Research Abstract


Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ

2013年10月1日 Nature Communications 4 : 2497 doi: 10.1038/ncomms3497


平山 雅敏1,2, 小川 美帆2,3, 大島 正充2, 関根 由里恵4, 石田 研太郎2, 山下 健太郎5, 池田 和貴6, 榛村 重人1, 川北 哲也1, 坪田 一男1 & 辻 孝2,3,4

  1. 慶應義塾大学 医学部 眼科学教室
  2. 東京理科大学 総合研究機構
  3. 株式会社 オーガンテクノロジーズ
  4. 東京理科大学院 基礎工学研究科 生物工学専攻
  5. 東京理科大学 基礎工学部 生物工学科
  6. 慶應義塾大学 先端生命科学研究所
The lacrimal gland has a multifaceted role in maintaining a homeostatic microenvironment for a healthy ocular surface via tear secretion. Dry-eye disease, which is caused by lacrimal gland dysfunction, is one of the most prevalent eye diseases that cause corneal epithelial damage and results in significant loss of vision and a reduction in the quality of life. Here we demonstrate orthotopic transplantation of bioengineered lacrimal gland germs into adult mice with an extra-orbital lacrimal gland defect, a mouse model that mimics the corneal epithelial damage caused by lacrimal gland dysfunction. The bioengineered lacrimal gland germs and harderian gland germs both develop in vivo and achieve sufficient physiological functionality, including tear production in response to nervous stimulation and ocular surface protection. This study demonstrates the potential for bioengineered organ replacement to functionally restore the lacrimal gland.