Volume 523 Number 7560



Austerity bites p.255

If the UK government is serious about science, now is the time to prove it.

doi: 10.1038/523255b


Lessons must be learned after psychology torture inquiry p.255

An independent report on the American Psychological Association reveals the extent to which some psychologists colluded with US military and intelligence agencies to allow torture of prisoners.

doi: 10.1038/523255a


An education p.256

The world can no longer afford to support learning systems in which only the most capable students can thrive.

doi: 10.1038/523256a



Smart shots bring Nigeria to brink of polio eradication p.263

The nation has embraced the latest research and innovative approaches to vaccination.

doi: 10.1038/523263a


Alzheimer's data lawsuit is sign of growing tensions p.265

Battle between California universities raises questions about research ownership.

doi: 10.1038/nature.2015.17932


‘Organs-on-chips’ go mainstream p.266

Drug companies put in vitro systems through their paces.

doi: 10.1038/523266a


Forsaken pentaquark particle spotted at CERN p.267

Exotic subatomic particle confirmed at Large Hadron Collider after earlier false sightings.

doi: 10.1038/nature.2015.17968


California’s anti-vaping bill goes up in smoke p.267

Demise of legislation highlights rise of e-cigarette lobbying.

doi: 10.1038/523267a


First robust genetic links to depression emerge p.268

Discoveries energize hunt for genes connected to mental illness.

doi: 10.1038/523268a

News Features


The scientist of the future p.271


doi: 10.1038/523271a


Why we are teaching science wrong, and how to make it right p.272


doi: 10.1038/523272a


Reading, writing and high-energy physics p.276


doi: 10.1038/523276a

News & Views


Developmental biology: Nanotubes in the niche p.292


doi: 10.1038/nature14631


Earth science: Big geochemistry p.293


doi: 10.1038/523293a


Cancer: A dendritic-cell brake on antitumour immunity p.294


doi: 10.1038/523294a


Astrochemistry: Fullerene solves an interstellar puzzle p.296


doi: 10.1038/523296a


Systems biology: Network evolution hinges on history p.297


doi: 10.1038/nature14537


Symbiosis: Receptive to infection p.298


doi: 10.1038/nature14632



Volcanic–plutonic parity and the differentiation of the continental crust p.301

A global geochemical data set of volcanic and plutonic rocks indicates that differentiation trends from primitive basaltic to felsic compositions for volcanic versus plutonic samples are generally indistinguishable in subduction-zone settings, but are divergent in continental rifts.

doi: 10.1038/nature14584


Receptor-mediated exopolysaccharide perception controls bacterial infection p.308

This paper describes the discovery of the exopolysaccharide receptor (Epr3) in plants, and shows that its expression is induced upon perception of the bacterial Nod factors; the EPR3 receptor recognizes exopolysaccharides on the surface of rhizobia, thus controlling the symbiotic infection of the roots of legumes.

doi: 10.1038/nature14611


Progesterone receptor modulates ERα action in breast cancer p.313

Progesterones, oestrogens and their receptors (PR, ERα and ERβ) are essential in normal breast development and homeostasis, as well as in breast cancer; here it is shown that PR controls ERα function by redirecting where ERα binds to the chromatin, acting as a proliferative brake in ERα+ breast tumours.

doi: 10.1038/nature14583



Rapidly rotating second-generation progenitors for the ‘blue hook’ stars of ω Centauri p.318

The observed range of luminosities of the extremely hot ‘blue hook’ stars of the globular cluster ω Centauri is successfully explained by a model in which the progenitors of these stars are second-generation helium-rich stars characterized by a range of rotation rates arising during the cluster’s very early evolution.

doi: 10.1038/nature14516


Laboratory confirmation of C60+ as the carrier of two diffuse interstellar bands p.322

Laboratory measurements of the gas-phase spectrum of C60+ confirm that the diffuse interstellar bands observed at 9,632 ångströms and 9,577 ångströms arise as a result of C60+ in the interstellar medium.

doi: 10.1038/nature14566


Quantum-dot-in-perovskite solids p.324

Organohalide perovskites and preformed colloidal quantum dots are combined in the solution phase to produce epitaxially aligned ‘dots-in-a-matrix’ crystals that have both the excellent electrical transport properties of the perovskite matrix and the high radiative efficiency of the quantum dots.

doi: 10.1038/nature14563


Nanotubes mediate niche–stem-cell signalling in the Drosophila testis p.329

Drosophila male germline stem cells form previously unrecognized structures, microtubule-based nanotubes, which extend into the hub, a major niche component, to mediate the niche–stem-cell signalling.

doi: 10.1038/nature14602


Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria p.333

Fluorescent labelling is used to show that in E. coli, outer membrane protein (OMP) turnover is passive and binary in nature, and OMPs cluster to form islands in which diffusion of individual proteins is restricted owing to lateral interactions with other OMPs; new OMPs are inserted mostly at mid-cell, meaning that old OMP islands are displaced to the poles of growing cells.

doi: 10.1038/nature14461


Structural and functional features of central nervous system lymphatic vessels p.337

The central nervous system undergoes constant immune surveillance, but the route that immune cells take to exit the brain has been unclear as it had been thought to lack a classical lymphatic drainage system; here functional lymphatic vessels able to carry both fluid and immune cells from the cerebrospinal fluid are shown to be located in the brain meninges.

doi: 10.1038/nature14432

免疫学:HDLに結合したスフィンゴシン 1-リン酸はリンパ球形成と神経炎症を抑制する

HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation p.342

Apolipoprotein-M-bound sphingosine-1-phosphate (S1P) is found to restrain the generation of new lymphocytes—and, consequently, adaptive immune responses—by activating the S1P1 receptor on bone marrow lymphocyte progenitors in mice.

doi: 10.1038/nature14462


Conversion of abiraterone to D4A drives anti-tumour activity in prostate cancer p.347

The drug abiraterone is converted to Δ4-abiraterone (D4A) in mice and patients with prostate cancer, which has more potent anti-tumour activity and may lead to more effective therapies.

doi: 10.1038/nature14406


Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment p.352

Novel hotspot mutant p53 gain-of-function mouse model shows that tumours depend on its sustained expression, and genetic and pharmacological approaches reveal mutant p53 as an actionable cancer drug target.

doi: 10.1038/nature14430


A noisy linear map underlies oscillations in cell size and gene expression in bacteria p.357

Quantification of single-cell growth over long periods of time in E. coli shows transient oscillations in cell size, with periods stretching across more than ten generations; a noisy negative feedback on cell-size control is proposed in which cells with a small initial size tend to divide later than cells with a large initial size with implications for the genetic and physiological processes required.

doi: 10.1038/nature14562


Intersecting transcription networks constrain gene regulatory evolution p.361

Epistatic interactions, whereby a mutation's effect is contingent on another mutation, have been shown to constrain evolution within single proteins, and how such interactions arise in gene regulatory networks has remained unclear; here the appearance of pheromone-response regulator binding sites in the regulatory DNA of the a-specific genes of Saccharomyces cerevisiae are shown to have required specific changes in a second pathway during the evolution from its common ancestor with Candida albicans.

doi: 10.1038/nature14613


Structural basis for retroviral integration into nucleosomes p.366

Retroviruses such as HIV rely on the intasome, a tetramer of integrase protein bound to the viral DNA ends interacting with host chromatin, for integration into the host genome; the structure of the intasome as it interacts with a nucleosome is now solved, giving insight into the integration process.

doi: 10.1038/nature14495

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