Research press release


Nature Physics

Wound closure involves cooperative compression



Xavier Trepartたちは、牽引力、つまり細胞がその周囲に及ぼす力を測定して、細胞が傷ついた場所に向かって移動する際に関与する物理的な力を調べた。その結果、治癒の第二段階では、この生体高分子の環が周囲に収縮力を伝えることが示唆された。この力が、細胞外環境を締めつけて、傷ついた場所に向かって移動細胞を進ませるのである。

The process by which wounds are repaired is more complex than was previously thought, reports a paper published online this week in Nature Physics. These findings motivate new strategies for assisted wound repair and provide insight into our understanding of how the spatial distribution and migration of cells enables tissue development.

Wound repair is initiated by cells that crawl towards the injury site, with later stages of the process relying on the contraction of a cable-like ring of biopolymers. This ring is thought to aid cell migration by drawing in like a purse-string to pull cells together over the damaged site.

Xavier Trepart and colleagues use traction force measurements - measurements of the force a cell exerts on its surroundings - to look at the physical forces involved as cells move towards the injury site. They suggest that in the second phase of healing, the biopolymer ring transmits a contractile force to its surroundings. This force compresses the extracellular environment, and steers the migrating cells towards the injury site.

doi: 10.1038/nphys3040


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