Research Abstract


Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

2012年11月12日 Scientific Reports 2 : 799 doi: 10.1038/srep00799


川崎 範隆1, 浅田 梨絵1, 齋藤 敦1, 金本 聡自1 & 今泉 和則1

  1. 広島大学大学院 医歯薬保健学研究科 分子細胞情報学
Adipose tissue plays a central role in maintaining metabolic homeostasis under normal conditions. Metabolic diseases such as obesity and type 2 diabetes are often accompanied by chronic inflammation and adipose tissue dysfunction. In this study, we observed that endoplasmic reticulum (ER) stress and the inflammatory response occurred in adipose tissue of mice fed a high-fat diet for a period of 16 weeks. After 16 weeks of feeding, ER stress markers increased and chronic inflammation occurred in adipose tissue. We found that ER stress is induced by free fatty acid (FFA)-mediated reactive oxygen species (ROS) generation and up-regulated gene expression of inflammatory cytokines in 3T3-L1 adipocytes. Oral administration to obese mice of chemical chaperons, which alleviate ER stress, improved chronic inflammation in adipose tissue, followed by the suppression of increased body weight and improved insulin signaling. These results indicate that ER stress plays important pathophysiological roles in obesity-induced adipose tissue dysfunction.