doi: 10.1038/s41586-018-0130-2


Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host p.580

Microbial signals are crucial to the development of pre-leukaemic myeloproliferation, which can be induced by disrupting the intestinal barrier or by introducing systemic bacterial stimuli in Tet2-deficient mice.

doi: 10.1038/s41586-018-0125-z


KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing p.585

In response to amino acid stimulation, the ubiquitin E3 ligase CUL3–KLHL22 promotes the activation of mTORC1, which may drive tumour growth in breast cancer.

doi: 10.1038/s41586-018-0128-9


Structural basis for gating pore current in periodic paralysis p.590

Crystal structures and molecular dynamics simulations of voltage-gated sodium channels containing mutations that cause hypokalaemic and normokalaemic periodic paralysis indicate the pathogenic mechanisms of these conditions and suggest a target for the design of potential therapeutic and symptomatic drugs.

doi: 10.1038/s41586-018-0120-4

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