Research press release


Nature Microbiology

Neutralizing gut bacterial fragments improves autoimmunity



今回Yue Wangたちは、ペプチドグリカンサブユニットと呼ばれる細胞壁断片が免疫系を活性化し、自己免疫性関節炎を悪化させることをマウスで明らかにした。次に、Wangたちはこの断片を特異的に中和する抗体を開発し、この抗体をマウスに投与するといくつかの自己免疫疾患の程度が軽減したり、発症が減ったりすることを示した。


An antibody that neutralizes a specific type of bacterial cell wall fragment, lessening the severity of several autoimmune diseases in mice, is reported in a paper published online in Nature Microbiology this week. Further research is needed to determine whether this neutralization approach is safe and effective in human patients with autoimmune disease.

Bacteria are powerful activators of the immune system. Previous work suggests a link between human microbiota - the bacteria that normally live on and inside us - and the development of autoimmune disease. It has also been shown that microbiota can release pieces of their cell walls into circulating blood, and that cell walls can aggravate autoimmune disease in animals.

Yue Wang and colleagues show that a type of cell wall fragment known as a peptidoglycan subunit turns on the immune system and worsens autoimmune arthritis in mice. They then developed an antibody that specifically neutralizes this fragment, and demonstrated that administering the antibody in mice lessens the severity and onset of several autoimmune disorders.

The study offers a potentially new treatment avenue for autoimmunity: administering an antibody to remove a bacterial immune signal rather than using immunosuppression drugs, which can have undesirable side effects.

doi: 10.1038/s41564-019-0381-1


メールマガジンリストの「Nature 関連誌今週のハイライト」にチェックをいれていただきますと、毎週各ジャーナルからの最新の「注目のハイライト」をまとめて皆様にお届けいたします。