Volume 502 Number 7473



All together now p.593

Online discussion is an essential aspect of the post-publication review of findings.

doi: 10.1038/502593a


Time to talk p.593

Proposals to bring hydrofluorocarbons under the auspices of the Montreal Protocol provide a simple test of the international community’s commitment to tackling climate change.

doi: 10.1038/502593b

英国の人気SFテレビ番組「Doctor Who」が50周年を迎え、科学の法則に反していても、ストーリーや工夫で科学がドラマになる可能性を示している。

Playful paradoxes p.594

A half-century of Doctor Who has shown the dramatic possibilities of science in the arts.

doi: 10.1038/502594a



Polio risk looms over Europe p.601

Cases in Syria highlight vulnerability of nearby countries to the viral disease.

doi: 10.1038/502601a


Root of maths genius sought p.602

Entrepreneur’s ‘Project Einstein’ taps 400 top academics for their DNA.

doi: 10.1038/502602a


Black holes shrink but endure p.603

Theorist’s idea takes on information-preservation problem.

doi: 10.1038/502603a


Lightning network tested out in Guinea p.604

Project to forecast African storms provides cheap alternative to radar-based weather services.

doi: 10.1038/502604a


Astronomers revisit dwarf stars’ promise p.606

Kepler data spur searches for habitable planets around small, low-temperature stars.

doi: 10.1038/502606a


Farmers dig into soil quality p.607

Analytical technique promises to match fertilizers to soil in bid to boost yields in Africa.

doi: 10.1038/502607a



Astronomy: Southern star p.608

Can the Southern African Large Telescope live up to its potential?

doi: 10.1038/502608a


Ecology: Lady of the lakes p.612

Diane Orihel set her PhD aside to lead a massive protest when Canada tried to shut down its unique Experimental Lakes Area.

doi: 10.1038/502612a

News & Views


Ecology: Drivers of decoupling in drylands p.628


doi: 10.1038/502628a


Structural biology: Pivotal findings for a transcription machine p.629


doi: 10.1038/nature12700


Quantum physics: Single electrons pop out of the Fermi sea p.630


doi: 10.1038/nature12699


Biophysics: Rough passage across a barrier p.632


doi: 10.1038/nature12697


Water management: The data gap p.633


doi: 10.1038/502633a


Marine biology: Coral animals combat stress with sulphur p.634


doi: 10.1038/nature12698



Arteriolar niches maintain haematopoietic stem cell quiescence p.637

Immunofluorescence imaging and computational modelling are used to study the spatial distribution of different cell types within the haematopoietic stem cell (HSC) niche; findings show that quiescent HSCs associate specifically with small arterioles that are preferentially found in the endosteal bone marrow and are essential in maintaining this quiescence.

doi: 10.1038/nature12612


Crystal structure of the 14-subunit RNA polymerase I p.644

RNA polymerase (Pol) I transcribes ribosomal RNA that is critically required for ribosome assembly, and the enzyme is a major determinant of protein biosynthesis and cell growth; here the crystal structure of the complete 14-subunit Pol I from yeast is determined, providing insights into its unique architecture and the possible functional roles of its components.

doi: 10.1038/nature12636


RNA polymerase I structure and transcription regulation p.650

The crystal structure of the complete 14-subunit RNA polymerase (Pol) I from yeast is determined, providing insights into its unique architecture and the possible functional roles of its components.

doi: 10.1038/nature12712



A uniform metal distribution in the intergalactic medium of the Perseus cluster of galaxies p.656

A uniform iron abundance in the intracluster gas of the Perseus cluster suggests that the metal enrichment of the intergalactic medium occurred before the cluster formed, probably more than ten billion years ago, rather than after the cluster formed.

doi: 10.1038/nature12646


Minimal-excitation states for electron quantum optics using levitons p.659

Minimal-excitation fermionic quasiparticles are created by applying a potential with Lorentzian time dependence to the contact of a narrow constriction in a two-dimensional electron gas.

