Review Abstract


Vascular cognitive impairment

2018年2月15日 Nature Reviews Disease Primers Article number: 18003 (2018) doi: 10.1038/nrdp.2018.3



このPrimeViewでは、van der FlierらによるPrimerの内容にそって、血管性認知障害(VCI)に関連する、人口統計学的要因、生活習慣、特定の慢性疾患などのリスク因子を中心に取りまとめる。

The term vascular cognitive impairment (VCI) was introduced around the start of the new millennium and refers to the contribution of vascular pathology to any severity of cognitive impairment, ranging from subjective cognitive decline and mild cognitive impairment to dementia. Although vascular pathology is common in elderly individuals with cognitive decline, pure vascular dementia (that is, dementia caused solely by vascular pathology) is uncommon. Indeed, most patients with vascular dementia also have other types of pathology, the most common of which is Alzheimer disease (specifically, the diffuse accumulation of amyloid-β plaques and neurofibrillary tangles composed of tau). At present, the main treatment for VCI is prevention by treating vascular diseases and other risk factors for VCI, such as hypertension and diabetes mellitus. Despite the current paucity of disease-modifying pharmacological treatments, we foresee that eventually, we might be able to target specific brain diseases to prevent cognitive decline and dementia.