Volume 500 Number 7460



Forensics fiasco p.5

Inconsistent standards and a lack of research investment have left UK legal science in chaos.

doi: 10.1038/500005b


The test for Abenomics p.5

Japanese Prime Minister Shinzo Abe has been buoyed by election success, but he must show that his science policies take the opinions of researchers into account.

doi: 10.1038/500005a



Labs vie for X-ray source p.13

California facilities respond to US panel’s call for a powerful free-electron laser.

doi: 10.1038/500013a


NIH mulls rules for validating key results p.14

US biomedical agency could enlist independent labs for verification.

doi: 10.1038/500014a


Microbiome research goes without a home p.16

Scientists say core tools and expertise remain necessary.

doi: 10.1038/500016a


Pilot projects bury carbon dioxide in basalt p.18

Two experiments test viability of sequestering emissions in porous layers of hard rock.

doi: 10.1038/500018a

News Features


Archaeology: The milk revolution p.20


doi: 10.1038/500020a

News & Views


Regenerative biology: On with their heads p.32


doi: 10.1038/nature12458


Climate science: Unequal equinoxes p.33


doi: 10.1038/nature12456


Alzheimer's disease: From big data to mechanism p.34


doi: 10.1038/nature12457


Psychology: Spot the gorilla p.36


doi: 10.1038/500036a


Nanotechnology: Tiny thermometers used in living cells p.36


doi: 10.1038/500036b


Cancer: Angiogenic awakening p.37


doi: 10.1038/nature12459



Myc-driven endogenous cell competition in the early mammalian embryo p.39

An in vivo genetic approach to generate mosaic expression of Myc in the mouse epiblast reveals evidence of cell competition, a tissue homeostasis mechanism first described in Drosophila by which viable but suboptimal cells are eliminated from metazoan tissues; during normal development Myc expression levels in the epiblast are heterogeneous, and endogenous cell competition refines the epiblast cell population through the apoptotic elimination of cells with low relative Myc levels.

doi: 10.1038/nature12389

医学:アルツハイマー病におけるAPOE ε4 エフェクターの統合ゲノミクスによる同定

Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease p.45

Whole transcriptome differential gene co-expression correlation analysis of cerebral cortex of APOE ε4 allele carriers and late-onset Alzheimer’s disease patients reveals an APOE ε4 carrier transcription network pattern that resembles that of late-onset Alzheimer’s disease and also identifies new genes of interest for further study.

doi: 10.1038/nature12415



An age difference of two billion years between a metal-rich and a metal-poor globular cluster p.51

An absolute age of about ten billion years is determined for the globular cluster 47 Tucanae, which is about two billion years younger than the cluster NGC 6397 is thought to be, suggesting that metal-rich clusters like 47 Tucanae formed later than metal-poor clusters like NGC 6397.

doi: 10.1038/nature12334


Nanometre-scale thermometry in a living cell p.54

A nanoscale thermometry technique that uses coherent manipulation of the electronic spin associated with nitrogen–vacancy colour centres in diamond makes it possible to detect temperature variations as small as 1.8 millikelvin in ultrapure samples and to control and map temperature gradients within living cells.

doi: 10.1038/nature12373


Stretchable nanoparticle conductors with self-organized conductive pathways p.59

Stretchable conductors have many applications, from flexible electronics to medical implants; here polyurethane is filled with gold nanoparticles to give a composite with tunable viscoelastic properties arising from the dynamic self-organization of the nanoparticles under stress.

doi: 10.1038/nature12401


Seasonal sea surface cooling in the equatorial Pacific cold tongue controlled by ocean mixing p.64

In the tropics, a strong seasonal cycle in sea surface temperature exists despite comparatively constant radiation inputs; turbulent mixing from below is now shown to control the cooling phase of the seasonal cycle in the equatorial Pacific ‘cold tongue’ at 140° W.

doi: 10.1038/nature12363


Feeding andesitic eruptions with a high-speed connection from the mantle p.68

Diffusion modelling of nickel in mantle melts beneath a volcano reveals the short timescales of magma movement from the base of the crust to the surface in the months to years before an eruption.

doi: 10.1038/nature12342


The molecular logic for planarian regeneration along the anterior–posterior axis p.73

More than a century ago, Thomas Hunt Morgan attempted to explain the extraordinary regenerative ability of planarians such as Dugesia japonica, which can regenerate a complete individual even from a tail fragment, by proposing that two opposing morphogenetic gradients along the anterior–posterior axis are required for regeneration; here ERK and β-catenin signalling are shown to form these gradients.

doi: 10.1038/nature12359


Restoration of anterior regeneration in a planarian with limited regenerative ability p.77

Although the capacity for tissue regeneration of planarians is exceptional, planarians with more limited regenerative capacities are known; this study of Procotyla fluviatilis, a planarian with restricted ability to replace missing tissues, shows that Wnt signalling is aberrantly regulated in regeneration-deficient tissues and that downregulation of Wnt signalling in these regions restores regenerative abilities, revealing that manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential.

doi: 10.1038/nature12403


Reactivating head regrowth in a regeneration-deficient planarian species p.81

Although the capacity for tissue regeneration of planarians is exceptional, planarians with more limited regenerative capacities are known; here knocking down components of the Wnt signalling pathway rescues head regeneration in the regeneration-impaired planarian Dendrocoelum lacteum, revealing that manipulating a single signalling pathway can reverse the evolutionary loss of regenerative potential.

doi: 10.1038/nature12414


Dual-mode operation of neuronal networks involved in left–right alternation p.85

A group of transcriptionally defined spinal neurons, V0 neurons, are identified as necessary for the control of normal alternation of left and right limbs in mice.

doi: 10.1038/nature12286


AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes p.89

Fibroblasts deficient in the activation-induced cytidine deaminase (AID) enzyme are shown to fail to stabilize in the pluripotent state, despite initiating the expression of pluripotency genes.

doi: 10.1038/nature12299


A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis p.93

A multiprotein complex containing AML1–ETO, the most common fusion protein found in acute myeloid leukaemia, is revealed and analysed in leukaemic cells, and a novel, functionally important protein-binding interface is identified.

doi: 10.1038/nature12287


Reshaping of the conformational search of a protein by the chaperone trigger factor p.98

The bacterial chaperone named trigger factor is found to stabilize protein folding intermediates that eventually convert to the native state, suggesting that chaperones play a direct role in instructing protein folding.

doi: 10.1038/nature12293


Structural basis for the inhibition of bacterial multidrug exporters p.102

The first inhibitor-bound X-ray crystal structures of the bacterial multidrug efflux transporter AcrB and its homologue MexB are presented, with the inhibitor shown to bind the transporter through a narrow hydrophobic pit, thereby preventing rotation of AcrB and MexB monomers.

doi: 10.1038/nature12300


Unusual base pairing during the decoding of a stop codon by the ribosome p.107

Here, the structure of the 30S ribosomal subunit and the 70S ribosome in complex with a messenger RNA with pseudouridine in the place of uridine reveals unexpected base pairing.

doi: 10.1038/nature12302

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