Research Abstract


Conserved properties of dendritic trees in four cortical interneuron subtypes

2011年9月13日 Scientific Reports 1 : 89 doi: 10.1038/srep00089


窪田 芳之1,2,3, 苅部 冬紀1,3, 野村 真樹3,4, Allan T. Gulledge5, 望月 敦史6, Andreas Schertel7 & 川口 泰雄1,2,3

  1. 自然科学研究機構 生理学研究所
  2. 国立大学法人 総合研究大学院大学
  3. 独立行政法人 科学技術振興機構 CREST
  4. 独立行政法人 理化学研究所 免疫・アレルギー科学 総合研究センター
  5. ダートマス大学医学系大学院(米国)
  6. 独立行政法人 理化学研究所 基幹研究所
  7. カール ツァイスNTS社(ドイツ)
Dendritic trees influence synaptic integration and neuronal excitability, yet appear to develop in rather arbitrary patterns. Using electron microscopy and serial reconstructions, we analyzed the dendritic trees of four morphologically distinct neocortical interneuron subtypes to reveal two underlying organizational principles common to all. First, cross-sectional areas at any given point within a dendrite were proportional to the summed length of all dendritic segments distal to that point. Consistent with this observation, total cross-sectional area was almost perfectly conserved at bifurcation points. Second, dendritic cross-sections became progressively more elliptical at more proximal, larger diameter, dendritic locations. Finally, computer simulations revealed that these conserved morphological features limit distance dependent filtering of somatic EPSPs and facilitate distribution of somatic depolarization into all dendritic compartments. Because these features were shared by all interneurons studied, they may represent common organizational principles underlying the otherwise diverse morphology of dendritic trees.