Research Abstract


Trunk exoskeleton in teleosts is mesodermal in origin

2013年3月27日 Nature Communications 4 : 1639 doi: 10.1038/ncomms2643


島田 敦子1, 河西 通1, 兼子 拓也1, 吉原 大樹2, 矢野 十織2, 猪早 敬二3, 木下 政人4, 亀井 保博5, 田村 宏治2 & 武田 洋幸1

  1. 東京大学大学院 理学系研究科 生物科学専攻
  2. 東北大学大学院 生命科学研究科 生命機能科学専攻
  3. 東京工業大学 高次生命情報講座
  4. 京都大学 農学研究科 応用生物科学専攻
  5. 自然科学研究機構 基礎生物学研究所 生物機能解析センター 光学解析室
The vertebrate mineralized skeleton is known to have first emerged as an exoskeleton that extensively covered the fossil jawless fish. The evolutionary origin of this exoskeleton has long been attributed to the emergence of the neural crest, but experimental evaluation for this is still poor. Here we determine the embryonic origin of scales and fin rays of medaka (teleost trunk exoskeletons) by applying long-term cell labelling methods, and demonstrate that both tissues are mesodermal in origin. Neural crest cells, however, fail to contribute to these tissues. This result suggests that the trunk neural crest has no skeletogenic capability in fish, instead highlighting the dominant role of the mesoderm in the evolution of the trunk skeleton. This further implies that the role of the neural crest in skeletogenesis has been predominant in the cephalic region from the early stage of vertebrate evolution.