Research Abstract


Synthetic cell division system: Controlling equal vs. unequal divisions by design

2013年12月11日 Scientific Reports 3 : 3475 doi: 10.1038/srep03475


佐藤 洋一1, 安原 主馬2, 菊池 純一2 & トーマス・サトウ(佐藤 匠徳)1,3,4,5,6

  1. 奈良先端科学技術大学院大学・バイオサイエンス研究科
  2. 奈良先端科学技術大学院大学・物質創成科学研究科
  3. コーネル大学・生物医工学研究科(米国)
  4. センテナリー研究所(オーストラリア)
  5. 独立行政法人 科学技術振興機構(JST) ERATO 佐藤ライブ予測制御プロジェクト
  6. 国際電気通信基礎技術研究所
Cell division is one of the most fundamental and evolutionarily conserved biological processes. Here, we report a synthetic system where we can control by design equal vs. unequal divisions. We synthesized a micro-scale inverse amphipathic droplet of which division is triggered by the increase of surface to volume ratio. Using this system, we succeeded in selectively inducing equal vs. unequal divisions of the droplet cells by adjusting the temperature or the viscosity of the solvent outside the droplet cell accordingly. Our synthetic division system may provide a platform for further development to a system where intracellular contents of the parent droplet cell could be divided into various ratios between the two daughter droplet cells to control their functions and fates.