Research press release


Nature Microbiology

Links between gut microbes and mental health identified



Jeroen Raesたちは今回、微生物相の特性が生活の質(QOL)やうつとどのように関連しているかの研究を行った。Flemish Gut Flora Project(FGFP)に参加した1054人について、微生物相データを、うつに関する自己申告データおよび一般開業医による診断データと組み合わせて解析したところ、メンタルヘルスに正の関連あるいは負の関連を持つ特異的な腸内細菌グループが見つかった。うつ病患者では、恒常的にCoprococcus属とDialister属の細菌群が乏しく、このことはFGFPとは別のコホート研究Dutch LifeLinesDEEPに参加した1063人でも確かめられた。


Specific gut bacteria were associated with depression across two different human sample groups, each consisting of more than 1,000 individuals, a paper published online this week in Nature Microbiology reports. These findings resulted from bioinformatics analyses and will need to be confirmed experimentally, however, they may help direct and streamline future microbiome-brain research.

The relationship between gut microbial metabolism and mental health is a complex topic in microbiome research. Gut microbiome-brain communication has mostly been explored in animal models, with human research lagging behind.

Jeroen Raes and colleagues studied how microbiome features correlate with quality of life and depression. The authors combined microbiome data together with self-reported and general practitioner-diagnosed depression data from 1,054 human individuals enrolled in the Flemish Gut Flora Project (FGFP). They identified specific groups of gut bacteria that positively or negatively correlated with mental health. The authors found that two groups of bacteria, Coprococcus and Dialister, were consistently depleted in individuals with depression. This was validated in an independent group of 1,063 individuals from the Dutch LifeLinesDEEP cohort.

The authors also created a catalogue of gut microbiome functions based on the ability to produce or degrade molecules that can potentially interact with the human nervous system. They applied this catalogue to faecal metagenome data from a subset of the sample group, including treatment-resistant major depression patients and healthy controls. The results revealed a positive association between the potential ability of the gut microbiome to synthesize a dopamine metabolite and mental quality of life.

doi: 10.1038/s41564-018-0337-x


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