Volume 550 Number 7677



Reclassify waste to shift the nuclear landscape p.429

The US Department of Energy should classify and dispose of nuclear rubbish according to risk.

doi: 10.1038/550429b


Many junior scientists need to take a hard look at their job prospects p.429

Permanent jobs in academia are scarce, and someone needs to let PhD students know.

doi: 10.1038/550429a


Data science can improve aid distribution p.430

Online platforms can help to steer emergency response and ensure money is well spent.

doi: 10.1038/550430a



Jupiter's stormy winds churn deep into the planet p.437

Juno probe discovers surprising activity in the giant planet’s interior.

doi: 10.1038/nature.2017.22866


Photons pair up like superconducting electrons p.438

Discovery raises questions about how a light 'supercurrent' might behave.

doi: 10.1038/nature.2017.22868


CRISPR hacks enable pinpoint repairs to genome p.439

Precision tools expand the number of ‘base editors’ available for manipulating DNA and RNA.

doi: 10.1038/550439a


India gears up for second Moon mission p.440

The Chandrayaan-2 orbiter, lander and rover will track how lunar dust might scupper settlement.

doi: 10.1038/nature.2017.22870


Sleeping sickness can now be cured with pills p.441

Researchers seek approval from regulators for this quicker, easier treatment.

doi: 10.1038/nature.2017.22856


Efforts to save leading Hungarian university hit hurdle p.442

US-registered Central European University faces another year of uncertainty over whether it can continue to operate in Hungary.

doi: 10.1038/nature.2017.22855

News Features


Out of the Syrian crisis, a data revolution takes shape p.444


doi: 10.1038/550444a


To stay young, kill zombie cells p.448


doi: 10.1038/550448a

News & Views


Inflammation: Memory beyond immunity p.460


doi: 10.1038/nature24154


Materials science: Atomistic views of deformation p.461


doi: 10.1038/550461a


Cancer development: Origins in the oesophagus p.463


doi: 10.1038/nature24150


Evolution: Fan-assisted insects p.464


doi: 10.1038/550464a


Biophysics: Rapid mass changes measured in cells p.465


doi: 10.1038/550465a


In Retrospect: Twenty years of drying droplets p.466


doi: 10.1038/550466a


Photobiology: How flowers get the blues to lure bees p.467


doi: 10.1038/nature24155



Disorder in convergent floral nanostructures enhances signalling to bees p.469

Disordered nanoscale striations on petals, tepals and bracts have evolved multiple times among flowering plants and provide a salient visual signal to foraging bumblebees (Bombus terrestris).

doi: 10.1038/nature24285


Inflammatory memory sensitizes skin epithelial stem cells to tissue damage p.475

After acute inflammation, epithelial stem cells retain a memory that accelerates restoration of the skin barrier during subsequent tissue damage, and this enhancement is dependent on the AIM2 inflammasome and its downstream effectors.

doi: 10.1038/nature24271


Molecular basis of USP7 inhibition by selective small-molecule inhibitors p.481

Small molecules are identified that inhibit the ubiquitin-specific protease USP7 with high affinity and specificity as explained by co-crystal structures, and are shown to reduce tumour growth in mice.

doi: 10.1038/nature24451



Structural phase transition in monolayer MoTe2 driven by electrostatic doping p.487

A structural phase transition in a monolayer of molybdenum ditelluride has been shown experimentally to be driven forwards and backwards by electrostatic doping.

doi: 10.1038/nature24043


Probing the limits of metal plasticity with molecular dynamics simulations p.492

The limits of dislocation-mediated metal plasticity are studied by using in situ computational microscopy to reduce the enormous amount of data from fully dynamic atomistic simulations into a manageable form.

doi: 10.1038/nature23472

材料科学:衝撃波によって駆動される双晶形成と格子ダイナミクスのin situ X線回折測定

In situ X-ray diffraction measurement of shock-wave-driven twinning and lattice dynamics p.496

In situ femtosecond X-ray diffraction measurements reveal that the dominant mechanism of shock-wave-driven deformation in tantalum changes from twinning to dislocation slip as pressure increases.

doi: 10.1038/nature24061


Inertial picobalance reveals fast mass fluctuations in mammalian cells p.500

A picobalance consisting of an optically excited microcantilever has been developed and used to measure the masses of individual healthy and virus-infected cells at high temporal and mass resolutions in culture conditions.

doi: 10.1038/nature24288


Evidence of marine ice-cliff instability in Pine Island Bay from iceberg-keel plough marks p.506

Plough marks in Pine Island Bay, West Antarctica, left by the keels of drifting icebergs 12,000 years ago provide evidence that marine ice-cliff instability can drive rapid ice-sheet retreat.

doi: 10.1038/nature24458


Indirect effects drive coevolution in mutualistic networks p.511

An approach to ecological interactions that integrates coevolutionary dynamics and network structure, showing that selection in mutualisms is shaped not only by the mutualistic partners but also by all sorts of indirect effects from other species in the network.

doi: 10.1038/nature24273


The prevalence of Plasmodium falciparum in sub-Saharan Africa since 1900 p.515

Spatial and temporal modelling of a large dataset of Plasmodium falciparum prevalence rates reveals cycles and trends of malaria transmission in sub-Saharan Africa over a 115 year period.

doi: 10.1038/nature24059


Network control principles predict neuron function in the Caenorhabditis elegans connectome p.519

Application of network control theory to the neuronal connectome of Caenorhabditis elegans, allowing prediction of the involvement of individual neurons in locomotion.

doi: 10.1038/nature24056


Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets p.524

Identification of a transmembrane protein, Mfsd2b, that is essential for the export of the signalling molecule sphingosine-1-phosphate (S1P) from red blood cells and platelets.

doi: 10.1038/nature24053


Transitional basal cells at the squamous–columnar junction generate Barrett’s oesophagus p.529

Barrett’s oesophagus—a metaplasia that can be induced by persistent acid reflux, and predisposes patients to oesophageal cancer—arises from a population of basal cells at the gastro-oesophageal junction.

doi: 10.1038/nature24269


USP7 small-molecule inhibitors interfere with ubiquitin binding p.534

The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7.

doi: 10.1038/nature24006


Nucleosome–Chd1 structure and implications for chromatin remodelling p.539

A cryo-electron microscopy structure of the chromatin remodelling factor Chd1 bound to a nucleosome leads to a model for DNA translocation by its ATPase motor.

doi: 10.1038/nature24046


Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots p.543

G-protein-coupled receptors and their G protein partners are studied by single-molecule imaging in living cells, which reveals hot spots on the cell membrane where receptors and G proteins interact and signal.

doi: 10.1038/nature24264

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