Research press release


Nature Communications

Obesity: A potential fat-burner


今回、Alexander Pfeiferたちは、肥満マウスの体内における褐色脂肪とベージュ脂肪の生成が、可溶性グアニリルシクラーゼ(sGC)という酵素によって駆動される細胞内シグナル伝達経路によって活性化されることを明らかにした。また、sGC刺激剤を肥満マウスに実験的に注入したところ、脂質の燃焼量が増え、その結果、白色脂肪(貯蔵脂肪)が減少したためにマウスの体重が減った。


A drug that promotes weight loss in obese mice by causing them to burn off excess calories is reported in a study published in Nature Communications this week. The drug causes the mice to generate more brown and beige fat, which are specialised tissues that burn lipid molecules to generate heat.

Alexander Pfeifer and colleagues have now shown that a cellular signalling pathway driven by the enzyme soluble guanylate cyclase (sGC) activates the formation of brown and beige fat in obese mice. After treatment with an experimental drug that stimulates sGC the mice burn off more lipids; this then causes them to become leaner due to a reduction in white (storage) fat.

Although the drug has not been tested in humans, the authors speculate that it may have a favourable safety profile as it is chemically similar and belongs to the same class as the drug riociguat, which has recently been approved for the treatment of pulmonary hypertension. The authors hope that their findings may provide a potential candidate for the treatment of obesity and certain associated illnesses.

doi: 10.1038/ncomms8235

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