All shook up over topology p.257

Physicists and mathematicians have bonded over their shared explorations of bizarre states of matter.

doi: 10.1038/547257b

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New Antarctic iceberg echoes old problem p.257

The break in the Larsen C ice shelf highlights the vulnerable nature of other Antarctic environments and the impact people are having on the continent.

doi: 10.1038/547257a

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Ditching diesel won’t clear the air p.258

Arguments about the environmental benefits of petrol or diesel engines are outdated.

doi: 10.1038/547258a

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Satellite snafu masked true sea-level rise for decades p.265

Revised tallies confirm that the rate of sea-level rise is accelerating as the Earth warms and ice sheets thaw.

doi: 10.1038/nature.2017.22312

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Female astronomers of colour face daunting discrimination p.266

Two-fifths report feeling unsafe at work, and 18% have concerns about attending conferences.

doi: 10.1038/nature.2017.22291

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European Commission urges logging ban in ancient Białowieża Forest p.267

Europe’s highest court will rule on Poland's policy that encourages tree-felling in biodiversity hotspot.

doi: 10.1038/nature.2017.22309

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US lawmakers seek $1.1-billion boost for the NIH p.268

Legislation introduced in the House of Representatives also rejects a White House plan to cut 'indirect cost' payments to research institutions.

doi: 10.1038/nature.2017.22307

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Climate scientists flock to France’s call p.269

President said ‘Make Our Planet Great Again’ — and researchers signed up.

doi: 10.1038/nature.2017.22318

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Engineered cell therapy for cancer gets thumbs up from FDA advisers p.270

Treatment shows promise in young people with leukaemia, but safety risks abound.

doi: 10.1038/nature.2017.22304

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News Features


The strange topology that is reshaping physics p.272


doi: 10.1038/547272a

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News & Views


Gravitational waves: Stellar palaeontology p.284


doi: 10.1038/547284a

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Archaeology: Early signs of human presence in Australia p.285


doi: 10.1038/547285a

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Materials science: Chemistry and physics happily wed p.287


doi: 10.1038/547287a

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Immunology: Nervous crosstalk to make antibodies p.288


doi: 10.1038/nature23097

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Imaging techniques: X-rays used to watch spins in 3D p.290


doi: 10.1038/547290a

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Cancer: Keeping it real to kill glioblastoma p.291

ある種の脳腫瘍の生存に不可欠な遺伝子を、in vitroin vivoでスクリーニングして特定した結果は、ほとんど重複を示しておらず、in vitro研究を解釈する際に注意が必要であることを明確に示している。

doi: 10.1038/nature23095

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Ribosomes are optimized for autocatalytic production p.293

The large number of small, similarly sized proteins and the small number of heavy RNA molecules that make up a ribosome reduce the time required for reproduction.

doi: 10.1038/nature22998

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Topological quantum chemistry p.298

A complete electronic band theory is presented that describes the global properties of all possible band structures and materials, and can be used to predict new topological insulators and semimetals.

doi: 10.1038/nature23268

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Human occupation of northern Australia by 65,000 years ago p.306

Optical dating of sediments containing stone artefacts newly excavated at Madjedbebe, Australia, indicate that human occupation began around 65,000 years ago, thereby setting a new minimum age for the arrival of people in Australia.

doi: 10.1038/nature22968

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The whole-genome landscape of medulloblastoma subtypes OPEN p.311

Genomic analysis of 491 medulloblastoma samples, including methylation profiling of 1,256 cases, effectively assigns candidate drivers to most tumours across all molecular subgroups.

doi: 10.1038/nature22973

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TFH-derived dopamine accelerates productive synapses in germinal centres p.318

Human follicular helper T cells engaging in synaptic interactions with germinal centre B cells release dopamine stored in chromogranin B+ granules, causing rapid externalization of ICOS ligand, which in turn enhances CD40L delivery to the synaptic cleft and synaptic contact, and results in an accelerated response.

doi: 10.1038/nature23013

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Experimental signatures of the mixed axial–gravitational anomaly in the Weyl semimetal NbP p.324

A positive magneto-thermoelectric conductance is observed in the Weyl semimetal niobium phosphide, suggesting the presence of the elusive mixed axial–gravitational anomaly.

doi: 10.1038/nature23005

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Three-dimensional magnetization structures revealed with X-ray vector nanotomography p.328

Techniques exist for imaging the magnetization patterns of magnetic thin films and at the surfaces of magnets, but here hard-X-ray tomography is used to image the three-dimensional magnetic structure within a micrometre-sized magnet in the vicinity of Bloch points.

doi: 10.1038/nature23006

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Nitrogen reduction and functionalization by a multimetallic uranium nitride complex p.332

A complex containing two uranium ions and three potassium ions, held together by a nitride group and a flexible molecular framework, can reduce and functionalize N2 under mild conditions.

doi: 10.1038/nature23279

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Large-scale physical activity data reveal worldwide activity inequality p.336

A huge smartphone dataset of physical activity yields global insights, revealing that activity inequality predicts obesity better than does volume of activity and that much of the inequality is a result of reduced activity in females.

doi: 10.1038/nature23018

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Infant viewing of social scenes is under genetic control and is atypical in autism p.340

Monozygotic twins show high concordance in eye- and mouth-looking, and this behaviour is markedly reduced in toddlers with autism spectrum disorder.

doi: 10.1038/nature22999

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CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria p.345

The authors encode pixel values of a short motion picture into the DNA of a population of Escherichia coli.

doi: 10.1038/nature23017

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Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration p.350

Two independent systems impairing hepatocyte proliferation during liver injury cause physiologically significant levels of functional hepatocyte regeneration from biliary cells.

doi: 10.1038/nature23015

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がん:神経膠芽腫において転写伸長因子はin vivoでがん依存性を示す

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma p.355

An in vivo RNA interference screening strategy in glioblastoma enabled the identification of a host of epigenetic targets required for glioblastoma cell survival that were not identified by parallel standard screening in cell culture, including the transcription pause–release factor JMJD6, and could be a powerful tool to uncover new therapeutic targets in cancer.

doi: 10.1038/nature23000

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Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike p.360

New high-resolution cryo-electron microscopy structures of the HIV-1 envelope protein provide a detailed description and understanding of how the HIV-1 fusion machinery functions and how it changes its structure over time to convert from the pre-fusion to the fusion-intermediate conformation.

doi: 10.1038/nature23010

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K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site p.364

Polymodal thermo- and mechanosensitive two-pore domain potassium (K2P) channels of the TREK subfamily generate ‘leak’ currents that regulate neuronal excitability, respond to lipids, temperature and mechanical stretch, and influence pain, temperature perception and anaesthetic responses. These dimeric voltage-gated ion channel (VGIC) superfamily members have a unique topology comprising two pore-forming regions per subunit. In contrast to other potassium channels, K2P channels use a selectivity filter ‘C-type’ gate as the principal gating site. Despite recent advances, poor pharmacological profiles of K2P channels limit mechanistic and biological studies. Here we describe a class of small-molecule TREK activators that directly stimulate the C-type gate by acting as molecular wedges that restrict interdomain interface movement behind the selectivity filter. Structures of K2P2.1 (also known as TREK-1) alone and with two selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activators—an N-aryl-sulfonamide, ML335, and a thiophene-carboxamide, ML402—define a cryptic binding pocket unlike other ion channel small-molecule binding sites and, together with functional studies, identify a cation–π interaction that controls selectivity. Together, our data reveal a druggable K2P site that stabilizes the C-type gate ‘leak mode’ and provide direct evidence for K2P selectivity filter gating.

doi: 10.1038/nature22988

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