Research Abstract


The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration

2014年8月13日 Scientific Reports 4 : 6043 doi: 10.1038/srep06043


Md. Rafiqul Islam1, 中村 研太2, Martin Miguel Casco-Robles1, Ailidana Kunahong1, 井波 航1, 外山 史3, 丸尾 文昭2 & 千葉 親文2

  1. 筑波大学大学院 生命環境科学研究科
  2. 筑波大学 生命環境系
  3. 宇都宮大学大学院 工学研究科
The reprogramming of retinal pigment epithelium (RPE) cells in the adult newt immediately after retinal injury is an area of active research for the study of retinal disorders and regeneration. We demonstrate here that unlike embryonic/larval retinal regeneration, adult newt RPE cells are not directly reprogrammed into retinal stem/progenitor cells; instead, they are programmed into a unique state of multipotency that is similar to the early optic vesicle (embryo) but preserves certain adult characteristics. These cells then differentiate into two populations from which the prospective-neural retina and -RPE layers are formed with the correct polarity. Furthermore, our findings provide insight into the similarity between these unique multipotent cells in newts and those implicated in retinal disorders, such as proliferative vitreoretinopathy, in humans. These findings provide a foundation for biomedical approaches that aim to induce retinal self-regeneration for the treatment of RPE-mediated retinal disorders.