Research press release


Nature Genetics

Genetic insight into anorexia nervosa


神経性無食欲症は、複雑で重篤な疾患で、死亡率は他の精神疾患よりも高い。今回、Cynthia Bulikたちの研究グループは、神経性無食欲症遺伝学イニシアチブ(Anorexia Nervosa Genetics Initiative)と精神疾患ゲノミクスコンソーシアム(Psychiatric Genomics Consortium)の摂食障害ワーキンググループ(Eating Disorders Working Group)が収集したデータを基に、神経性無食欲症の患者(1万6992人)と対照被験者(5万5525人)のゲノム解析を行った。その結果、神経性無食欲症に関連する8種類の遺伝的マーカーが突き止められ、神経性無食欲症の遺伝的構造の解析をより正確に行うことができるようになった。また、神経性無食欲症は、強迫性障害や大うつ病などの精神疾患と相関するだけでなく、身体活動や代謝形質とも遺伝的な相関が見られることが分かった。


Eight significant genetic markers for anorexia nervosa are identified in an analysis of almost 17,000 cases in a paper published this week in Nature Genetics. The study represents the largest known genome-wide association study on anorexia nervosa to date.

Anorexia nervosa is a complex and serious illness with a higher mortality rate than other psychiatric disorders.

Cynthia Bulik and colleagues analysed the genomes of 16,992 anorexia nervosa patients and 55,525 controls from data collected by the Anorexia Nervosa Genetics Initiative and the Eating Disorders Working Group of the Psychiatric Genomics Consortium. The authors identified eight genetic markers associated with anorexia nervosa and were able to perform a more accurate analysis of the genetic architecture of the disorder. They found that anorexia nervosa has genetic correlations with certain psychiatric disorders - such as obsessive compulsive disorder and major depressive disorder - as well as physical activity and metabolic traits.

The authors conclude that these findings provide further evidence that anorexia nervosa is a metabo-psychiatric disease, and that attention to both aspects may guide more effective treatments in the future.

doi: 10.1038/s41588-019-0439-2


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