doi: 10.1038/nature12713


Coupling a single electron to a Bose–Einstein condensate p.664

A single electron in a defined orbital is found to interact with a quantum many-body system through electron–phonon coupling.

doi: 10.1038/nature12592


Gradual demise of a thin southern Laurentide ice sheet recorded by Mississippi drainage p.668

Four reconstructions of North American ice-sheet history are tested using oxygen isotope records from the Gulf of Mexico in a water-mixing model; the one based on ice physics is the best match to the isotopic data and to the observed Last Glacial Maximum fall in sea level due to melting of the Laurentide ice sheet.

doi: 10.1038/nature12609


Decoupling of soil nutrient cycles as a function of aridity in global drylands p.672

Soil samples collected from 224 dryland sites around the world show that aridity affects the concentration of organic carbon and total nitrogen differently from the concentration of inorganic phosphorus, suggesting that any predicted increase in aridity with climate change could uncouple the carbon, nitrogen and phosphorus cycles in drylands and negatively affect the services provided by these ecosystems.

doi: 10.1038/nature12670


DMSP biosynthesis by an animal and its role in coral thermal stress response p.677

Until now, dimethylsulphoniopropionate (DMSP), an important component in the sulphur cycle, has been thought to be produced solely by algae and some plants; however, this study shows that the coral animal also produces DMSP, in addition to that produced by the coral’s algal symbiont, with potential implications for the sulphur cycle and its climatic consequences as corals and their symbionts are affected by global change.

doi: 10.1038/nature12677


Structural insight into magnetochrome-mediated magnetite biomineralization p.681

The magnetosome-associated protein mamP is an iron oxidase that reveals a unique arrangement of a self-plugged PDZ domain fused to two magnetochrome domains, defining a new class of c-type cytochrome exclusively found in magnetotactic bacteria.

doi: 10.1038/nature12573


Single-molecule fluorescence probes dynamics of barrier crossing p.685

Here the Kramers diffusion coefficient and free-energy barrier are characterized for the first time through single-molecule fluorescence measurements of the temperature- and viscosity-dependence of the transition path time for protein folding.

doi: 10.1038/nature12649


Photosynthetic entrainment of the Arabidopsis thaliana circadian clock p.689

In Arabidopsis thaliana, the rhythm of sugar production by photosynthesis sets the timing of the circadian clock, by regulating the expression of circadian clock genes.

doi: 10.1038/nature12603


Synthetic non-oxidative glycolysis enables complete carbon conservation p.693

A non-oxidative, cyclic pathway—termed non-oxidative glycolysis—is designed and constructed that enables complete carbon conservation in sugar catabolism to acetyl-coenzyme A, and can be used to achieve a 100% carbon yield to fuels and chemicals.

doi: 10.1038/nature12575


Discovery of new enzymes and metabolic pathways by using structure and genome context p.698

Pathway docking (in silico docking of metabolites to several enzymes and binding proteins in a metabolic pathway) enables the discovery of a catabolic pathway for the osmolyte trans-4-hydroxy-l-proline betaine.

doi: 10.1038/nature12576


Meiotic chromosome structures constrain and respond to designation of crossover sites p.703

Meiotic crossover regulation is proposed to operate as a self-limiting system in which meiotic chromosome structures create an environment that promotes crossovers, which in turn modify chromosome structures to inhibit crossover formation at additional neighbouring sites.

doi: 10.1038/nature12577


Visualizing virus assembly intermediates inside marine cyanobacteria p.707

This study reports the first application of Zernike phase contrast (ZPC) electron cryo-tomography to examine cellular processes without the need for labelling or sectioning; the technique is used to visualize the maturation of the cyanophage Syn5 inside its host cell, identifying subcellular compartments and five distinct Syn5 assembly intermediates.

doi: 10.1038/nature12604

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