Volume 557 Number 7707



Brexit uncertainty threatens fusion-energy research p.611

Confusion over UK funding from Europe’s nuclear agency is adding to the anxiety of staff at the Joint European Torus.

doi: 10.1038/d41586-018-05283-x


Stem-cell tests must show success p.611

Japan needs to demonstrate that a promising therapy for damaged hearts works as claimed.

doi: 10.1038/d41586-018-05284-w


Police use a computer to expose false testimony p.612

A lie-detection system being used by Spanish police highlights concerns about algorithms.

doi: 10.1038/d41586-018-05285-9



‘Reprogrammed’ stem cells approved to mend human hearts for the first time p.619

The latest clinical use of induced pluripotent stem cells excites researchers, but some fear the therapy will be rushed to market.

doi: 10.1038/d41586-018-05278-8


Muons: the little-known particles helping to probe the impenetrable p.620

The ubiquitous particles are helping to map the innards of pyramids and volcanoes, and spot missing nuclear waste.

doi: 10.1038/d41586-018-05254-2


Share of African American men going into medicine hits historic low p.621

Diversity advocates seek strategies to correct alarming decrease.

doi: 10.1038/d41586-018-05203-z

「二酸化炭素排出ゼロ」発電を目指す米国NET Power社の発電所のプロトタイプが完成し、燃焼器の性能テストへ。

Innovative zero-emissions power plant begins battery of tests p.622

Start-up firm NET Power is developing a new approach to capturing and storing carbon.

doi: 10.1038/d41586-018-05247-1


Rush to protect lucrative antibody patents kicks into gear p.623

A federal court decision has left universities and companies working to preserve intellectual property rights worth billions.

doi: 10.1038/d41586-018-05273-z

News Features


Money for nothing: the truth about universal basic income p.626


doi: 10.1038/d41586-018-05259-x

News & Views


Molecular biology: HP1 proteins safeguard embryonic stem cells p.640


doi: 10.1038/d41586-018-05188-9


Quantum physics: Molecular dynamics simulated by photons p.641


doi: 10.1038/d41586-018-05245-3


Immunology: Brain inflammatory cascade controlled by gut-derived molecules p.642


doi: 10.1038/d41586-018-05113-0


Structural biology: Deciphering the catalytic mechanism of bacterial ubiquitination p.644


doi: 10.1038/d41586-018-05250-6


Quantum materials: Spinning on the edge of graphene p.645


doi: 10.1038/d41586-018-05240-8


Synthetic biology: Synthetic yeast genome reveals its versatility p.647


doi: 10.1038/d41586-018-05164-3


In retrospect: Fifty years since DNA repair was linked to cancer p.648


doi: 10.1038/d41586-018-05255-1



Emerging trends in global freshwater availability p.651

Analysis of 2002–2016 GRACE satellite observations of terrestrial water storage reveals substantial changes in freshwater resources globally, which are driven by natural and anthropogenic climate variability and human activities.

doi: 10.1038/s41586-018-0123-1



Simulating the vibrational quantum dynamics of molecules using photonics p.660

By mapping vibrations in molecules to photons in waveguides, the vibrational quantum dynamics of various molecules are simulated using a photonic chip.

doi: 10.1038/s41586-018-0152-9


Pyramidal cell regulation of interneuron survival sculpts cortical networks p.668

Excitatory input onto inhibitory interneurons in the developing mouse cortex acts through PTEN to protect interneurons from cell death and thus regulate the balance between excitation and inhibition.

doi: 10.1038/s41586-018-0139-6


Structural basis of ubiquitin modification by the Legionella effector SdeA p.674

Crystal structures of the Legionella effector SdeA in a ligand-free state and in complex with ubiquitin and NADH provide insight into SdeA-mediated phosphoribosyl-linked ubiquitination.

doi: 10.1038/s41586-018-0146-7


Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance p.679

ZNFX-1 and WAGO-4 localize to germ granules in early C. elegans embryogenesis and later separate to form independent liquid-like droplets, and the temporal and spatial ordering of these droplets may help cells to organize complex RNA processing pathways.

doi: 10.1038/s41586-018-0132-0



A small amount of mini-charged dark matter could cool the baryons in the early Universe p.684

Calculations show that if some dark-matter particles—less than one per cent—have a tiny charge, their coupling to baryons could cool the baryons enough to explain puzzling astrophysical observations.

doi: 10.1038/s41586-018-0151-x

核物理学:天体物理学的エネルギーでの共鳴による12C + 12C核融合反応率の増大

An increase in the 12C + 12C fusion rate from resonances at astrophysical energies p.687

The rate of carbon burning—12C + 12C fusion—in stars is boosted by resonant behaviour at astrophysical energies.

doi: 10.1038/s41586-018-0149-4


Magnetic edge states and coherent manipulation of graphene nanoribbons p.691

By functionalizing molecular graphene nanoribbons with stable spin-bearing nitronyl nitroxide radical groups, delocalized magnetic edge states are observed, with microsecond-scale spin coherence times.

doi: 10.1038/s41586-018-0154-7


Approaching the Schottky–Mott limit in van der Waals metal–semiconductor junctions p.696

In metal–semiconductor junctions, interfacial bonding and disorder cause deviations from theoretical predictions for the energy barrier, but delicately transferring pre-fabricated metal films onto two-dimensional semiconductors can overcome this challenge.

doi: 10.1038/s41586-018-0129-8


The effect of hydration number on the interfacial transport of sodium ions p.701

A sodium ion hydrated with three (rather than one, two, four or five) water molecules diffuses orders of magnitude more quickly than the other ion hydrates owing to the interfacial symmetry mismatch.

doi: 10.1038/s41586-018-0122-2


The origin of squamates revealed by a Middle Triassic lizard from the Italian Alps p.706

Computed tomography scanning of the Triassic fossil Megachirella wachtleri combined with a broad morphological and molecular phylogenetic analysis of reptile relationships confirm it as the most primitive stem squamate.

doi: 10.1038/s41586-018-0093-3


Long-term effects of species loss on community properties across contrasting ecosystems p.710

A long-term biodiversity manipulation experiment using plant communities on thirty Swedish lake islands reveals the importance of environmental context for determining the consequences of species loss at the ecosystem level.

doi: 10.1038/s41586-018-0138-7


Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche p.714

Muscle stem cell quiescence in mice is maintained by a Notch–Collagen V–CALCR signalling pathway that is activated and sustained in a cell-autonomous fashion.

doi: 10.1038/s41586-018-0144-9


Reconstruction of antibody dynamics and infection histories to evaluate dengue risk p.719

Analyses of antibody dynamics and subclinical infections show that across the population, variability in the infection strength of dengue viruses results in large-scale temporal changes in infection and disease risk that correlate poorly with age.

doi: 10.1038/s41586-018-0157-4


Microglial control of astrocytes in response to microbial metabolites p.724

TGFα and VEGF-B produced by microglia regulate astrocyte function in the experimental autoimmune encephalomyelitis model of multiple sclerosis.

doi: 10.1038/s41586-018-0119-x


Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector p.729

Crystal structures of the Legionella effectors SdeA and SdeD uncover the mechanism of a unique phosphoribosyl-ubiquitination reaction.

doi: 10.1038/s41586-018-0147-6


Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination p.734

Structural and functional investigations demonstrate how bacterial enzymes ubiquitinate host proteins.

doi: 10.1038/s41586-018-0145-8


Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes p.739

ADNP interacts with the chromatin remodeller CHD4 and the heterochromatin protein HP1 to form a complex termed ChAHP that represses gene expression independently of the histone H3K9me3 modification.

doi: 10.1038/s41586-018-0153-8

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