Confusion over UK funding from Europe’s nuclear agency is adding to the anxiety of staff at the Joint European Torus.
doi: 10.1038/d41586-018-05283-x
Japan needs to demonstrate that a promising therapy for damaged hearts works as claimed.
doi: 10.1038/d41586-018-05284-w
A lie-detection system being used by Spanish police highlights concerns about algorithms.
doi: 10.1038/d41586-018-05285-9
The latest clinical use of induced pluripotent stem cells excites researchers, but some fear the therapy will be rushed to market.
doi: 10.1038/d41586-018-05278-8
The ubiquitous particles are helping to map the innards of pyramids and volcanoes, and spot missing nuclear waste.
doi: 10.1038/d41586-018-05254-2
Diversity advocates seek strategies to correct alarming decrease.
doi: 10.1038/d41586-018-05203-z
Start-up firm NET Power is developing a new approach to capturing and storing carbon.
doi: 10.1038/d41586-018-05247-1
A federal court decision has left universities and companies working to preserve intellectual property rights worth billions.
doi: 10.1038/d41586-018-05273-z
自由に使える一定額の現金を定期的に給付する「最低所得保障」制度の検証実験が、貧困国を含めた複数の国で行われている。
doi: 10.1038/d41586-018-05259-x
HP1タンパク質を含む複合体が、特定の調節性DNA配列と結合して、ゲノム領域の局所的な凝集を促進するとともに、特定の細胞系譜への分化を駆動する関連遺伝子を抑制することが、今回分かった。
doi: 10.1038/d41586-018-05188-9
分子の微視的挙動は、量子物理によって支配されているため、通常のコンピューターを用いたモデル化が難しいことがある。今回、フォトニックチップによって、そうした挙動をシミュレートする汎用プラットフォームが得られた。
doi: 10.1038/d41586-018-05245-3
腸の微生物が産生する代謝分子が、ミクログリアと呼ばれる脳の免疫細胞を活性化し、中枢神経系の炎症応答を仲介する信号をアストロサイトに出すことが明らかになった。
doi: 10.1038/d41586-018-05113-0
今回、構造解析によって、細菌の酵素が宿主タンパク質へのタンパク質標識ユビキチンの付着を触媒する仕組みが明らかになり、病原性細菌が宿主細胞の機能を妨害する仕組みに光が当てられた。
doi: 10.1038/d41586-018-05250-6
今回、炭素の二次元形態であるグラフェンのエッジに、長い間探し求められていた磁性の証拠が見つかった。この知見によって、量子コンピューターに必要な論理ゲートの開発が可能になるかもしれない。
doi: 10.1038/d41586-018-05240-8
再設計された酵母ゲノムは、オンデマンドで大幅に再配列できるよう構築されている。今回、一連の研究によって、このゲノムシャッフリングシステムの汎用性が明らかになり、生物工学の応用に利用する方法が示された。
doi: 10.1038/d41586-018-05164-3
1968年に、DNA修復のある異常が、人々を太陽光に対して極端に敏感にする疾患の根底にあることが見いだされた。この知見は、がんの原因、診断、治療の研究に影響を及ぼし続けている。
doi: 10.1038/d41586-018-05255-1
Analysis of 2002–2016 GRACE satellite observations of terrestrial water storage reveals substantial changes in freshwater resources globally, which are driven by natural and anthropogenic climate variability and human activities.
doi: 10.1038/s41586-018-0123-1
By mapping vibrations in molecules to photons in waveguides, the vibrational quantum dynamics of various molecules are simulated using a photonic chip.
doi: 10.1038/s41586-018-0152-9
Excitatory input onto inhibitory interneurons in the developing mouse cortex acts through PTEN to protect interneurons from cell death and thus regulate the balance between excitation and inhibition.
doi: 10.1038/s41586-018-0139-6
Crystal structures of the Legionella effector SdeA in a ligand-free state and in complex with ubiquitin and NADH provide insight into SdeA-mediated phosphoribosyl-linked ubiquitination.
doi: 10.1038/s41586-018-0146-7
ZNFX-1 and WAGO-4 localize to germ granules in early C. elegans embryogenesis and later separate to form independent liquid-like droplets, and the temporal and spatial ordering of these droplets may help cells to organize complex RNA processing pathways.
doi: 10.1038/s41586-018-0132-0
Calculations show that if some dark-matter particles—less than one per cent—have a tiny charge, their coupling to baryons could cool the baryons enough to explain puzzling astrophysical observations.
doi: 10.1038/s41586-018-0151-x
The rate of carbon burning—12C + 12C fusion—in stars is boosted by resonant behaviour at astrophysical energies.
doi: 10.1038/s41586-018-0149-4
By functionalizing molecular graphene nanoribbons with stable spin-bearing nitronyl nitroxide radical groups, delocalized magnetic edge states are observed, with microsecond-scale spin coherence times.
doi: 10.1038/s41586-018-0154-7
In metal–semiconductor junctions, interfacial bonding and disorder cause deviations from theoretical predictions for the energy barrier, but delicately transferring pre-fabricated metal films onto two-dimensional semiconductors can overcome this challenge.
doi: 10.1038/s41586-018-0129-8
A sodium ion hydrated with three (rather than one, two, four or five) water molecules diffuses orders of magnitude more quickly than the other ion hydrates owing to the interfacial symmetry mismatch.
doi: 10.1038/s41586-018-0122-2
Computed tomography scanning of the Triassic fossil Megachirella wachtleri combined with a broad morphological and molecular phylogenetic analysis of reptile relationships confirm it as the most primitive stem squamate.
doi: 10.1038/s41586-018-0093-3
A long-term biodiversity manipulation experiment using plant communities on thirty Swedish lake islands reveals the importance of environmental context for determining the consequences of species loss at the ecosystem level.
doi: 10.1038/s41586-018-0138-7
Muscle stem cell quiescence in mice is maintained by a Notch–Collagen V–CALCR signalling pathway that is activated and sustained in a cell-autonomous fashion.
doi: 10.1038/s41586-018-0144-9
Analyses of antibody dynamics and subclinical infections show that across the population, variability in the infection strength of dengue viruses results in large-scale temporal changes in infection and disease risk that correlate poorly with age.
doi: 10.1038/s41586-018-0157-4
TGFα and VEGF-B produced by microglia regulate astrocyte function in the experimental autoimmune encephalomyelitis model of multiple sclerosis.
doi: 10.1038/s41586-018-0119-x
Crystal structures of the Legionella effectors SdeA and SdeD uncover the mechanism of a unique phosphoribosyl-ubiquitination reaction.
doi: 10.1038/s41586-018-0147-6
Structural and functional investigations demonstrate how bacterial enzymes ubiquitinate host proteins.
doi: 10.1038/s41586-018-0145-8
ADNP interacts with the chromatin remodeller CHD4 and the heterochromatin protein HP1 to form a complex termed ChAHP that represses gene expression independently of the histone H3K9me3 modification.
doi: 10.1038/s41586-018-0153-8
